Abstract: The present invention relates to a compound having the general Formula (I): wherein: m and n are each independently an integer from 1 to 6; X1-X3 and Y1-Y3 are each independently O or S; R1-R3 are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and R is (CH2)x-C(?O)NR?—(CH2)y-NR?R? whereas: x and y are each independently an integer from 1 to 6; and R? and R? are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and to an antibody comprising an antigen recognition region capable of specifically binding the above compound.

Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

Abstract: A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed.

Abstract: The present invention relates to a compound having the general Formula (I): wherein: m and n are each independently an integer from 1 to 6; X1-X3 and Y1-Y3 are each independently O or S; R1-R3 are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and R is (CH2)x—C(?O)NR?—(CH2)y—NR?R? whereas: x and y are each independently an integer from 1 to 6; and R? and R? are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and to an antibody comprising an antigen recognition region capable of specifically binding the above compound.

Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

Abstract: Method and system for footprinting a nucleic acid molecule. A sample consists of a nucleic acid molecule in an environment in which —OH radicals are generated when the environment is irradiated with an X-ray beam having an intensity less than 109 photons sec?1 mm?2 for an amount of time less than 1,000 msec. The sample is then irradiated with an X-ray beam having an intensity less than 109 photons sec?1 mm?2 for an amount of time less than 1,000 msec so as to generate —OH radicals in the environment. Fragmentation of the nucleic acid molecule is then detected.

Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

Abstract: Method and system for footprinting a nucleic acid molecule. A sample consists of a nucleic acid molecule in an environment in which .OH radicals are generated when the environment is irradiated with an X-ray beam having an intensity less than 109 photons sec−1 mm−2 for an amount of time less than 1,000 msec. The sample is then irradiated with an X-ray beam having an intensity less than 109 photons sec−1 mm−2 for an amount of time less than 1,000 msec so as to generate .OH radicals in the environment. Fragmentation of the nucleic acid molecule is then detected.

Abstract: A method for trapping of a plurality of charged particles in a charged particle trap. The trap includes first and second electrode mirrors having a common optical axis, the mirrors being arranged in alignment at two extremities thereof. The mirrors are capable, when voltage is applied thereto, of creating respective electric fields defined by key field parameters. The electric fields are configured to reflect charged particles causing their oscillation between the mirrors. The method includes introducing into the trap, along the optical axis, the plurality of charged particles as a beam having pre-determined key beam parameters. The method further includes choosing the key field parameters for at least one of the mirrors such as to induce bunching among charged particles in the beam.

Abstract: A method for trapping of a plurality of charged particles in a charged particle trap. The trap includes first and second electrode mirrors having a common optical axis, the mirrors being arranged in alignment at two extremities thereof. The mirrors are capable, when voltage is applied thereto, of creating respective electric fields defined by key field parameters. The electric fields are configured to reflect charged particles causing their oscillation between the mirrors. The method includes introducing into the trap, along the optical axis, the plurality of charged particles as a beam having pre-determined key beam parameters. The method further includes choosing the key field parameters for at least one of the mirrors such as to induce bunching among charged particles in the beam.