Patents by Inventor Irina Velikyan

Irina Velikyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of Ge/Ga generator eluate from Fe(III) intended to improve specific radioactivity of Ga-based radiopharmaceuticals
    Patent number: 9790097
    Abstract: The present invention provides a method of purifying 68Ge/68Ga generator produced 68Ga from Fe (III). The invention further relates to an automated system within an existing Gallea Synthia prototype that provides purification 68Ga from various cations and preconcentrations of 68Ga. In general, the present invention further depicts the use of an automated system for the production of 68Ga-radiolabelled PET tracers with high specific radioactivity and a kit for purifying 68Ge/68Ga generator produced 68Ga from Fe (III).
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 17, 2017
    Assignee: GE Healthcare Limited
    Inventors: Bengt Langstrom, Irina Velikyan
  • Purification of 68Ge/68Ga Generator Eluate From Fe(III) Intended To Improve Specific Radioactivity Of 68Ga-based Radiopharmaceuticals
    Publication number: 20170029287
    Abstract: The present invention provides a method of purifying 68Ge/68Ga generator produced 68Ga from Fe (III). The invention further relates to an automated system within an existing Gallea Synthia prototype that provides purification 68Ga from various cations and preconcentrations of 68Ga. In general, the present invention further depicts the use of an automated system for the production of 68Ga-radiolabelled PET tracers with high specific radioactivity and a kit for purifying 68Ge/68Ga generator produced 68Ga from Fe (III).
    Type: Application
    Filed: September 23, 2016
    Publication date: February 2, 2017
    Inventors: Bengt Langstrom, Irina Velikyan
  • Purification of Ge/Ga generator eluate from Fe(III) intended to improve specific radioactivity of Ga-based radiopharmaceuticals
    Patent number: 9487410
    Abstract: The present invention provides a method of purifying 68Ge/68Ga generator produced 68Ga from Fe (III). The invention further relates to an automated system within an existing Gallea Synthia prototype that provides purification 68Ga from various cations and preconcentrations of 68Ga. In general, the present invention further depicts the use of an automated system for the production of 68Ga-radiolabelled PET tracers with high specific radioactivity and a kit for purifying 68Ge/68Ga generator produced 68Ga from Fe (III).
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: November 8, 2016
    Assignee: GE Healthcare Limited
    Inventors: Bengt Langstrom, Irina Velikyan
  • Labelled biotin conjugates
    Patent number: 8846001
    Abstract: The present invention provides radioactive gallium complexes which comprise DOTA-biotin conjugates, incorporating a linker group. Also described are radiopharmaceutical compositions, and methods and uses of the complexes for in vivo imaging involving pre-targeting with avidin.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: September 30, 2014
    Assignees: GE Healthcare Limited, Hammersmith Imanet Limited
    Inventors: Irina Velikyan, Elisabeth Blom, Bengt Langstrom
  • Method for obtaining Ga
    Patent number: 8663597
    Abstract: The present invention relates to a method of obtaining 68Ga from a 68Ge/68Ga radioisotope generator and a method of preparing 68Ga-radiolabelled complexes using the obtained 68Ga. The method comprises elution of the generator with an aqueous chloride ion solution. The invention further relates to an apparatus for carrying out the 68Ga metal complex formation.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: March 4, 2014
    Assignees: GE Healthcare Limited, Hammersmith Imanet Limited
    Inventors: Johan Ulin, Bengt Langstrom, Irina Velikyan
  • LABELLED BIOTIN CONJUGATES
    Publication number: 20120177569
    Abstract: The present invention provides radioactive gallium complexes which comprise DOTA-biotin conjugates, incorporating a linker group. Also described are radiopharmaceutical compositions, and methods and uses of the complexes for in vivo imaging involving pre-targeting with avidin.
    Type: Application
    Filed: September 16, 2010
    Publication date: July 12, 2012
    Applicants: HAMMERSMITH IMANET LMITED, GE HEALTHCARE LIMITED
    Inventors: Irina Velikyan, Elisabeth Blom, Bengt Langstrom
  • METHOD FOR OBTAINING 68GA
    Publication number: 20120178902
    Abstract: The present invention relates to a method of obtaining 68Ga from a 68Ge/68Ga radioisotope generator and a method of preparing 68Ga-radiolabelled complexes using the obtained 68Ga. The method comprises elution of the generator with an aqueous chloride ion solution. The invention further relates to an apparatus for carrying out the 68Ga metal complex formation.
    Type: Application
    Filed: September 21, 2010
    Publication date: July 12, 2012
    Inventors: Johan Ulin, Bengt Langstrom, Irina Velikyan
  • Microwave method for preparing radiolabelled gallium complexes
    Patent number: 8007766
    Abstract: The present invention relates to a method of producing radiolabelled gallium complexes that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: August 30, 2011
    Assignee: GE Healthcare Limited
    Inventors: Irina Velikyan, Bengt Langstrom
  • RADIOLABELED GALLIUM COMPLEXES, METHODS FOR SYNTHESIS AND USE FOR PET IMAGING OF EGFR EXPRESSION IN MALIGNANT TUMORS
    Publication number: 20110117012
    Abstract: The Invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
    Type: Application
    Filed: January 21, 2011
    Publication date: May 19, 2011
    Applicant: GE HEALTHCARE LIMITED
    Inventors: VLADIMIR TOLMACHEV, BENGT LANGSTROM, ASA LILJEGREN SUNDBERG, IRINA VELIKYAN
  • PURIFICATION OF 68GE/68GA GENERATOR ELUATE FROM FE(III) INTENDED TO IMPROVE SPECIFIC RADIOACTIVITY OF 68GA-BASED RADIOPHARMACEUTICALS
    Publication number: 20100275734
    Abstract: The present invention provides a method of purifying 68Ge/68Ga generator produced 68Ga from Fe (III). The invention further relates to an automated system within an existing Gallea Synthia prototype that provides purification 68Ga from various cations and preconcentrations of 68Ga. In general, the present invention further depicts the use of an automated system for the production of 68Ga-radiolabelled PET tracers with high specific radioactivity and a kit for purifying 68Ge/68Ga generator produced 68Ga from Fe (III).
    Type: Application
    Filed: December 1, 2008
    Publication date: November 4, 2010
    Inventors: Bengt Langstrom, Irina Velikyan
  • 68Ga-Labelling of a Free and Macromolecule Conjugated Macrocyclic Chelator at Ambient Temperature
    Publication number: 20100256331
    Abstract: The present invention relates to a method of producing radiolabelled gallium complexes at ambient temperature that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging.
    Type: Application
    Filed: August 29, 2007
    Publication date: October 7, 2010
    Applicant: GE Healthcare Limited
    Inventors: Irina Velikyan, Bengt Langstrom
  • 68GA-Labeled Peptide-Based Radiopharmaceuticals
    Publication number: 20100233082
    Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
    Type: Application
    Filed: August 28, 2007
    Publication date: September 16, 2010
    Inventors: Bengt Langstrom, Irina Velikyan, Mats Bergstrom, Orjan Lindhe
  • Method of obtaining gallium-68 and use thereof and device for carrying out said method
    Publication number: 20070031329
    Abstract: The present invention relates to a method of obtaining from a 68Ge/68Ga generator and a method of producing 68Ga-radiolabelled complexes using the obtained 68Ga. The invention further relates to a kit, which could be used to obtain 68Ga and a kit, which could be used for the production of 68Ga-radiolabelled complexes.
    Type: Application
    Filed: April 8, 2004
    Publication date: February 8, 2007
    Inventors: Irina Velikyan, Bengt Langstrom, Gerd Beyer
  • Microwave method for preparing radiolabelled gallium complexes
    Publication number: 20070027307
    Abstract: The present invention relates to a method of producing radiolabelled gallium complexes that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging.
    Type: Application
    Filed: April 8, 2004
    Publication date: February 1, 2007
    Inventors: Irina Velikyan, Bemgt Langstrom
  • Radiolabeled gallium complexes, methods for synthesis and use for PET imaging of EGFR expression in malignant tumors
    Publication number: 20060188441
    Abstract: Methods for labeling synthesis of radiolabeled gallium complex by microwave activation are provided. The resultant gallium-isotope labeled compounds are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). A method for imaging EGFR overexpression in tumors using PET is also provided.
    Type: Application
    Filed: February 21, 2006
    Publication date: August 24, 2006
    Inventors: Vladimir Tolmachev, Bengt Langstrom, Asa Sundberg, Irina Velikyan