Patents by Inventor Ioannis Bossis

Ioannis Bossis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYIONIC PAPILLOMA VIRUS-LIKE PARTICLE (VLP) VACCINES
    Publication number: 20170327543
    Abstract: The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids. In a more specific embodiment, a chimeric bovine papillomavirus VLP comprises the L1 protein, wherein the amino acid sequence EEEEEEEEC is inserted into the HI loop of the L1 protein.
    Type: Application
    Filed: January 31, 2017
    Publication date: November 16, 2017
    Inventors: Raphael Paul Viscidi, Ioannis Bossis
  • Polyionic papilloma virus-like particle (VLP) vaccines
    Patent number: 9580474
    Abstract: The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids. In a more specific embodiment, a chimeric bovine papillomavirus VLP comprises the L1 protein, wherein the amino acid sequence EEEEEEEEC is inserted into the HI loop of the L1 protein.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: February 28, 2017
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Raphael Paul Viscidi, Ioannis Bossis
  • Avian adenoassociated virus and uses thereof
    Patent number: 9238800
    Abstract: The present invention provides an Avian adeno-associated vims (AAAV) vims and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles. Methods of isolating the AAAV are provided.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 19, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Ioannis Bossis, John A. Chiorini
  • Bovine adeno-associated viral (BAAV) vector and uses thereof
    Patent number: 9193769
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: November 24, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • Avian Adenoassociated Virus and Uses Thereof
    Publication number: 20150152393
    Abstract: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 4, 2015
    Inventors: Ioannis Bossis, John A. Chiorini
  • Avian adenoassociated virus and uses thereof
    Patent number: 8927269
    Abstract: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles. Methods of isolating the AAAV are provided.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: January 6, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Ioannis Bossis, John A. Chiorini
  • Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof
    Publication number: 20140221636
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Application
    Filed: February 13, 2014
    Publication date: August 7, 2014
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • Bovine adeno-associated viral (BAAV) vector and uses thereof
    Patent number: 8685722
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: April 1, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • POLYIONIC PAPILLOMA VIRUS-LIKE PARTICLE (VLP) VACCINES
    Publication number: 20140050753
    Abstract: The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids. In a more specific embodiment, a chimeric bovine papillomavirus VLP comprises the L1 protein, wherein the amino acid sequence EEEEEEEEC is inserted into the HI loop of the L1 protein.
    Type: Application
    Filed: September 8, 2011
    Publication date: February 20, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Raphael Paul Viscidi, Ioannis Bossis
  • Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof
    Publication number: 20120253018
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Application
    Filed: March 6, 2012
    Publication date: October 4, 2012
    Applicants: Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • Bovine adeno-associated viral (BAAV) vector and uses thereof
    Patent number: 8137960
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: March 20, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael Schmidt, Ioannis Bossis, John A. Chiorini
  • Avian adenoassociated virus and uses thereof
    Publication number: 20070092866
    Abstract: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles. Methods of isolating the AAAV are provided.
    Type: Application
    Filed: May 18, 2004
    Publication date: April 26, 2007
    Inventors: Ioannis Bossis, John Chiorini
  • Bovine adeno-associated viral (baav) vector and uses thereof
    Publication number: 20070072282
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Application
    Filed: December 6, 2004
    Publication date: March 29, 2007
    Inventors: John Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Pasquale