Patents by Inventor Irmgard Bottcher

Irmgard Bottcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4975466
    Abstract: Pharmaceutical preparations for topical, i.e. dermal, application that contain as active ingredient a compound of the formula I ##STR1## especially 2-hydroxy-5-[(RS)-1-hydroxy-2-[[(RS)-1-(p-methoxyphenyl)-prop-2-yl]-amino] -ethyl]-formanilide (formoterol), or one of its pharmaceutically acceptable salts, especially its semifumarate, are proposed for the treatment of inflammatory skin diseases.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: December 4, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Irmgard Bottcher, Werner Pignat
  • Patent number: 4528298
    Abstract: Imidazole derivatives of the formula ##STR1## wherein AR.sub.1 and AR.sub.2 each independently is phenyl, optionally substituted by halogen atoms, alkyl residues, alkoxy residues; or dialkylamino residues; pyridyl, furyl; or thienyl;R.sub.1 is hydrogen; alkyl of 1-6 carbon atoms optionally; substituted by hydroxy groups, alkoxy groups, or acyloxy groups; benzyl; tetrahydropyran-2-yl; or tetrahydrofuran-2-yln is 0, 1 or 2; andZ is phenyl optionally substituted by halogen atoms, alkyl groups, alkoxy groups, nitro groups, amino, acylamino groups or trifluoromethyl groups; pyridyl; N-oxypyridyl; pyrimidinyl; thiazolyl; or thienyl, and the physiologically acceptable salts thereof with acids,have valuable pharmacological activity, e.g., antiinflammatory activity.
    Type: Grant
    Filed: July 22, 1983
    Date of Patent: July 9, 1985
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Irmgard Bottcher
  • Patent number: 4457927
    Abstract: Pyrido[2,1-b]quinazolinones of the formula ##STR1## wherein X is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl, carboxy, carboxy in the form of a salt thereof with a physiologically compatible base, carboxy esterified with a physiologically acceptable alcohol or carboxy amidated with a physiologically acceptable amine;R.sub.1 is hydrogen or methyl; andR.sub.2 through R.sub.5 are independently each hydrogen, halogen, alkyl of 1-4 carbon atoms, trifluoromethyl, carboxy, thiocyano, methylthio, methylsulfinyl, methylsulfonyl, methylsulfonimidoyl or methylsulfonamido with the proviso that two or three of the groups R.sub.2 through R.sub.5 are hydrogen; or a salt thereof with a physiologically acceptable acid or base;possess valuable pharmacological properties.
    Type: Grant
    Filed: December 22, 1982
    Date of Patent: July 3, 1984
    Assignee: Schering, Aktiengesellschaft
    Inventors: Helmut Biere, Joachim-Friedrich Kapp, Irmgard Bottcher
  • Patent number: 4440776
    Abstract: Imidazole derivatives of the formula ##STR1## wherein Ar.sub.1 and Ar.sub.2 are each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that Ar.sub.1 and Ar.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is a C.sub.2-6 -alkyl or -alkenyl residue substituted by one or two of hydroxy, C.sub.1-4 alkoxy, C.sub.2-8 alkylenedioxy, C.sub.1-6 alkanoyloxy or benzoyloxy, or by one alkoxycarbonyl group;and the salts thereof with physiologically acceptable acids, possess valuable pharmacological properties.
    Type: Grant
    Filed: March 24, 1982
    Date of Patent: April 3, 1984
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Irmgard Bottcher
  • Patent number: 4402960
    Abstract: Imidazole derivatives of the formula ##STR1## wherein AR.sub.1 and AR.sub.2 each independently is phenyl, optionally substituted by halogen atoms, alkyl residues, alkoxy residues; or dialkylamino residues; pyridyl, furyl; or thienyl;R.sub.1 is hydrogen; alkyl of 1-6 carbon atoms optionally substituted by hydroxy groups, alkoxy groups, or acyloxy groups; benzyl; tetrahydropyran-2-yl; or tetrahydrofuran-2-yl;n is 0, 1 or 2; andZ is phenyl optionally substituted by halogen atoms, alkyl groups, alkoxy groups, nitro groups, amino, acylamino groups or trifluoromethyl groups; pyridyl; N-oxypyridyl; pyrimidinyl; thiazolyl; or thienyl, and the physiologically acceptable salts thereof with acids,have valuable pharmacological activity, e.g., antiinflammatory activity.
    Type: Grant
    Filed: July 2, 1981
    Date of Patent: September 6, 1983
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Irmgard Bottcher
  • Patent number: 4355039
    Abstract: Imidazole derivatives of the formula ##STR1## wherein Ar.sub.1 and Ar.sub.2 are each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that Ar.sub.1 and Ar.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is a C.sub.2-6 -alkyl or -alkenyl residue substituted by one or two of hydroxy, C.sub.1-4 alkoxy, C.sub.2-8 alkylenedioxy, C.sub.1-6 alkanoyloxy or benzoyloxy, or by one alkoxycarbonyl group;and the salts thereof with physiologically acceptable acids, possess valuable pharmacological properties.
    Type: Grant
    Filed: September 24, 1980
    Date of Patent: October 19, 1982
    Assignee: Schering, Aktiengesellschaft
    Inventors: Ulrich Niedballa, Irmgard Bottcher
  • Patent number: 4289777
    Abstract: Quinolonecarboxylic acid derivatives of the formula ##STR1## wherein the grouping ##STR2## is independently in the 6-, 7- or 8-position of each of the quinolone residues;m and n independently are each 1-4;R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms;R.sub.2 is hyrogen, alkanoyl of 1-8 carbon atoms or benzoyl; andX is hydrogen, alkyl of 1-6 carbon atoms or the cation of a base which produces a physiologically acceptable salt with the quinolonecarboxylic acid,have valuable pharmacological properties.
    Type: Grant
    Filed: December 27, 1979
    Date of Patent: September 15, 1981
    Assignee: Schering, Aktiengesellschaft
    Inventors: Rudolf Albrecht, Eberhard Schroder, Irmgard Bottcher
  • Patent number: 4272543
    Abstract: Imidazole derivatives of the formula ##STR1## wherein AR.sub.1 and AR.sub.2 are independently each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that AR.sub.1 and AR.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is cyano; alkynyl of 2-6 carbon atoms; cycloalkyl of 3-8 carbon atoms; cycloalkyl of 3-8 carbon atoms substituted by hydroxy, acyloxy, hydroxymethyl or acyloxymethyl, "acyl" in both cases being the acyl group of a hydrocarbon, aliphatic C.sub.1-6 carboxylic acid or of benzoic acid; or alkyl of 1-4 carbon atoms substituted by cyano, phenyl or cycloalkyl of 3-6 carbon atoms;or physiologically acceptable salts thereof with an acid, have valuable pharmacological properties.
    Type: Grant
    Filed: December 27, 1979
    Date of Patent: June 9, 1981
    Assignee: Schering, Aktiengesellschaft
    Inventors: Ulrich Niedballa, Irmgard Bottcher
  • Patent number: 4269847
    Abstract: Imidazole derivatives of the formula ##STR1## wherein Ar.sub.1 and Ar.sub.2 are each phenyl; phenyl substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-6 dialkylamino; pyridyl; furyl; or thienyl; with the proviso that Ar.sub.1 and Ar.sub.2 are not both unsubstituted phenyl;R.sub.1 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by hydroxy, C.sub.1-4 alkoxy or C.sub.1-6 alkanoyloxy;n is 0, 1 or 2; andZ is a C.sub.2-6 -alkyl or -alkenyl residue substituted by one or two of hydroxy, C.sub.1-4 alkoxy, C.sub.2-8 alkylenedioxy, C.sub.1-6 alkanoyloxy or benzoyloxy, or by one alkoxycarbonyl group;and the salts thereof with physiologically acceptable acids, possess valuable pharmacological properties.
    Type: Grant
    Filed: May 22, 1979
    Date of Patent: May 26, 1981
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Irmgard Bottcher
  • Patent number: 4244960
    Abstract: Indanyl derivatives of the formula ##STR1## wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R.sub.1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by fluorine or chlorine; A is ##STR2## Y is oxo, oximino, C.sub.1-4 -alkoximino of 1-4 carbon atoms, phenylhydrazono or p-toluenesulfonylhydrazono; n is 0, 1 or 2; R.sub.2 is alkyl of 1-4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl of 1-4 carbon atoms, nitro or carboxy; Z is hydroxy, acyloxy of 1 to 6 carbon atoms, R.sub.1 SO.sub.3 -- amino, acylamino of 1 to 6 carbon atoms, R.sub.1 SO.sub.2 NH-- or cyano, and V is hydrogen, acyl of 1 to 6 carbon atoms or R.sub.1 SO.sub.2 --, and the salts thereof with physiologically acceptable bases or acids have valuable pharmacological and herbicidal activity.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: January 13, 1981
    Assignee: Schering, Aktiengesellschaft
    Inventors: Eberhard Schroder, Clemens Rufer, Irmgard Bottcher, Joachim-Friedrich Kapp