Abstract: A device for delivering metered aerosols g an active ingredient in solution in a propellant consisting of a hydrofluoroalkane (HFA), selected from 1,1,1,2-tetrafluoroethane (HFA 134a), 1,1,1,2,3,3,3-heptafluoropropane (HFA 227) or mixtures thereof, a co-solvent such as ethanol and optionally a low-volatility component preferably selected from glycerol, propylene glycol polyethylene glycol, oleic acid and isopropyl myristate, said device comprising a flat body with a seat for housing the can, an inhalation mouthpiece and an expansion chamber shaped to create a vortex flow of the aerosol particles expelled by the actuator, wherein the actuator orifice diameter is in the range between 0.30 and 0.50 mm.

Abstract: An inhaler for the local administration of powdered drugs to the respiratory tract. The inhaler includes a nozzle and a main body which itself defines a storage chamber for the medicinal substance, a dosing mechanism which supplies precisely measured doses of the drug and a dispensing system which pours the dose of the drug delivered into a collecting chamber. A cavity of the nozzle communicates with the collecting chamber through a central channel designed to reduce air flow resistance as much as possible. Lateral holes provided in the body of the inhaler allow for the passage of air from the outside. Upon inhalation, a negative pressure is created in the chamber in which the dose of powder delivered is collected, drawing an air inflow from the outside. The air flow is mixed with the medicinal substance particles and through the central channel, enters the cavity of the nozzle from where it is directly inhaled.

Abstract: A device for mouth-inhaling medicaments dispensed as aerosols by pressurized cans. The device is flat and compact in shape, and includes a seat for housing a can and defines an expansion chamber into which the aerosol dispensed by the can, when operated, penetrates and expands to circulate with a vortex flow which causes the solvent to evaporate and the flow movement to continue for a relatively long time, hence enabling only very small particles of the medicament to be drawn into the bronchial tubes and lungs. There is only minimum aerosol particle deposition on the walls of the oropharingeal cavity, and inhalation can continue after the entry of aerosol into the expansion chamber ceases.