Abstract: The present disclosure relates to a breathable layered flexible material comprising at least one polyvinyl chloride (PVC) porous layer or a plurality of PVC porous layers and a support layer. The the pores of the PVC porous layer or plurality of PVC porous layers are obtainable by water evaporation of a water-in-oil PVC emulsion. The pores extend from the PVC layer to the support layer providing the material breathability. The disclosure also relates to a method for preparing the breathable layered flexible material. Upholsteries, in particular car upholsteries, comprising the breathable layered flexible material are also disclosed.

Abstract: The present disclosure relates to nitenin analogue compounds (of formulas I, II, III and IV) and their use as pharmaceutical agent in the treatment, prevention or reduction of both acute and chronic pain. The mode of action disclosed herein allows nitenin and nitenin analogue compounds to act as analgesic through reduction of K30 currents rather than their potentiation. Related to their high efficacy in the treatment of pain, these compounds are highly selective for slow voltage-activated potassium (K30 ) currents expressed in the small diameter dorsal root neurons (sDRGns), mainly on those mediated by the voltage-dependent potassium channel (KV), KV1.3. Such findings, together with those showing that nitenin and nitenin analogue compounds act as activity dependent blockers also lead to very reduced side-effects.

Abstract: The present patent application relates to the use of antagonists of delayed rectifier potassium (K+) channels, more specifically Kv1.3 antagonists, as pharmaceutical agents in the treatment, prevention or reduction of both acute and chronic pain. The results and mode of action disclosed herein describe how Kv1.3 antagonists may act as analgesics through reduction of K+ currents rather than their potentiation. With regard to their high efficacy in the treatment of pain, these compounds are highly selective for slow delayed rectifier voltage-activated potassium (K+) currents. Such findings, together with those showing that nitenin, PSORA-4, PAP-1 and AM92016 hydrochloride act as K+ channel blockers and by their effects on K+ current inactivation profiles, also translate into an analgesic effect with reduced side effects. The results disclosed herein show that compounds that inhibit delayed rectifying Kv1.

Abstract: Some implementations can include a computer-implemented method and/or system for medical gas inspection and electronic inspection report generation.

Abstract: A composition for deodorizing and refreshing surfaces such as carpets, upholstery, furniture etc. The composition disclosed is a highly friable foam that rapidly evaporates upon contact with the surface to be refreshed. Therefore, the composition does not require removal by vacuuming after application to the surface. A method for using the composition to deodorize and refresh a surface is also disclosed.