Abstract: Embodiments of various aspects described herein are directed to methods, systems, and kits for identifying a functional or physiological state of a target cell. The inventions described herein are based on a novel approach that combines biochemical expression measurements of a sample (e.g., gene expression data) with mapping of the measurements onto a graphical representation of a plurality of reference points (loci). Each reference point corresponds to a reference sample with a known phenotype and reflects interrelationships between multi-dimensional biochemical expression measurements of the reference samples. By locating the sample relative to reference points on the graphical representation, the physiological or functional state of the sample can be identified. The methods, systems and kits described herein can be used for various applications, including, e.g., but not limited to, determining an effect of a perturbagen on a target cell, molecule screening, and diagnosis and/or treatment of a subject.

Abstract: Changes in association between a genetic variant and a disorder can be used as a prompt to automatically revise the diagnosis based on the patient's genetic information. For example, revisions in levels of confidence of a curated database of variants can trigger sending an updated report to the clinician or patient.

Abstract: A cable that allows a host device to selectively access and communicate with an associated peripheral device by establishing a data communication pathway therebetween. The host device is typically of the type arranged for generating an identifier signal designating a selected peripheral device. The cable includes one or more controllers responsive to the identifier signal designating the associated peripheral device, and establishes a communication pathway between the host device and the selected peripheral device in response to the appropriate identifier signal. The cable further includes a transceiver and a voltage regulator. The transceiver transforms the data signals into a transformed signal having a selected protocol compatible with at least the host device, e.g., RS-232 compatible signals. The voltage regulator supplies operating power to the cable.