Patents by Inventor Indu Bhushan
Indu Bhushan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11850567Abstract: A co-rotating twin screw processor for preparing dry granules including an input zone having one or more powder feeders for feeding an input material into the processor, a steam feeder configured to introduce steam as a granulation activating agent in to the processor, a granulation zone for granulating the input material in the presence of steam to form granules, a controller configured to control operation and feed rate of at least one of the powder feeder or the steam feeder such that 2.5 to 5 percent w/w of the steam with respect to the input material is available for granulation, and a discharge zone haring a non-extruding opening for collecting dry granules.Type: GrantFiled: August 31, 2020Date of Patent: December 26, 2023Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Radhika Ghike, Vijay Kulkarni, Indu Bhushan, Himadri Sen, Babu Padmanabhan, Vinay Rao
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Patent number: 11759976Abstract: A continuous granulation system for obtaining conditioned granules is disclosed. The system comprises a processor configured to produce a continuous flow of granules at an outlet of the processor. The system also comprises a collection chamber positioned downstream from the processor and configured to collect the granules from the outlet. Further, the system comprises an air displacement device coupled to the collection chamber and configured to create a unidirectional flow of air at the outlet in a direction of the granules exiting the processor and away from the outlet. The unidirectional flow of air conditions the granules obtained in the collection chamber. A continuous granulation method and a continuous granule collection system for obtaining the conditioned granules is also disclosed.Type: GrantFiled: July 14, 2021Date of Patent: September 19, 2023Assignee: Steerlife India Private LimitedInventors: Babu Padmanabhan, Indu Bhushan, Vinay Rao
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Publication number: 20230226723Abstract: A continuous granulation system for obtaining conditioned granules is disclosed. The system comprises a processor configured to produce a continuous flow of granules at an outlet of the processor. The system also comprises a collection chamber positioned downstream from the processor and configured to collect the granules from the outlet. Further, the system comprises an air displacement device coupled to the collection chamber and configured to create a unidirectional flow of air at the outlet in a direction of the granules exiting the processor and away from the outlet. The unidirectional flow of air conditions the granules obtained in the collection chamber. A continuous granulation method and a continuous granule collection system for obtaining the conditioned granules is also disclosed.Type: ApplicationFiled: July 14, 2021Publication date: July 20, 2023Applicant: STEERLIFE INDIA PRIVATE LIMITEDInventors: Babu Padmanabhan, Indu Bhushan, Vinay Rao
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Patent number: 11576855Abstract: The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.Type: GrantFiled: August 25, 2021Date of Patent: February 14, 2023Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Babu Padmanabhan, Rakshit Shetty, Vijay Kulkarni, Himadri Sen, Indu Bhushan
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Patent number: 11465327Abstract: A fractional lobe processor comprises a barrel with heating and cooling means having two parallel intersecting bores of equal diameter, wherein the centre distance between the two bores is lesser than the diameter of the bore; a shaft coupled with a plurality of screw elements to form a screw within each bore, wherein the screws are intermeshing and form at least three zones within the barrel, the zones comprising an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a feed comprising an active substance and/or an excipient, a melt zone consisting of only fractional lobe elements for melting the active substance and/or an excipient to form a viscous mass or melt, and a discharge zone, wherein the melt zone is located before the discharge zone and after the intake zone; and wherein the melt zone has a plurality of fractional lobe elements on each shaft.Type: GrantFiled: April 24, 2017Date of Patent: October 11, 2022Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Vinay Rao, Vijay Kulkarni, Chetan Chincholi, Aravind Kumar Gurram, Babu Padmanabhan
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Publication number: 20220298020Abstract: The present disclosure relates to a method for chemically modifying particles of a bicarbonate salt in a co-rotating twin-screw extruder and chemically modified bicarbonate particles prepared therefrom. The present disclosure also relates to a method for controlling an amount of carbonate salt formed during chemical modification of bicarbonate salt particles.Type: ApplicationFiled: June 7, 2022Publication date: September 22, 2022Inventors: Indu BHUSHAN, Vinay RAO, Rakshith SHETTY
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Patent number: 11383986Abstract: The present disclosure relates to a method for chemically modifying particles of a bicarbonate salt in a co-rotating twin-screw extruder and chemically modified bicarbonate particles prepared therefrom. The present disclosure also relates to a method for controlling an amount of carbonate salt formed during chemical modification of bicarbonate salt particles.Type: GrantFiled: December 20, 2019Date of Patent: July 12, 2022Assignee: Steerlife India Private LimitedInventors: Indu Bhushan, Vinay Rao, Rakshith Shetty
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Publication number: 20220192973Abstract: The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.Type: ApplicationFiled: August 25, 2021Publication date: June 23, 2022Inventors: Babu PADMANABHAN, Rakshit SHETTY, Vijay KULKARNI, Himadri SEN, Indu BHUSHAN
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Patent number: 11247378Abstract: A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.Type: GrantFiled: April 24, 2017Date of Patent: February 15, 2022Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Babu Padmanabhan, Vinay Rao, Vijay Kulkarni, Chetan Chincholi, Radhika Ghike, Raja Ganeshan
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Patent number: 11247380Abstract: Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.Type: GrantFiled: April 2, 2019Date of Patent: February 15, 2022Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Babu Padmanabhan, Vinay Rao, Vijay Kulkarni, Chetan Chincholi, Radhika Ghike, Raja Ganeshan
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Patent number: 11247379Abstract: Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.Type: GrantFiled: April 2, 2019Date of Patent: February 15, 2022Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Babu Padmanabhan, Vinay Rao, Vijay Kulkarni, Chetan Chincholi, Radhika Ghike, Raja Ganeshan
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Publication number: 20220041459Abstract: The present disclosure relates to a method for chemically modifying particles of a bicarbonate salt in a co-rotating twin-screw extruder and chemically modified bicarbonate particles prepared therefrom. The present disclosure also relates to a method for controlling an amount of carbonate salt formed during chemical modification of bicarbonate salt particles.Type: ApplicationFiled: December 20, 2020Publication date: February 10, 2022Inventors: Indu BHUSHAN, Vinay RAO, Rakshith SHETTY
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Patent number: 11219594Abstract: The present invention relates to effervescent compositions of Metformin and optionally other anti-diabetic agents and processes for preparation thereof. More particularly provides an effervescent composition comprising Metformin, an acid and a base such that the composition is free of affirmatively added binders and granulating solvents. The effervescent composition of the present invention has retained carbon dioxide content of at least 90% of the input blend.Type: GrantFiled: December 12, 2016Date of Patent: January 11, 2022Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Vijay Kulkarni, Rakshith Shetty
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Publication number: 20210046439Abstract: The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.Type: ApplicationFiled: August 31, 2020Publication date: February 18, 2021Inventors: Radhika Ghike, Vijay Kulkarni, Indu Bhushan, Himadri Sen, Babu Padmanabhan, Vinay Rao
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Patent number: 10792634Abstract: A process for preparing granules is disclosed. The process comprises the steps of feeding the input material for granulation in a processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and collecting the granules from a discharge zone of the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.Type: GrantFiled: August 1, 2016Date of Patent: October 6, 2020Assignee: Intel CorporationInventors: Radhika Ghike, Vijay Kulkarni, Indu Bhushan, Himadri Sen, Babu Padmanabhan, Vinay Rao
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Publication number: 20200138719Abstract: The present invention relates to a granular composition comprising essentially Tenofovir, wherein the composition is devoid of an excipient. Tenofovir granules of the present invention are prepared in twin-screw processor such that the content of total impurities in the prepared granules is less than 2.0%.Type: ApplicationFiled: January 6, 2020Publication date: May 7, 2020Applicant: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu BHUSHAN, Vinay RAO, Radhika GHIKE
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Patent number: 10561614Abstract: The present invention relates to a granular composition comprising essentially Tenofovir, wherein the composition is devoid of an excipient. Tenofovir granules of the present invention are prepared in twin-screw processor such that the content of total impurities in the prepared granules is less than 2.0%.Type: GrantFiled: January 26, 2018Date of Patent: February 18, 2020Assignee: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Vinay Rao, Radhika Ghike
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Publication number: 20190263042Abstract: Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.Type: ApplicationFiled: April 2, 2019Publication date: August 29, 2019Inventors: Indu BHUSHAN, Babu PADMANABHAN, Vinay RAO, Vijay KULKARNI, Chetan CHINCHOLI, Radhika GHIKE, Raja GANESHAN
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Publication number: 20190263043Abstract: Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.Type: ApplicationFiled: April 2, 2019Publication date: August 29, 2019Inventors: Indu Bhushan, Babu Padmanabhan, Vinay Rao, Vijay Kulkarni, Chetan Chincholi, Radhika Ghike, Raja Ganeshan
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Publication number: 20190134875Abstract: A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.Type: ApplicationFiled: April 24, 2017Publication date: May 9, 2019Applicant: STEERLIFE INDIA PRIVATE LIMITEDInventors: Indu Bhushan, Babu Padmanabhan, Vinay Rao, Vijay Kulkarni, Chetan Chincholi, Radhika Ghike, Raja Ganeshan