Abstract: Disclosed is a system for gaining mechanistic insights into action of a drug using in-silico techniques. The system is communicably coupled to a phenotype ontological databank; wherein the system comprises a processor communicably coupled to a memory. The processor is configured to receive a first input of the drug, receive a second input relating to at least one phenotype associated with the drug, identify targets of the drug to obtain a drug target list, determine phenotypic targets of the drug, compare the drug target list with the phenotypic targets of the drug to identify a plurality of overlapping targets therebetween, generate a Drug-Target-Phenotype (DTP) network using the plurality of overlapping targets, compute relevant pathways by performing Signaling Pathway Impact Analysis (SPIA) for the plurality of overlapping targets, generate a Pathway-Target-Phenotype (PTP) network, and compute mechanistic insights into the action of the drug from the analysis of PTP network.

Abstract: A system for enabling in-silico phenotypic screening of drugs, the system is communicably coupled to a phenotype ontological databank. The system include a processor communicably coupled to a memory.

Abstract: A system for screening phenotypic targets associated with a disease using in-silico techniques. The system communicably coupled to a phenotype ontological databank including a plurality of phenotypes and phenotypic targets associated with each of the plurality of phenotypes; wherein the system includes a processor communicably coupled to a memory.