Patents by Inventor Ie-Ming Shih

Ie-Ming Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule compounds targeting PBX1 transcriptional complex
    Patent number: 10800742
    Abstract: In accordance with one or more embodiments, the present invention provides a compound of formulas I, II, and III, for use in methods of inhibition of PBX1-DNA interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 13, 2020
    Assignee: The Johns Hopkins University
    Inventors: Tian-Li Wang, Ie-Ming Shih, Mark Vaal, Alexander Stoeck, Jin G. Jung
  • SMALL MOLECULE COMPOUNDS TARGETING PBX1 TRANSCRIPTIONAL COMPLEX
    Publication number: 20180118688
    Abstract: In accordance with one or more embodiments, the present invention provides a compound of formulas I, II, and III, for use in methods of inhibition of PBX1-DNA interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.
    Type: Application
    Filed: April 22, 2016
    Publication date: May 3, 2018
    Inventors: Tian-Li Wang, Ie-Ming Shih, Mark Vaal, Alexander Stoeck, Jin G. Jung
  • DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy
    Patent number: 8835110
    Abstract: The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: September 16, 2014
    Assignee: The Johns Hopkins University
    Inventors: Tza-Huei Wang, Kelvin J. Liu, Ie-Ming Shih
  • DNA INTEGRITY ASSAY (DIA) FOR CANCER DIAGNOSTICS, USING CONFOCAL FLUORESCENCE SPECTROSCOPY
    Publication number: 20110171741
    Abstract: The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer.
    Type: Application
    Filed: November 4, 2009
    Publication date: July 14, 2011
    Applicant: The Johns Hopkins University
    Inventors: Tza-Huei Wang, Kelvin J. Liu, Ie-Ming Shih
  • RSF-1 as a prognostic marker and therapeutic target
    Publication number: 20070280969
    Abstract: The instant invention provides cancer markers and methods of prognosis and diagnosis based on detection and/or quantitation of these markers. The invention further provides compositions for the treatment of cancer.
    Type: Application
    Filed: November 24, 2006
    Publication date: December 6, 2007
    Applicant: The Johns Hopkins University
    Inventors: Ie-Ming Shih, Tian-Li Wang