Patents by Inventor Igor Quinones-Garcia
Igor Quinones-Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884945Abstract: The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological materials, such as, ASA-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration.Type: GrantFiled: July 1, 2022Date of Patent: January 30, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Dave Nichols, Igor Quinones-Garcia, Bee Lin Cheang, Mei Huei Jang
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Publication number: 20230414698Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.Type: ApplicationFiled: February 15, 2023Publication date: December 28, 2023Inventors: Igor QUINONES-GARCIA, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
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Publication number: 20230235303Abstract: The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological materials, such as, ASA-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration.Type: ApplicationFiled: July 1, 2022Publication date: July 27, 2023Inventors: Dave Nichols, Igor Quinones-Garcia, Bee Lin Cheang, Mei Huei Jang
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Patent number: 11407984Abstract: The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological materials, such as, ASA-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration.Type: GrantFiled: January 9, 2014Date of Patent: August 9, 2022Assignee: Takeda Pharmaceutical Company LimitedInventors: Dave Nichols, Igor Quinones-Garcia, Mei Huei Jang, Bee Lin Cheang
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Publication number: 20200316158Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.Type: ApplicationFiled: May 15, 2020Publication date: October 8, 2020Inventors: Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
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Patent number: 10695395Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.Type: GrantFiled: December 21, 2016Date of Patent: June 30, 2020Assignee: PHOENIX TISSUE REPAIR, INC.Inventors: Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
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Patent number: 10669327Abstract: The present disclosure provides methods for capturing recombinant collagen 7 from cell culture and methods of purifying recombinant collagen 7. Also provided are compositions comprising purified recombinant collagen 7 that may be used for administration to humans.Type: GrantFiled: March 10, 2017Date of Patent: June 2, 2020Assignee: PHOENIX TISSUE REPAIR, INC.Inventors: Igor Quinones-Garcia, Benjamin Simeone, Raymond Lillie, Ting Yang, David Nichols
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Publication number: 20190077845Abstract: The present disclosure provides methods for capturing recombinant collagen 7 from cell culture and methods of purifying recombinant collagen 7. Also provided are compositions comprising purified recombinant collagen 7 that may be used for administration to humans.Type: ApplicationFiled: March 10, 2017Publication date: March 14, 2019Inventors: Igor Quinones-Garcia, Benjamin Simeone, Raymond Lillie, Ting Yang, David Nichols
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Publication number: 20190000912Abstract: The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.Type: ApplicationFiled: December 21, 2016Publication date: January 3, 2019Inventors: Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
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Patent number: 9295928Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: November 2, 2010Date of Patent: March 29, 2016Assignee: EMD Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20150353904Abstract: The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological materials, such as, ASA-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration.Type: ApplicationFiled: January 9, 2014Publication date: December 10, 2015Inventors: Dave Nichols, Igor Quinones-Garcia, Bee Lin Cheang, Mei Huei Jang
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Publication number: 20150060342Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: November 7, 2014Publication date: March 5, 2015Inventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20120282654Abstract: The present invention provides, in part, a multi-step process for purifying antibodies including chromatographic purification and filter purification.Type: ApplicationFiled: April 29, 2010Publication date: November 8, 2012Inventors: Yan Yao, Igor Quinones-Garcia, Patricia Rowicki, John Richard Gavin, Collette Marie Cutler, Steven J. Blaisdell
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Publication number: 20110049042Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: November 2, 2010Publication date: March 3, 2011Applicant: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 7824548Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: June 21, 2007Date of Patent: November 2, 2010Assignee: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 7479223Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be crosslinked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: February 3, 2005Date of Patent: January 20, 2009Assignee: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 7479222Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: February 3, 2005Date of Patent: January 20, 2009Assignee: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20070256970Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: June 21, 2007Publication date: November 8, 2007Applicant: Millipore CorporationInventors: Anthony DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20050211615Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: February 3, 2005Publication date: September 29, 2005Applicant: Millipore CorporationInventors: Anthony DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20050211616Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be crosslinked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: February 3, 2005Publication date: September 29, 2005Applicant: Millipore CorporationInventors: Anthony DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil Soice, Volkmar Thom, Sarah Yuan