Patents by Inventor Igor Nikonorov
Igor Nikonorov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230191409Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for the multiplexed analysis of biological material. In some embodiments, the apparatus may comprise an assembly including a first frame including a plurality of first openings; a capture agent slide; and a channel membrane.Type: ApplicationFiled: February 26, 2021Publication date: June 22, 2023Inventors: Benjamin PORTS, Igor NIKONOROV, Peter TSIOMPLIKAS, Michael KANE, Sergei IVANI, Patrick PACZKOWSKI, Luka DJAPIC
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Patent number: 11583851Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: GrantFiled: August 26, 2019Date of Patent: February 21, 2023Assignee: Abbott Point of Care Inc.Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Publication number: 20230052346Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles. In some embodiments, the apparatus may be configured to analyze substances expressed by a biological cell and may include a first compressible substrate, and a second substrate configured for removable sealing attachment with the first substrate. In some embodiments, upon attachment of the second substrate with the first substrate, an assembly is formed such that the open side of the plurality of chambers are covered by the second substrate, and a portion of each of the plurality of capture areas are exposed in each of the chambers.Type: ApplicationFiled: October 26, 2022Publication date: February 16, 2023Inventors: Peter TSIOMPLIKAS, Jerry SEDGEWICK, Jeffrey WHYNALL, Sean MACKAY, Colin NG, Patrick PACZKOWSKI, Sean MCCUSKER, Igor NIKONOROV, Alaina KAISER
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Patent number: 11525783Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles. In some embodiments, the apparatus may be configured to analyze substances expressed by a biological cell and may include a first compressible substrate, and a second substrate configured for removable sealing attachment with the first substrate. In some embodiments, upon attachment of the second substrate with the first substrate, an assembly is formed such that the open side of the plurality of chambers are covered by the second substrate, and a portion of each of the plurality of capture areas are exposed in each of the chambers.Type: GrantFiled: November 22, 2017Date of Patent: December 13, 2022Assignee: IsoPlexis CorporationInventors: Peter Tsiomplikas, Jerry Sedgewick, Jeffrey Whynall, Sean MacKay, Colin Ng, Patrick Paczkowski, Sean McCusker, Igor Nikonorov, Alaina Kaiser
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Publication number: 20190376898Abstract: Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles. In some embodiments, the apparatus may be configured to analyze substances expressed by a biological cell and may include a first compressible substrate, and a second substrate configured for removable sealing attachment with the first substrate. In some embodiments, upon attachment of the second substrate with the first substrate, an assembly is formed such that the open side of the plurality of chambers are covered by the second substrate, and a portion of each of the plurality of capture areas are exposed in each of the chambers.Type: ApplicationFiled: November 22, 2017Publication date: December 12, 2019Applicant: IsoPlexis CorporationInventors: Peter TSIOMPLIKAS, Jerry SEDGEWICK, Jeffrey WHYNALL, Sean MACKAY, Colin NG, Patrick PACZKOWSKI, Sean MCCUSKER, Igor NIKONOROV, Alaina KAISER
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Publication number: 20190374943Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: ApplicationFiled: August 26, 2019Publication date: December 12, 2019Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Patent number: 10391487Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: GrantFiled: January 22, 2018Date of Patent: August 27, 2019Assignee: Abbott Point of Care, Inc.Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Publication number: 20180141045Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: ApplicationFiled: January 22, 2018Publication date: May 24, 2018Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Patent number: 9873118Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: GrantFiled: December 30, 2011Date of Patent: January 23, 2018Assignee: Abbott Point of Care, Inc.Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Patent number: 9199236Abstract: A biological fluid sample analysis cartridge is provided that includes a collection port and a body. The body has one or more internal channels in selective fluid communication with the collection port. The collection port includes a collection bowl, and a slide valve assembly operable to be selectively positioned in an open position and a closed position. In the open position, the collection bowl is accessible for sample deposition, and in the closed position the collection bowl is inaccessible for sample deposition.Type: GrantFiled: December 31, 2012Date of Patent: December 1, 2015Assignee: Abbott Point of Care, Inc.Inventors: Igor Nikonorov, John Blum, Douglas R. Olson, Marek Turewicz
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Patent number: 8797527Abstract: A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.Type: GrantFiled: August 24, 2012Date of Patent: August 5, 2014Assignee: Abbott Point of Care, Inc.Inventors: Kyle Hukari, Igor Nikonorov, Ralph W. Dowdell, Douglas Olson, Niten V. Lalpuria, Darryn Unfricht, Benjamin Ports, Vu Phan, Robin A. Levy, John W. Roche
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Patent number: 8753890Abstract: An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.Type: GrantFiled: December 8, 2011Date of Patent: June 17, 2014Assignee: Abbott Point of Care, Inc.Inventors: Niten V. Lalpuria, Darryn W. Unfricht, Igor Nikonorov, Benjamin Ports, Douglas R. Olson
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Publication number: 20130114075Abstract: A biological fluid sample analysis cartridge, analysis system, and method for analyzing a biologic fluid sample are provided. The cartridge includes a collection port, at least one channel within the cartridge in fluid communication with the collection port, a passage in fluid communication with the at least one channel, and an analysis chamber mounted on a tray. The tray is mounted relative to the cartridge and selectively positionable relative to the passage in a first position where the analysis chamber will engage a bolus of sample extending out from the passage to permit selective transfer of sample from the bolus to the analysis chamber.Type: ApplicationFiled: August 24, 2012Publication date: May 9, 2013Applicant: Abbott Point of Care, Inc.Inventors: Kyle Hukari, Igor Nikonorov, Ralph W. Dowdell, Douglas Olson, Niten V. Lalpuria, Darryn Unfricht, Benjamin Ports, Vu Phan, Robin A. Levy, John W. Roche
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Publication number: 20120219457Abstract: A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.Type: ApplicationFiled: December 30, 2011Publication date: August 30, 2012Applicant: Abbott Point of Care, Inc.Inventors: John A. Verrant, Niten V. Lalpuria, Igor Nikonorov, Darryn W. Unfricht, Benjamin Ports, Stephen C. Wardlaw, Robert A. Levine, Robert Holt, Kyle Hukari
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Publication number: 20120149118Abstract: An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.Type: ApplicationFiled: December 8, 2011Publication date: June 14, 2012Applicant: ABBOTT POINT OF CARE, INC.Inventors: Niten V. Lalpuria, Darryn W. Unfricht, Igor Nikonorov, Benjamin Ports, Douglas R. Olson
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Publication number: 20110244581Abstract: An apparatus for and method of analyzing a biologic fluid sample is provided. The method includes the steps of: a) providing a sample cartridge having at least one channel for fluid sample passage; b) providing an analysis device having imaging hardware, a programmable analyzer, and a sample motion system, which sample motion system includes a bidirectional fluid actuator operable to selectively move a bolus of sample axially within the channel, and to cycle the bolus back and forth within the channel; and c) cycling the bolus of sample disposed within the channel at a predetermined frequency until constituents within the sample are substantially uniformly distributed, using the bidirectional fluid actuator.Type: ApplicationFiled: March 31, 2011Publication date: October 6, 2011Applicant: Abbott Point of Care, Inc.Inventors: Igor Nikonorov, Niten V. Lalpuria, Jeremy Hill, John Wieners, Anil S. Patil, Robert Levine, Benjamin Ports, Darryn Unfricht
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Patent number: 7261566Abstract: Described is a method and system for training medical professionals to perform a nerve block procedure. The system may include a nerve electrode at least partially inserted in a conductive gel and an NSMRD supplying a current signal to a needle which is inserted in the gel. The system may also include a processing arrangement which is connected to the NSMRD. The processing arrangement receives a transmitted current from the nerve electrode via the needle and measures a voltage drop. The measured voltage drop increases as a distance between the needle and the nerve electrode decreases.Type: GrantFiled: April 28, 2003Date of Patent: August 28, 2007Assignee: New York UniversityInventors: Thomas J. J. Blanck, Igor Nikonorov
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Publication number: 20040214149Abstract: Described is a method and system for training medical professionals to perform a nerve block procedure. The system may include a nerve electrode at least partially inserted in a conductive gel and an NSMRD supplying a current signal to a needle which is inserted in the gel. The system may also include a processing arrangement which is connected to the NSMRD. The processing arrangement receives a transmitted current from the nerve electrode via the needle and measures a voltage drop. The measured voltage drop increases as a distance between the needle and the nerve electrode decreases.Type: ApplicationFiled: April 28, 2003Publication date: October 28, 2004Inventors: Thomas J.J. Blanck, Igor Nikonorov