Patents by Inventor Iman FARES

Iman FARES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selection of human hematopoetic stem cells using EPCR
    Patent number: 11725187
    Abstract: It is provided a method of expanding ex vivo hematopoietic stem cells (HSC), the method comprising selecting a population of Endothelial Protein C Receptor (EPCR)+ HSC, culturing the selected HSC thereby expanding said EPCR+ HSC and the use of the expanded EPCR+ HSC for stem cells transplantation.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: August 15, 2023
    Assignee: UNIVERSITE DE MONTREAL
    Inventors: Guy Sauvageau, Iman Fares, Jalila Chagraoui
  • Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells
    Patent number: 10336747
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: July 2, 2019
    Assignee: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy Sauvageau, Yves Gareau, Rejean Ruel, Stephane Gingras, Iman Fares
  • Compounds and methods for enhancing viral gene transfer to human hematopoietic cells
    Patent number: 10273503
    Abstract: Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: April 30, 2019
    Assignees: UNIVERSITE DE MONTREAL, BRITISH COLUMBIA CANCER AGENCY BRANCH, FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Guy Sauvageau, Keith Richard Humphries, Hans-Peter Kiem, Iman Fares, Jalila Chagraoui
  • SELECTION OF HUMAN HEMATOPOETIC STEM CELLS USING EPCR
    Publication number: 20190085291
    Abstract: It is provided a method of expanding ex vivo hematopoietic stem cells (HSC), the method comprising selecting a population of Endothelial Protein C Receptor (EPCR)+ HSC, culturing the selected HSC thereby expanding said EPCR+ HSC and the use of the expanded EPCR+ HSC for stem cells transplantation.
    Type: Application
    Filed: May 31, 2017
    Publication date: March 21, 2019
    Applicants: UNIVERSITE DE MONTREAL, UNIVERSITE DE MONTREAL
    Inventors: Guy SAUVAGEAU, Iman FARES, Jalila CHAGRAOUI
  • COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS
    Publication number: 20180201953
    Abstract: Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.
    Type: Application
    Filed: September 17, 2015
    Publication date: July 19, 2018
    Applicants: UNIVERSITÉ DE MONTRÉAL, BC CANCER AGENCY, FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Guy SAUVAGEAU, Keith HUMPHRIES, Hans-Peter KIEM, Iman FARES, Jalila CHAGRAOUI
  • PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS
    Publication number: 20170334904
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Application
    Filed: December 2, 2016
    Publication date: November 23, 2017
    Applicant: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy SAUVAGEAU, Yves GAREAU, Rejean RUEL, Stephane GINGRAS, Iman FARES
  • Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells
    Patent number: 9409906
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: August 9, 2016
    Assignee: UNIVERSITE DE MONTREAL
    Inventors: Guy Sauvageau, Yves Gareau, Réjean Ruel, Stéphane Gingras, Iman Fares
  • PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS
    Publication number: 20160222017
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Application
    Filed: February 18, 2016
    Publication date: August 4, 2016
    Applicant: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy SAUVAGEAU, Yves GAREAU, Rejean RUEL, Stéphane GINGRAS, Iman FARES