Patents by Inventor Ines Batinic-Haberle

Ines Batinic-Haberle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS, COMPOSITIONS, AND KITS FOR TREATING AND/OR PREVENTING A SIDE EFFECT ASSOCIATED WITH RADIATION AND/OR CHEMOTHERAPY EXPOSURE
    Publication number: 20220193090
    Abstract: Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.
    Type: Application
    Filed: March 10, 2022
    Publication date: June 23, 2022
    Inventors: Kathleen Ashcraft, Mark Dewhirst, Ines Batinic-Haberle, James D. Crapo
  • Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same
    Patent number: 11344574
    Abstract: Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: May 31, 2022
    Assignee: Duke University
    Inventors: Ines Batinic-Haberle, Artak Tovmasyan, Ivan Spasojevic
  • Methods, compositions, and kits for treating and/or preventing a side effect associated with radiation and/or chemotherapy exposure
    Patent number: 11285162
    Abstract: Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: March 29, 2022
    Assignees: BioMimetix JV, LLC, Duke University
    Inventors: Kathleen Ashcraft, Mark Dewhirst, Ines Batinic-Haberle, James D. Crapo
  • FLUORO SUBSTITUTED PORPHYRIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
    Publication number: 20210361702
    Abstract: Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.
    Type: Application
    Filed: September 26, 2018
    Publication date: November 25, 2021
    Inventors: Ines Batinic-Haberle, Artak Tovmasyan, Ivan Spasojevic
  • Methods of treating pruritus
    Patent number: 11065259
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 20, 2021
    Assignees: Duke University, BioMimetix JV, LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • METHODS, COMPOSITIONS, AND KITS FOR TREATING AND/OR PREVENTING A SIDE EFFECT ASSOCIATED WITH RADIATION AND/OR CHEMOTHERAPY EXPOSURE
    Publication number: 20210106594
    Abstract: Described herein are methods, compositions, and kits for treating and/or preventing in a subject one or more side effects associated with radiation and/or chemotherapy exposure, including methods, compositions and kits that include an active agent at a low dose. In some embodiments, methods, compositions, and kits for treating and/or preventing tissue damage in a subject are provided, including methods, compositions and kits that include an active agent at a low dose.
    Type: Application
    Filed: April 4, 2018
    Publication date: April 15, 2021
    Inventors: Kathleen Ashcraft, Mark Dewhirst, Ines Batinic-Haberle, James D. Crapo
  • METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS
    Publication number: 20190330220
    Abstract: Described herein are methods and intermediates useful for making substituted porphyrins, including Mn(III) orthoN-butoxyethylpyridylporphyrin, and compositions comprising the same. In some embodiments, a method of the present invention provides a composition having a certain percentage or yield (e.g., at least 80%, 85%, 90%, or 95% by weight) of a compound of the present invention.
    Type: Application
    Filed: December 19, 2017
    Publication date: October 31, 2019
    Inventors: Ines Batinic-Haberle, Artak Tovmasyan, Zrinka Rajic Dzolic, Ivan Spasojevic, Christopher Allen Lee
  • METHODS OF TREATING PRURITUS
    Publication number: 20180353516
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 13, 2018
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Methods of treating pruritus
    Patent number: 10080759
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: September 25, 2018
    Assignees: Duke University, BioMimetix J.V., LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • METHODS OF TREATING PRURITUS
    Publication number: 20160324868
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Application
    Filed: January 21, 2015
    Publication date: November 10, 2016
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Substituted porphyrins
    Patent number: 9289434
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: March 22, 2016
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • SUBSTITUTED PORPHYRINS
    Publication number: 20150344509
    Abstract: Substituted metalloporphyrin compounds are described, along with pharmaceutical compositions containing the same, and methods of use thereof in protecting cells from oxidant-induced toxicity and pathological conditions such as inflammatory lung disease, neurodegenerative conditions, radiation injury, cancer, diabetes, cardiac conditions and sickle cell disease. Mn(III) porphyrins bearing oxygen atoms within side chains are particularly described.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 3, 2015
    Inventors: Ines Batinic-Haberle, Irwin Fridovich, Ivan Spasojevic
  • SUBSTITUTED PORPHYRINS
    Publication number: 20150231150
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Application
    Filed: December 18, 2014
    Publication date: August 20, 2015
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polivina Jolicia F. Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • Substituted porphyrins
    Patent number: 9096628
    Abstract: Substituted metalloporphyrin compounds are described, along with pharmaceutical compositions containing the same, and methods of use thereof in protecting cells from oxidant-induced toxicity and pathological conditions such as inflammatory lung disease, neurodegenerative conditions, radiation injury, cancer, diabetes, cardiac conditions and sickle cell disease. Mn(III) porphyrins bearing oxygen atoms within side chains are particularly described.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: August 4, 2015
    Assignee: Duke University
    Inventors: Ines Batinic-Haberle, Irwin Fridovich, Ivan Spasojevic
  • Method for fluorescent staining of cellular and intracellular membranes
    Patent number: 9034596
    Abstract: The method for fluorescent staining of cellular and intracellular membranes includes contacting a cell sample, such as a cell culture, with a fluorescent probe including Zn(II) meso-tetrakis(N-n-hexylpyridinium-4-yl)porphyrin tetrachloride (ZnTnHex-4-PyPCl4). The fluorescent probe is an amphiphilic, water-soluble compound. The fluorescent probe does not interfere with cell culture media components or other staining products. The fluorescent probe is not harmful to cells.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: May 19, 2015
    Assignee: KUWAIT UNIVERSITY
    Inventors: Ludmil Tzvetanov Benov, Rima Abdul Ghani Ezzeddine, Anwar Gh. A. Gh. Albanaw, Ines Batinic-Haberle, James D. Craik, Artak Tovmasyan
  • Substituted porphyrins
    Patent number: 8946202
    Abstract: The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: February 3, 2015
    Assignees: Aeolus Sciences, Inc., National Jewish Health, Duke University
    Inventors: James D. Crapo, Brian J. Day, Michael P. Trova, Polvina Jolicia Gauuan, Douglas B. Kitchen, Irwin Fridovich, Ines Batinic-Haberle
  • METHOD OF ACTIVATION OF OXAZAPHOSPHORINES
    Publication number: 20140243294
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: DUKE UNIVERSITY
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • Cancer therapy
    Patent number: 8765729
    Abstract: The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: July 1, 2014
    Assignees: Aeolus Sciences, Inc., Duke University, National Jewish Medical and Research Center
    Inventors: James D. Crapo, Brian J. Day, Ines Batinic-Haberle, Richard Gammans, Zeljko Vusjaskovic
  • Method of activation of oxazaphosphorines
    Patent number: 8759324
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: June 24, 2014
    Assignee: Duke University
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • SUBSTITUTED PORPHYRINS
    Publication number: 20140080797
    Abstract: Substituted metalloporphyrin compounds are described, along with pharmaceutical compositions containing the same, and methods of use thereof in protecting cells from oxidant-induced toxicity and pathological conditions such as inflammatory lung disease, neurodegenerative conditions, radiation injury, cancer, diabetes, cardiac conditions and sickle cell disease. Mn(III) porphyrins bearing oxygen atoms within side chains are particularly described.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: Duke University
    Inventors: Ines Batinic-Haberle, Irwin Fridovich, Ivan Spasojevic