Patents by Inventor Isao Hayakawa
Isao Hayakawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160257651Abstract: A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.Type: ApplicationFiled: April 18, 2014Publication date: September 8, 2016Applicant: JUNTENDO EDUCATIONAL FOUNDATIONInventors: Keiichi HIRAMATSU, Yuh MORIMOTO, Tadashi BABA, Isao HAYAKAWA
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Patent number: 8455482Abstract: A quinolone antibacterial compound, or a salt or hydrate of the compound, for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g.Type: GrantFiled: March 11, 2011Date of Patent: June 4, 2013Assignee: Daiichi Sankyo Company, LimitedInventors: Hisashi Takahashi, Junichi Kuroyanagi, Rie Miyauchi, Masatoshi Nagamochi, Makoto Takemura, Isao Hayakawa
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Patent number: 8078306Abstract: An apparatus polishes an object material such as a film on a substrate. This apparatus includes a polishing table for holding a polishing pad having a polishing surface, a motor configured to drive the polishing table, a holding mechanism configured to hold a substrate having an object material to be polished and to press the substrate against the polishing surface, a dresser configured to dress the polishing surface, and a monitoring unit configured to monitor a removal amount of the object material. The monitoring unit is operable to calculate the removal amount of the object material using a model equation containing a variable representing an integrated value of a torque current of the motor when polishing the object material and a variable representing a cumulative operating time of the dresser.Type: GrantFiled: October 29, 2008Date of Patent: December 13, 2011Assignees: Ebara Corporation, Kabushiki Kaisha ToshibaInventors: Hidetaka Nakao, Eisaku Hayashi, Kunio Oishi, Isao Hayakawa, Yoshiaki Miyake, Yoshikuni Tateyama, Takeshi Ashihara
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Patent number: 7977327Abstract: A quinolone antibacterial compound, or a salt or hydrate of the compound, for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g.Type: GrantFiled: May 13, 2005Date of Patent: July 12, 2011Assignee: Daiichi Sankyo Company, LimitedInventors: Hisashi Takahashi, Junichi Kuroyanagi, Rie Miyauchi, Masatoshi Nagamochi, Makoto Takemura, Isao Hayakawa
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Publication number: 20110166131Abstract: A quinolone antibacterial compound, or a salt or hydrate of the compound, for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g.Type: ApplicationFiled: March 11, 2011Publication date: July 7, 2011Applicant: DAIICHI PHARMACEUTICAL CO., LTD.Inventors: Hisashi TAKAHASHI, Junichi Kuroyanagi, Rie Miyauchi, Masatoshi Nagamochi, Makoto Takemura, Isao Hayakawa
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Patent number: 7902226Abstract: 3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substituents as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE. Thus these compounds are usable as drugs.Type: GrantFiled: December 26, 2006Date of Patent: March 8, 2011Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Hisashi Takahashi, Rie Miyauchi, Masao Itoh, Makoto Takemura, Isao Hayakawa
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Publication number: 20090111358Abstract: The present invention provides a apparatus for polishing an object material such as a film on a substrate. This apparatus includes a polishing table for holding a polishing pad having a polishing surface, a motor configured to drive the polishing table, a holding mechanism configured to hold a substrate having an object material to be polished and to press the substrate against the polishing surface, a dresser configured to dress the polishing surface, and a monitoring unit configured to monitor a removal amount of the object material. The monitoring unit is operable to calculate the removal amount of the object material using a model equation containing a variable representing an integrated value of a torque current of the motor when polishing the object material and a variable representing a cumulative operating time of the dresser.Type: ApplicationFiled: October 29, 2008Publication date: April 30, 2009Inventors: Hidetaka Nakao, Eisaku Hayashi, Kunio Oishi, Isao Hayakawa, Yoshiaki Miyake, Yoshikuni Tateyama, Takeshi Ashihara
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Publication number: 20080045520Abstract: The present invention contemplates provision of a quinolone antibacterial agent and a drug for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g., convulsion), and which exhibit higher safety. A compound represented by the following formula (I): a salt of the compound, or a hydrate of the compound or the salt; and an antibacterial drug and an infectious disease treating drug containing the compound as an active ingredient.Type: ApplicationFiled: May 13, 2005Publication date: February 21, 2008Applicant: Daiichi Pharmaceutical Co., LTD.Inventors: Hisashi Takahashi, Junichi Kuroyanagi, Rie Miyauchi, Masatoshi Nagamochi, Makoto Takemura, Isao Hayakawa
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Publication number: 20070123560Abstract: 3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substituents as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE. Thus these compounds are usable as drugs.Type: ApplicationFiled: December 26, 2006Publication date: May 31, 2007Inventors: Hisashi Takahashi, Rie Miyauchi, Masao Itoh, Makoto Takemura, Isao Hayakawa
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Patent number: 6900225Abstract: (?)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R, 2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid.1HCl.1H2O and antibacterial compositions containing this compound. The compound of the present invention exhibits not only excellent antibacterial activity and safety, but also remarkable stability against light and humidity, and is thus useful as an antibacterial agent.Type: GrantFiled: March 30, 2001Date of Patent: May 31, 2005Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Masao Itoh, Tetsuya Suzuki, Tsuyoshi Ohtani, Masayasu Sekiguchi, Rie Miyauchi, Isao Hayakawa
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Publication number: 20040142957Abstract: (−)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R, 2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid.1HCl.1H2O and antibacterial compositions containing this compound. The compound of the present invention exhibits not only excellent antibacterial activity and safety, but also remarkable stability against light and humidity, and is thus useful as an antibacterial agent.Type: ApplicationFiled: January 9, 2004Publication date: July 22, 2004Applicant: DAIICHI PHARMACEUTICAL CO., LTD.Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Masao Itoh, Tetsuya Suzuki, Tsuyoshi Ohtani, Masayasu Sekiguchi, Rie Miyauchi, Isao Hayakawa
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Publication number: 20040097515Abstract: An antimicrobial drug containing a compound represented by the following formula (I): 1Type: ApplicationFiled: September 26, 2003Publication date: May 20, 2004Inventors: Hisashi Takahashi, Takehiro Hagiwara, Isao Hayakawa
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Publication number: 20040063754Abstract: 3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substitunets as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE. Thus these compounds are usable as drugs.Type: ApplicationFiled: May 19, 2003Publication date: April 1, 2004Inventors: Hisashi Takahashi, Rie Miyauchi, Masao Itoh, Makoto Takemura, Isao Hayakawa
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Publication number: 20030187008Abstract: (−)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R, 2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid.1HCl.1H2O and antibacterial compositions containing this compound. The compound of the present invention exhibits not only excellent antibacterial activity and safety, but also remarkable stability against light and humidity, and is thus useful as an antibacterial agent.Type: ApplicationFiled: March 31, 2003Publication date: October 2, 2003Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Masao Itoh, Tetsuya Suzuki, Tsuyoshi Ohtani, Masayasu Sekiguchi, Rie Miyauchi, Isao Hayakawa
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Patent number: 6573260Abstract: This invention provides a quinolone derivative which exerts strong antibacterial action upon various bacteria and has high safety, and it relates to a compound having a structure of formula (I), its salts and hydrates thereof: {R1 and R2: hydrogen, alkyl; n: 1 to 4; Q: following structure (Ia): [R3: alkyl, alkenyl, halogenoalkyl, cyclic alkyl, aryl, heteroaryl, alkoxyl, alkylamino; R4: hydrogen, alkylthio; R5: hydrogen, amino, hydroxyl, thiol, halogenomethyl, alkyl, alkenyl, alkynyl, alkoxyl; X1: halogen, hydrogen, A1: nitrogen, structure of formula (II): (X2: hydrogen, amino, halogen, cyano, halogenomethyl, halogenomethyl, alkyl, alkenyl, alkynyl, alkoxyl; R4 and R3 or X2 and R3 may together form a cyclic structure; Y: hydrogen, various ester forming groups]}.Type: GrantFiled: May 24, 2001Date of Patent: June 3, 2003Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Makoto Takemura, Hisashi Takahashi, Rie Miyauchi, Toshiyuki Takeda, Isao Hayakawa
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Patent number: 6031102Abstract: N.sub.1 -(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed: ##STR1## These compounds have patent antibacterial activities against a wide variety of infectious bacteria and are useful as antibacterial agents by oral or parenteral administration.Type: GrantFiled: April 6, 1998Date of Patent: February 29, 2000Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Isao Hayakawa, Youichi Kimura
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Patent number: 5767127Abstract: N.sub.1 -(1,2-cis-2-halogenocydopropyl)-substituted pyridonecarboxylic acid derivatives represented by formula (I) and the salts thereof are disclosed. These compounds have patent antibacterial activities against a wide variety of infectious bacteria, and are useful as antibacterial agents by oral or parenteral administration.Type: GrantFiled: June 7, 1995Date of Patent: June 16, 1998Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Isao Hayakawa, Youichi Kimura
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Patent number: 5696132Abstract: Quinolone derivatives are known as synthetic antimicrobial agents having a condensed pyridonecarboxylic acid skeleton, and those having substituents on various replaceable positions of said skeleton are known. In particular, if diastereomers exist, there are 4 or more kinds of stereoisomers. A mixture of diastereomers is a mixture of isomers having different physical properties and is difficult to apply as a drug as such. The present invention provides an antimicrobial 1-(1,2-cis-2-fluorocyclopropyl)-substituted quinolone derivative represented by formula I shown below which, although involving diastereomers, consists of a single stereoisomer. ##STR1## wherein R.sup.1 represents a methyl group, a difluoromethyl group, etc.; R.sup.2 represents a saturated nitrogen-containing heterocyclic group; A represents C--X.sup.3 or a nitrogen atom; X.sup.1 and X.sup.2 each represents a halogen atom; and X.sup.3 and Z represent a hydrogen atom, etc.Type: GrantFiled: January 26, 1994Date of Patent: December 9, 1997Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Isao Hayakawa, Youichi Kimura, Hisashi Takahashi
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Patent number: 5587386Abstract: N.sub.1 -(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed: ##STR1## These compounds have patent antibacterial activities against a wide variety of infectious bacteria and are useful as antibacterial agents by oral or parenteral administration.Type: GrantFiled: October 28, 1993Date of Patent: December 24, 1996Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Isao Hayakawa, Youichi Kimura
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Patent number: RE41149Abstract: N1-(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed: These compounds have patent antibacterial activities against a wide variety of infectious bacteria and are useful as antibacterial agents by oral or parenteral administration.Type: GrantFiled: June 3, 2004Date of Patent: February 23, 2010Assignee: Daiichi Sankyo Company, LimitedInventors: Isao Hayakawa, Youichi Kimura