Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, E-selectin antagonists are described and pharmaceutical compositions comprising at least one of the same.

Abstract: Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

Abstract: Implementations are described for a modular power distribution unit (PDU) for a rack-mountable power tray or power shelf. The modular PDU includes a housing defining an input face and an opposing output face, and a plurality of power cables extending to the input face. The modular PDU further includes one or more second power connectors arranged at the output face, and distribution circuitry configured to distribute power from a first power bus and a second power bus to the one or more second power connectors. The modular PDU further includes one or more fasteners configured to attach the output face of the housing to the face of the power tray or power shelf, wherein the one or more second power connectors are retained in a coupled configuration with the one or more first power connectors.

Abstract: According to an embodiment, a surge protector includes a capacitor, a switch, and a first transistor. The capacitor charges based on an input power to the surge protector. The switch turns on when the capacitor is charged to a charge threshold. The surge protector outputs the input power when the switch is turned on. The first transistor turns on when a voltage of the input power exceeds a first input voltage threshold such that the capacitor discharges to below the charge threshold and such that the switch turns off. The surge protector stops outputting the input power when the switch is turned off.

Abstract: According to an embodiment, a surge protector includes a capacitor, a switch, and a first transistor. The capacitor charges based on an input power to the surge protector. The switch turns on when the capacitor is charged to a charge threshold. The surge protector outputs the input power when the switch is turned on. The first transistor turns on when a voltage of the input power exceeds a first input voltage threshold such that the capacitor discharges to below the charge threshold and such that the switch turns off. The surge protector stops outputting the input power when the switch is turned off.

Abstract: Embodiments herein describe control circuitry for operating a PFC converter in an AC-DC power supply under light loading conditions. The embodiments herein improve the power factor by identifying an optimized phase offset (?) between an AC reference voltage and an AC reference current used to control the PFC converter. In one embodiment, the control circuitry iteratively changes the phase offset between the reference voltage and current and measures its impact on the power factor. The control circuitry then selects the phase offset that results in the best power factor to use when operating the PFC converter under light loading conditions.

Abstract: Implementations are described for a modular power distribution unit (PDU) for a rack-mountable power tray or power shelf. The modular PDU includes a housing defining an input face and an opposing output face, and a plurality of power cables extending to the input face. The modular PDU further includes one or more second power connectors arranged at the output face, and distribution circuitry configured to distribute power from a first power bus and a second power bus to the one or more second power connectors. The modular PDU further includes one or more fasteners configured to attach the output face of the housing to the face of the power tray or power shelf, wherein the one or more second power connectors are retained in a coupled configuration with the one or more first power connectors.

Abstract: A method and system for performing data processing. A request for agent software is acquired by an agent computer system from a user computer system and in response, the agent computer system retrieves the agent software from a repository of agents and migrates the retrieved agent software to the user computer system. The agent computer system acquires an itinerary and N sets of run time instructions from the user computer system. N is at least 2. The itinerary specifies a path along which the agent software is to migrate to perform a portion of the data processing on N computer systems using the N sets of run time instructions. The agent computer system provides the received itinerary and the N sets of run time instructions to the agent software at the user computer system.

Abstract: A method and data processing system for using agent software to perform data processing on multiple computer systems. The agent software is sequentially migrated from a user computer system to each system of N computer systems, after which the agent software is returned to the user computer system with a final result that includes output results obtained from execution of run time instructions in the agent software on each computer system of the N computer systems. N is at least 1.

Abstract: A method and system for performing data processing. A request for agent software is acquired by an agent computer system from a user computer system and in response, the agent computer system retrieves the agent software from a repository of agents and migrates the retrieved agent software to the user computer system. The agent computer system acquires an itinerary and N sets of run time instructions from the user computer system. N is at least 2. The itinerary specifies a path along which the agent software is to migrate to perform a portion of the data processing on N computer systems using the N sets of run time instructions. The agent computer system provides the received itinerary and the N sets of run time instructions to the agent software at the user computer system.

Abstract: A method and data processing system for using agent software to perform data processing on multiple computer systems. The agent software is sequentially migrated from a user computer system to each system of N computer systems, after which the agent software is returned to the user computer system with a final result that includes output results obtained from execution of run time instructions in the agent software on each computer system of the N computer systems. N is at least 1.

Abstract: A distributed computing system provides a data management system in communication with a software management system and enables the software applications to move to the data to be processed in a distributed computing environment. The software management system stores a plurality of computer-executable software applications thereon and is in communication with a user system for receiving a selection of one of the plurality of software applications. The software management system generates an identifier for the selected software application which is provided to the data management system, which then obtains the selected software application from the software management system based on the identifier. The obtained software application is then executed with data from a data storage system using resources from a resource system. The resource system includes a plurality of resources and a manage mechanism for managing assignment of the plurality of resources to support execution of the software application.

Abstract: A skateboard shoe having a sole with four sole pads; each sole pad having differing durometer values: a lateral pad and a toe pad comprised of a low durometer value (Shore A) material, a medial pad comprised of a moderate durometer value (Shore A) material, and a heel pad comprised of a hard durometer value (Shore A) material.

Abstract: An inflatable liner for a boot, such as a snowboard boot. An oily chalk like substance consisting of 90% sweet starch, 9% lubricant, and 1% stearate is included between two sheets of plastic that make up bladder of the liner. The bladder is attached to the EVA of the liner before the EVA is folded, stitched, heated and molded. This allows the bladder to be attached while the EVA is still flat and allows attachment to be performed by machine stitching. The bladder is partially inflated before the EVA is heated and molded. The oily chalk like substance and the partial inflation of the bladder allows the installed bladder to pass through the heating and molding steps of the EVA without the two sheets that make up the bladder melting together. The design and installation of the bladder minimizes the amount of slipping of a wearer's foot and heel within the boot.

Abstract: A valve designed to limit inadvertent operation of the valve. The valve has a shortened plunger, a collar to prevent tilt of the plunger, and a conformable ring on the valve face. The plunger is provided with a groove sized and dimensioned to partially receive the inner surface of the ring.

Abstract: A skateboard shoe having a sole with four sole pads; each sole pad having differing durometer values: a lateral pad and a toe pad comprised of a low durometer value (Shore A) material, a medial pad comprised of a moderate durometer value (Shore A) material, and a heel pad comprised of a hard durometer value (Shore A) material.

Abstract: An inflatable liner for a boot, such as a snowboard boot. An oily chalk like substance consisting of 90% sweet starch, 9% lubricant, and 1% stearate is included between two sheets of plastic that make up bladder of the liner. The bladder is attached to the EVA of the liner before the EVA is folded, stitched, heated and molded. This allows the bladder to be attached while the EVA is still flat and allows attachment to be performed by machine stitching. The bladder is partially inflated before the EVA is heated and molded. The oily chalk like substance and the partial inflation of the bladder allows the installed bladder to pass through the heating and molding steps of the EVA without the two sheets that make up the bladder melting together. The design and installation of the bladder minimizes the amount of slipping of a wearer's foot and heel within the boot.

Abstract: An inflatable liner for a boot, such as a snowboard boot. An oily chalk like substance consisting of 90% sweet starch, 9% lubricant, and 1% stearate is included between two sheets of plastic that make up bladder of the liner. The bladder is attached to the EVA of the liner before the EVA is folded, stitched, heated and molded. This allows the bladder to be attached while the EVA is still flat and allows attachment to be performed by machine stitching. The bladder is partially inflated before the EVA is heated and molded. The oily chalk like substance and the partial inflation of the bladder allows the installed bladder to pass through the heating and molding steps of the EVA without the two sheets that make up the bladder melting together. The design and installation of the bladder minimizes the amount of slipping of a wearer's foot and heel within the boot.

Abstract: A valve designed to limit inadvertent operation of the valve. The valve has a shortened plunger, a collar to prevent tilt of the plunger, and a conformable ring on the valve face. The plunger is provided with a groove sized and dimensioned to partially receive the inner surface of the ring.

Abstract: An inflatable shoe with a deflation valve designed to limit inadvertent operation of the valve and thereby limit inadvertent deflation of the shoe. The deflation valve has a shortened plunger, a collar to prevent tilt of the plunger, and a conformable ring on the valve face. The plunger is provided with a groove sized and dimensioned to partially receive the inner surface of the ring.