Patents by Inventor Ioannis Danias

Ioannis Danias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glaucoma treatment
    Patent number: 11478536
    Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: October 25, 2022
    Assignees: The Research Foundation for The State University of New York, Icahn School of Medicine at Mount Sinai
    Inventors: Ioannis Danias, Oscar A. Candia, Rosana Gerometta
  • Glaucoma treatment
    Patent number: 10946076
    Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 16, 2021
    Assignees: The Research Foundation for The State University of New York, Icahn School of Medicine at Mount Sinai
    Inventors: Ioannis Danias, Oscar A. Candia, Rosana Gerometta
  • GLAUCOMA TREATMENT
    Publication number: 20200268858
    Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 27, 2020
    Applicants: The Research Foundation for The State University of New York, Icahn School of Medicine at Mount Sinai
    Inventors: Ioannis DANIAS, Oscar A. CANDIA, Rosana GEROMETTA
  • Bioengineered human trabecular meshwork for biological applications
    Patent number: 9506907
    Abstract: The present invention relates to methods of manufacture and utility of an artificial trabecular meshwork [TM] that utilizes micro- and nanofabricated materials bioengineered to mimic the structure and function of native outflow system of the eye.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: November 29, 2016
    Assignee: The Research Foundation of State University of New York
    Inventors: Magnus Bergkvist, Sara Brenner, Ioannis Danias, Susan Sharfstein, Yubing Xie, Alison Gracias, Karen Y. Torrejon
  • Method for screening a drug in retinal tissue
    Patent number: 9134300
    Abstract: The subject matter disclosed herein pertains to a method for screening drugs using second-harmonic generation microscopy. The tissue is scanned with a pulsed laser light which has an excitation wavelength. At least some of microtubules within the tissue produce generated light with a second-harmonic wavelength that is half the excitation wavelength. A microtubule pattern within the tissue is determined based on an analysis of the generated second-harmonic wavelength.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: September 15, 2015
    Assignees: Research Foundation of the City University of New York, Research Foundation of the State University of New York
    Inventors: Ioannis Danias, Hyungsik Lim
  • METHOD FOR SCREENING A DRUG IN RETINAL TISSUE
    Publication number: 20140295481
    Abstract: The subject matter disclosed herein pertains to a method for screening drugs using second-harmonic generation microscopy. The tissue is scanned with a pulsed laser light which has an excitation wavelength. At least some of microtubules within the tissue produce generated light with a second-harmonic wavelength that is half the excitation wavelength. A microtubule pattern within the tissue is determined based on an analysis of the generated second-harmonic wavelength.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Applicants: Research Foundation of the City University of New York, Research Foundation of the State University of New York
    Inventors: Ioannis Danias, Hyungsik Lim
  • BIOENGINEERED HUMAN TRABECULAR MESHWORK FOR BIOLOGICAL APPLICATIONS
    Publication number: 20140038221
    Abstract: The present invention relates to methods of manufacture and utility of an artificial trabecular meshwork [TM] that utilizes micro- and nanofabricated materials bioengineered to mimic the structure and function of native outflow system of the eye.
    Type: Application
    Filed: February 19, 2013
    Publication date: February 6, 2014
    Inventors: Magnus Bergkvist, Sara Ann Brenner, Ioannis Danias, Susan Tina Sharfstein, Yubing Xie