Abstract: An implantable and biodegradable polymeric matrix with reduced foreign body response for the regeneration and/or reconstruction and/or creation of soft and connective tissue and/or organs is provided. The matrix has a density equal to or lower than 40 kg/m3, a plurality of local thicknesses of a solid component with an arithmetic mean equal to or lower than 95 ?m, an average size of pores/void spaces equal to or lower than 15,000 ?m, a surface roughness Ra of the solid component with an arithmetic mean equal to or lower than 3 ?m; and a contact angle ? of the solid component lower than 110°, preferably in the range 10° to 90°, and more preferably in the range 30° to 60°.

Abstract: An implantable biodegradable medical device arranged for breast reconstruction and/or augmentation, made of an interconnected porous structured polymeric matrix and belonging to the family of poly(urea urethane)s. The porous structured polymeric matrix of the medical device comprises a plurality of three dimensional channels, drilled by means of heated tools, three-dimensionally propagating through the polymeric matrix ad interconnected with the porous structure of the polymeric matrix. The polymeric matrix comprises high to-medium molecular weight hydrophobic biodegradable amorphous soft segments polyols, having average molecular weight comprised between 20?000 and 60?000 Da,—hydrophilic polyalkoxide polyols, of average molecular weight comprised between 2?000 and 15?000 Da, and low molecular weight polyisocyanates and polyols, whose average molecular weights range between 15 and 200 Da.

Abstract: An implantable biodegradable medical device arranged for breast reconstruction and/or augmentation, made of an interconnected porous structured polymeric matrix and belonging to the family of poly(urea urethane)s. The porous structured polymeric matrix of the medical device comprises a plurality of three dimensional channels, drilled by means of heated tools, three-dimensionally propagating through the polymeric matrix ad interconnected with the porous structure of the polymeric matrix.

Abstract: The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a “scaffold” for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved hydrophilia, which involves the use of two types of catalyst, one for the cross-linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent.

Abstract: A multiple energy storage device fuel gauge is described for a device having a power system with multiple heterogeneous energy storage devices. The fuel gauge keeps track of a present state of multiple heterogeneous energy storage devices simultaneously. The fuel gauge implements collective measurement of voltage and current of the multiple heterogeneous energy storage devices via shared circuitry to determine status information, such as state of charge (SOC) and internal resistance values. A controller of the fuel gauge uses various measurements and energy storage device-specific parameters to compute status values indicative of the state of each energy storage device. The status values are maintained by the fuel gauge and exposed to other system components to facilitate power management decisions. A communication bus is used to communicate between the fuel gauge and System components, and a software API may be exposed to facilitate access to various energy storage device specific information.

Abstract: The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a “scaffold” for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved hydrophilia, which involves the use of two types of catalyst, one for the cross-linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent.

Abstract: Hydrogels based on gelatin crosslinked with N,N?-methylenebisacrylamide (MBA) are disclosed. The hydrogels according to the invention are useful for cell culture, growth and proliferation, for the controlled release of bioactive molecules, and to promote tissue regeneration.