Patents by Inventor Ilaria Motto
Ilaria Motto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11833153Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: GrantFiled: September 29, 2022Date of Patent: December 5, 2023Assignee: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Publication number: 20230107393Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: September 29, 2022Publication date: April 6, 2023Applicant: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Patent number: 11491158Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: GrantFiled: January 4, 2021Date of Patent: November 8, 2022Assignee: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Publication number: 20210206759Abstract: The present invention relates to certain substituted heterocondensed pyridone analogues of formula (I) which modulate the activity of Isocitrate Dehydrogenase (IDH). The compounds of this invention are therefore useful in treating diseases caused by mutated IDH1 and/or mutated IDH2 enzyme and/or IDH1 wild type enzyme, in particular cancer, cell proliferative disorders and immune-related disorders. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: May 16, 2019Publication date: July 8, 2021Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Elena CASALE, Francesco CASUSCELLI, Teresa DISINGRINI, Paola MAGNAGHI, Beatrice MALGESINI, Ilaria MOTTO, Stefano NUVOLONI
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Publication number: 20210128563Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: January 4, 2021Publication date: May 6, 2021Applicant: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Patent number: 10918642Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: GrantFiled: December 19, 2019Date of Patent: February 16, 2021Assignee: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Publication number: 20200121686Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: December 19, 2019Publication date: April 23, 2020Applicant: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Patent number: 10561660Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: GrantFiled: June 19, 2017Date of Patent: February 18, 2020Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Publication number: 20190201406Abstract: The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: June 19, 2017Publication date: July 4, 2019Applicant: Nerviano Medical Sciences S.R.L.Inventors: Simona Bindi, Davide Carenzi, Ilaria Motto, Maurizio Pulici
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Patent number: 10221181Abstract: 6-Amino-7-bicyclo-7-deaza-purine derivatives of formula (I): modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.Type: GrantFiled: November 12, 2015Date of Patent: March 5, 2019Assignee: NERVIANO MEDICAL SCIENCES S.r.l.Inventors: Laura Buffa, Maria Menichincheri, Ilaria Motto, Francesca Quartieri
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Publication number: 20170327506Abstract: The present invention relates to 6-amino-7-bicyclo-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.Type: ApplicationFiled: November 12, 2015Publication date: November 16, 2017Applicant: NERVIANO MEICAL SCIENCES S.r.l.Inventors: Laura BUFFA, Maria MENICHINCHERI, Ilaria MOTTO, Francesca QUARTIERI
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Patent number: 9682083Abstract: The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.Type: GrantFiled: May 7, 2014Date of Patent: June 20, 2017Assignee: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Mauro Angiolini, Laura Buffa, Maria Menichincheri, Ilaria Motto, Paolo Polucci, Gabriella Traquandi, Fabio Zuccotto
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Publication number: 20160166575Abstract: The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.Type: ApplicationFiled: May 7, 2014Publication date: June 16, 2016Inventors: Mauro Angiolini, Laura Buffa, Maria Menichincheri, Ilaria Motto, Paolo Polucci, Gabriella Traquandi, Fabio Zuccotto
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Patent number: 8912200Abstract: The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.Type: GrantFiled: July 18, 2012Date of Patent: December 16, 2014Assignee: Nerviano Medical Sciences S.R.L.Inventors: Maria Gabriella Brasca, Jay Aaron Bertrand, Paola Gnocchi, Ilaria Motto, Marcella Nesi, Achille Panzeri, Paola Vianello
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Publication number: 20140194406Abstract: The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.Type: ApplicationFiled: July 18, 2012Publication date: July 10, 2014Applicant: NERVIANO MEDICAL SCIENCES S.R.L.Inventors: Maria Gabriella Brasca, Jay Aaron Bertrand, Paola Gnocchi, Ilaria Motto, Marcella Nesi, Achille Panzeri, Paola Vianello
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Patent number: 8609685Abstract: The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.Type: GrantFiled: November 5, 2008Date of Patent: December 17, 2013Assignee: CISI SCRLInventors: Carlo Scolastico, Leonardo Pierpaolo Manzoni, Pierfausto Seneci, Laura Belvisi, Domenico Delia, Martino Bolognesi, Eloise Mastrangelo, Mario De Mayo De Mari Milani, Ilaria Motto, Carmelo Drago
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Publication number: 20100267692Abstract: The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.Type: ApplicationFiled: November 5, 2008Publication date: October 21, 2010Inventors: Carlo Scolastico, Leonardo Pierpaolo Manzoni, Pierfausto Seneci, Laura Belvisi, Domenico Delia, Martino Bolognesi, Eloise Mastrangelo, Mario Milani, Ilaria Motto, Carmelo Drago