Patents by Inventor Ilmars Stonans

Ilmars Stonans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease
    Patent number: 10351534
    Abstract: Salts of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium, method of preparation thereof and use in the treatment of cardiovascular disease.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: July 16, 2019
    Assignee: JSC GRINDEKS
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Reinis Vilskersts, Solveiga Grinberga
  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures
    Patent number: 10105348
    Abstract: Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 23, 2018
    Assignee: Latvian Institute of Organic Synthesis
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the Treatment of Seizures
    Publication number: 20180200227
    Abstract: Use of 2-(55-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.
    Type: Application
    Filed: August 2, 2016
    Publication date: July 19, 2018
    Inventors: Liga Zvejniece, Maija Dambrova, Baiba Svalbe, Edijs Vavers, Ivars Kalvins, Grigorijs Veinbergs, Ilmars Stonans, Ilga Misane, Maksims Vorona, Aleksandrs Cernobrovijs
  • 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease
    Patent number: 8940793
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 27, 2015
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktors Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease
    Publication number: 20140107202
    Abstract: 4-[(Haloalkyl)(dimethyl)ammonio]butanoates of formula wherein Hal is Cl or F, n=1 or 2, method for preparing thereof and use thereof for treating cardiovascular disease.
    Type: Application
    Filed: April 27, 2012
    Publication date: April 17, 2014
    Applicant: JSC GRINDEKS
    Inventors: Ivars Kalvins, Edgars Liepins, Einars Loza, Maija Dambrova, Ilmars Stonans, Daina Lola, Janis Kuka, Osvalds Pugovics, Viktos Andrianovs, Marina Makrecka, Daina Gustina, Solveiga Grinberga
  • Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer
    Patent number: 8492413
    Abstract: New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium carboxylate-methyl ester, having synergistic cytotoxic effect combined with 5-fluorouracil.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: July 23, 2013
    Assignee: JSC Grindeks
    Inventors: Gunars Duburs, Egils Bisenieks, Irina Sestakova, Ivars Kalvinsh, Brigita Vigante, Janis Uldrikis, Ilona Domraceva, Elina Jascenko, Janis Poikans, Imanta Bruvere, Ilmars Stonans
  • DERIVATIVES OF 1,4-DIHYDROPYRIDINE POSSESSING ANTIVIRAL EFFICACY
    Publication number: 20130131126
    Abstract: 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type compounds having general formula I wherein R is hydrogen or carboxylate-methyl ester, R1 is sodium carboxylate-methyl ester R2 is methyl, ethyl or sodium carboxyate-methyl ester possessing antiviral efficacy.
    Type: Application
    Filed: July 15, 2011
    Publication date: May 23, 2013
    Applicant: JSC Grindeks
    Inventors: Ilmars Stonans, Ilze Jansone, Indra Jonane-Osa, Egils Bisenieks, Gunars Duburs, Ivars Kalvins, Brigita Vigante, Janis Uldrikis, Imanta Bruvere, Liga Zuka, Janis Poikans, Zaiga Neidere
  • PHARMACEUTICAL COMBINATION OF 5-FLUOROURACIL AND DERIVATE OF 1,4-DIHYDROPYRIDINE AND ITS USE IN THE TREATMENT OF CANCER
    Publication number: 20120022088
    Abstract: New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium carboxylate-methyl ester, having synergistic cytotoxic effect combined with 5-fluorouracil.
    Type: Application
    Filed: March 11, 2010
    Publication date: January 26, 2012
    Applicant: JSC GRINDEKS
    Inventors: Gunars Duburs, Egils Bisenieks, Irina Sestakova, Ivars Kalvinsh, Brigita Vigante, Janis Uldrikis, Ilona Domraceva, Elina Jascenko, Janis Poikans, Imanta Bruvere, Ilmars Stonans
  • MEDICAL USE OF 3-2,2,2-TRIMETHYLHYDRAZINIUM PROPIONATE SALTS.
    Publication number: 20110028438
    Abstract: The present invention relates to highly effective treatment of ischemic heart disease with 3-(2,2,2-trimethylhydrazinium) propionate hydrogen fumarate, and 3-(2,2,2-trimethylhydrazinium) propionate dihydrogen phosphate.
    Type: Application
    Filed: December 3, 2008
    Publication date: February 3, 2011
    Inventors: Ivars Kalvinsh, Ilmars Stonans
  • MEDICALL USE OF 3-(2,2,2,-TRIMETHYLYHDRAZINIUM) PROPIONATE HDROGEN FUMARATE AND DIHYDROGEN PHOSEPHATE
    Publication number: 20100234459
    Abstract: Novel medical use of 3-(2,2,2-trimethylhydrazinium) propionate salts for the manufacture of a medicament for prevention and therapy of atherosclerosis.
    Type: Application
    Filed: December 3, 2008
    Publication date: September 16, 2010
    Applicant: JSC GRINDEKS
    Inventors: Ilmars Stonans, Eduard Tararak, Elena Andreyeva