Publication number: 20050085522
Abstract: A compound of formula I or of tautomeric formula II wherein: R1 and R5 are each independently H, F, Cl, Br, CH2F, CHF2, CF3, Me, or OMe; R2 and R4 are each independently H, a branched C3-6-alkyl, F, Cl, Br, CH2F, CHF2, CF3 or Me, wherein at least one of the groups R2 or R4 is a branched C3-6-alkyl; and R3 is H, F, Cl, Br, CH2F, CHF2, CF3 or Me, or a pharmacologically acceptable salt thereof, pharmaceutical compositions containing these compounds, and their use in treating urinary incontinence or a bladder disease.
Type:
Application
Filed:
December 7, 2004
Publication date:
April 21, 2005
Applicant:
Boehringer Ingelheim International GmbH
Inventors:
Pascale Pouzet, Franz Esser, Matthias Hoffmann, Hisato Kitagawa, Kenji Sakai, Ikunobu Muramatsu
Patent number: 6747051
Abstract: A compound of Formula I or of Formula II
wherein:
R1 is F, Cl, Br, CH2F, CF2H, or CF3;
R2 is NR6R7, where R6 is Me, Et, Pr, or iPr, and R7 is Me, Et or Pr; and
R3, R4, and R5 independently of one another each are H, Me, F, Cl, Br, CH2F, CF2H, or CF3,
and if R4 is Me, F, Cl, Br, CH2F, CF2H, or CF3, then R1 is additionally H or Me, or a pharmacologically acceptable salt thereof. In addition, pharmaceutical compositions comprising an effective amount of these compounds, methods for the treatment or prophylaxis of urinary incontinence and diseases of the bladder using these compounds, and methods for making these compounds are disclosed.
Type:
Grant
Filed:
January 23, 2003
Date of Patent:
June 8, 2004
Assignee:
Boehringer Ingelheim Pharma GmbH & Co. KG
Inventors:
Franz Esser, Pascale Pouzet, Hisato Kitagawa, Kenji Sakai, Ikunobu Muramatsu
Patent number: 6602897
Abstract: A compound of formula I or of formula II
wherein:
R1 is F, Cl, Br, CH2F, CF2H, or CF3;
R2 is NR6R7, where R6 is Me, Et, Pr, or iPr, and R7 is Me, Et or Pr; and
R3, R4, and R5 independently of one another each are H, Me, F, Cl, Br, CH2F, CF2H, or CF3,
and if R4 is Me, F, Cl, Br, CH2F, CF2H, or CF3, then R1 is additionally H or Me,
or a pharmacologically acceptable salt thereof. In addition, pharmaceutical compositions comprising an effective amount of these compounds, methods for the treatment or prophylaxis of urinary incontinence and diseases of the bladder using these compounds, and methods for making these compounds are disclosed.
Type:
Grant
Filed:
October 12, 2001
Date of Patent:
August 5, 2003
Assignee:
Boehringer Ingelheim Pharma KG
Inventors:
Franz Esser, Pascale Pouzet, Hisato Kitagawa, Kenji Sakai, Ikunobu Muramatsu
