Patents by Inventor Irfan Ali-Khan

Irfan Ali-Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Self-quenching activatable COX-2-specific multi-modal molecular probes for diagnosis of cancers, inflammation, and immune system disorders
    Patent number: 9283289
    Abstract: Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In particular, an activatable probe comprises a fluorescent moiety comprising a fluorophore attached to a compound having selective affinity for COX-2, and a removable fluorescence quencher linked to the fluorescent moiety by a cleavable linker. Upon delivery to a recipient subject, the activatable probe is localized and concentrated in tissues and cells with elevated levels of COX-2. The linker is cleaved to release the fluorescence quencher.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 15, 2016
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO
    Inventors: Jayakumar Rajadas, Emilio Gonzalez, Hyejun Ra, Irfan Ali-Khan, Christopher Contag
  • SELF-QUENCHING ACTIVATABLE COX-2-SPECIFIC MULTI-MODAL MOLECULAR PROBES FOR DIAGNOSIS OF CANCERS, INFLAMMATION, AND IMMUNE SYSTEM DISORDERS
    Publication number: 20140004050
    Abstract: Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In particular, an activatable probe comprises a fluorescent moiety comprising a fluorophore attached to a compound having selective affinity for COX-2, and a removable fluorescence quencher linked to the fluorescent moiety by a cleavable linker. Upon delivery to a recipient subject, the activatable probe is localized and concentrated in tissues and cells with elevated levels of COX-2. The linker is cleaved to release the fluorescence quencher.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 2, 2014
    Inventors: Jayakumar Rajadas, Emilio Gonzalez, Hyejun Ra, Irfan Ali-Khan, Christopher Contag