Patents by Inventor Ira Herskowitz

Ira Herskowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Origin of replication complex genes
    Patent number: 5614618
    Abstract: Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 25, 1997
    Assignees: Cold Spring Harbor Laboratory, The Regents of the University of California
    Inventors: Bruce W. Stillman, Stephen P. Bell, Ryuji Kobayashi, Jasper Rine, Margit Foss, Francis J. McNally, Patricia Laurenson, Ira Herskowitz, Joachim Li, Kimberly Gavin, Masumi Hidaka
  • Origin of replication complex genes and methods of using the same
    Patent number: 5589341
    Abstract: Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 31, 1996
    Assignees: Cold Spring Harbor Laboratory, The Regents of the University of California
    Inventors: Bruce W. Stillman, Stephen P. Bell, Ryuji Kobayashi, Jasper Rine, Margit Foss, Francis J. McNally, Patricia Laurenson, Ira Herskowitz, Joachim Li, Kimberly Gavin, Masumi Hidaka
  • Cloning and expression of yeast STE13 and Dpp2 genes encoding dipeptidyl aminopeptidase A and B
    Patent number: 4977085
    Abstract: A method is provided for expressing the proteases dipeptidyl aminopeptidases A and B which are useful for processing precursor proteins. Genes controlling these proteases may be insdrted into appropriate vectors and transformed into cultures. The proteases may either be utilized to process precursor proteins in vivo or may be extracted from cultures and used to process precursor proteins in vitro.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: December 11, 1990
    Assignee: The Board of Regents of the Univ. of California
    Inventors: George Sprague, Ira Herskowitz, Jeremy Thorner, David Julius, Lindley Blair, Anthony Brake
  • E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
    Patent number: 4546082
    Abstract: A method for producing secretable and processable biologically useful polypeptides in yeast is provided utilizing vectors including at least a segment of the gene coding for S. cerevisiae alpha-factor.
    Type: Grant
    Filed: June 17, 1982
    Date of Patent: October 8, 1985
    Assignee: Regents of the Univ. of California
    Inventors: Janet Kurjan, Ira Herskowitz