Abstract: A method and system include receiving a medical test request for a patient to perform a medical test to measure a biomarker using a rapid diagnostic test (RDT). The patient is instructed to perform the RDT. A first image stream of the RDT, including a test region displaying a visual indicator, is received from a camera coupled to the client device. A computer vision technique of a deep learning module is used to identify device features in the first image stream. A second image stream including the test region is received from the camera and applied to the deep learning module to: identify and classify the device features of the test region. A presence, a level, or both of the biomarker are determined from an RDT result based on the visual indicator in a second image.

Abstract: Disclosed are computer systems and computer-implemented methods for rapid diagnostic test result interpretation platform employing computer vision. The system can visually analyze the test device in real-time by receiving image streams of the test device from the camera system. The detection system can be used to identify the test result in the test region. In some embodiments, the test result is binary (e.g., Positive/Negative). In some embodiments, the test result is in semi-quantitative formats (e.g., 1-10). The test result can be sent back to the user, operator, HMO, or physician for further confirmation, recording, and medical treatment decision/follow-up. The detection system can close the loop between the user of the test device and the HMO/physician for recording of the test result and the provision of medical treatment/follow-up.

Abstract: Disclosed are computer systems and computer-implemented methods for rapid diagnostic test result interpretation platform employing computer vision. The system can visually analyze the test device in real-time by receiving image streams of the test device from the camera system. The detection system can be used to identify the test result in the test region. In some embodiments, the test result is binary (e.g., Positive/Negative). In some embodiments, the test result is in semi-quantitative formats (e.g., 1-10). The test result can be sent back to the user, operator, HMO, or physician for further confirmation, recording, and medical treatment decision/follow-up. The detection system can close the loop between the user of the test device and the HMO/physician for recording of the test result and the provision of medical treatment/follow-up.

Abstract: A wearable sensor patch including a generally cylindrical base having a bore, and a skin contact surface having an adhesive thereon; a piston-like part positioned within the bore; at least one microprobe positioned on the piston-like part; a retention spring; wherein the piston-like part is movable within the bore of the base between (1) a first position in which the at least one microprobe is positioned within the bore, and (2) a second position in which the at least one microprobe protrudes past the skin contact surface, and wherein the retention spring and the piston-like part are configured to cooperate such that the retention spring retains the piston-like part in either the first position or the second position

Abstract: A sensor includes a working electrode in contact with an analyte solution; an amplifier including: a source terminal; a drain terminal; a back gate terminal; and nanowires, each nanowire electrically connecting the source terminal to the drain terminal; and an insulator having a first side and a second side. The working electrode is positioned to the first side of the insulator. The source terminal, the drain terminal, and the nanowires are positioned to the second side of the insulator. The insulator prevents direct electrical contact between the working electrode, the analyte solution and either the source terminal, the drain terminal, or the nanowires. The working electrode is configured such that, when a chemical species is present in the analyte solution, a variation in an electrical field at a location of the nanowires is induced, inducing a corresponding variation in an electrical current between the source terminal and the drain terminal.

Abstract: In some embodiments, the present invention is a device, including: a swab including an absorptive component attached to a stem, an extraction chamber configured to receive the swab and position the absorptive component of the swab configured to be in fluid communication with an extraction reagent, a test strip configured to be brought in fluid communication with the extraction reagent following extraction of the analyte from the biological sample, including: a sample receiving portion configured to accept a sample, a site on the strip where the analyte-specific labeled reagent has been incorporated, such reagent configured to bind the analyte from the biological sample, a capture portion configured to receive: the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and an adsorbent pad attached to the test strip.

Abstract: In some embodiments, the present invention is a device, including: a swab including an absorptive component attached to a stem, an extraction chamber configured to receive the swab and position the absorptive component of the swab configured to be in fluid communication with an extraction reagent, a test strip configured to be brought in fluid communication with the extraction reagent following extraction of the analyte from the biological sample, including: a sample receiving portion configured to accept a sample, a site on the strip where the analyte-specific labeled reagent has been incorporated, such reagent configured to bind the analyte from the biological sample, a capture portion configured to receive: the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and an adsorbent pad attached to the test strip.

Abstract: Disclosed are computer systems and computer-implemented methods for rapid diagnostic test result interpretation platform employing computer vision. The system can visually analyze the test device in real-time by receiving image streams of the test device from the camera system. The detection system can be used to identify the test result in the test region. In some embodiments, the test result is binary (e.g., Positive/Negative). In some embodiments, the test result is in semi-quantitative formats (e.g., 1-10). The test result can be sent back to the user, operator, HMO, or physician for further confirmation, recording, and medical treatment decision/follow-up. The detection system can close the loop between the user of the test device and the HMO/physician for recording of the test result and the provision of medical treatment/follow-up.

Abstract: A sensing system includes a microprobe, the microprobe including: a layered structure including: a sensing unit comprising a sensor including a working electrode, wherein the sensing unit has a first perimeter when viewed along a layering direction, includes a first material having a first toughness, and including a first side and a second side; a deformable layer configured to deform under stress and positioned on the first side of the sensing unit; a ductile layer positioned on the deformable layer opposite the sensing unit and having a second perimeter when viewed along the layering direction, the first perimeter being within the second perimeter, the ductile layer including a second material having a second toughness greater than the first toughness; a sensor-interface layer positioned on the second side of the sensing unit; and an encapsulant partially encapsulating the layered structure and mechanically isolating the layered structure from a surrounding environment.

Abstract: A sensor includes a working electrode in contact with an analyte solution; an amplifier including: a source terminal; a drain terminal; a back gate terminal; and nanowires, each nanowire electrically connecting the source terminal to the drain terminal; and an insulator having a first side and a second side. The working electrode is positioned to the first side of the insulator. The source terminal, the drain terminal, and the nanowires are positioned to the second side of the insulator. The insulator prevents direct electrical contact between the working electrode, the analyte solution and either the source terminal, the drain terminal, or the nanowires. The working electrode is configured such that, when a chemical species is present in the analyte solution, a variation in an electrical field at a location of the nanowires is induced, inducing a corresponding variation in an electrical current between the source terminal and the drain terminal.

Abstract: A sensor includes a working electrode in contact with an analyte solution; an amplifier including: a source terminal; a drain terminal; a back gate terminal; and nanowires, each nanowire electrically connecting the source terminal to the drain terminal; and an insulator having a first side and a second side. The working electrode is positioned to the first side of the insulator. The source terminal, the drain terminal, and the nanowires are positioned to the second side of the insulator. The insulator prevents direct electrical contact between the working electrode, the analyte solution and either the source terminal, the drain terminal, or the nanowires. The working electrode is configured such that, when a chemical species is present in the analyte solution, a variation in an electrical field at a location of the nanowires is induced, inducing a corresponding variation in an electrical current between the source terminal and the drain terminal.

Abstract: A device including a casing first part; a casing second part; a test strip having a sample pad; and a capillary sample collector, wherein the capillary sample collector has an open distal end configured to collect a fluid sample by capillary action and an open proximal end configured to dispense the fluid sample therefrom, wherein, the device is assembled such that the casing first part and the casing second part are joined, wherein a distal end of the casing first part and a distal end of the casing second part are sealed together in a fluid-tight manner, wherein the sample pad is positioned in proximity to the capillary dispensing end, wherein the dispensing end is positioned such that a dispensed fluid sample will be dispensed onto the sample pad, and wherein a dispensing angle between the dispensing and the sample pad of the test strip is less than 10 degrees.

Abstract: In some embodiments, the present invention is a device, including: a swab including an absorptive component attached to a stem, an extraction chamber configured to receive the swab and position the absorptive component of the swab configured to be in fluid communication with an extraction reagent, a test strip configured to be brought in fluid communication with the extraction reagent following extraction of the analyte from the biological sample, including: a sample receiving portion configured to accept a sample, a site on the strip where the analyte-specific labeled reagent has been incorporated, such reagent configured to bind the analyte from the biological sample, a capture portion configured to receive: the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and an adsorbent pad attached to the test strip.

Abstract: In some embodiments, the present invention is a device, including: a swab including an absorptive component attached to a stem, an extraction chamber configured to receive the swab and position the absorptive component of the swab configured to be in fluid communication with an extraction reagent, a test strip configured to be brought in fluid communication with the extraction reagent following extraction of the analyte from the biological sample, including: a sample receiving portion configured to accept a sample, a site on the strip where the analyte-specific labeled reagent has been incorporated, such reagent configured to bind the analyte from the biological sample, a capture portion configured to receive: the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and an adsorbent pad attached to the test strip.

Abstract: In some embodiments, the present invention is a device, including: a swab including an absorptive component attached to a stem, an extraction chamber configured to receive the swab and position the absorptive component of the swab configured to be in fluid communication with an extraction reagent, a test strip configured to be brought in fluid communication with the extraction reagent following extraction of the analyte from the biological sample, including: a sample receiving portion configured to accept a sample, a site on the strip where the analyte-specific labeled reagent has been incorporated, such reagent configured to bind the analyte from the biological sample, a capture portion configured to receive: the analyte from the biological sample and the analyte-specific labeled reagent so as to result in displaying a positive or negative result at the completion of the assay, and an adsorbent pad attached to the test strip.

Abstract: A biological sample device for detecting the presence or absence of specific analytes in a sample is provided. A sample, such as a blood or urine sample or a pre-processed tissue sample is collected on a porous pad. A first membrane in liquid communication with the sample pad includes an analyte-specific, electroactively-labeled detection reagent reactive with the an analyte. A second membrane in liquid communication with the first membrane includes a biosensor whose surface has been modified by an analyte-specific capture reagent. The analyte-binding capture reagent immobilizes the analyte electroactive label complex on the surface of the biosensor, whereby direct interaction of the electroactive label with the surface of the biosensor generates an electric signal used by an electronic processing unit to determine whether the analyte is present in the sample.

Abstract: A sieving device and related methods including an expandable sieve mounted on a surgical guide wire. The expandable sieve may be a self-expandable braided filter which is mounted on the guide wire in an axially fixed position, or moveable in one or more directions. The sieving device is deployable in an obstructed ureter, or other body lumen, such as at the beginning of a stone removal procedure, prior to actual stone defragmentation (lithotripsy) phase. The expandable sieve may be set distal to the obstructive stone and expanded to span the entire local ureter cross section in order to retain stone fragments larger than a predetermined size from migrating distally towards the kidney under high irrigation rates/pressures during lithotripsy.