Abstract: The active support substance and the adsorbent for chromatography, which have got all of the properties desired for affinity chromatography, can be constituted by a porous copolymer comprising gel copolymer which is principally composed of (A) a glycidyl monovinylester or glycidyl monovinylether and (B) alkyleneglycol divinylester, and combination groups to be bound to ligands through a covalent bond, the (A) component being crosslinked by the (B) component, and the combination groups being bound to epoxy groups of the (A) component.

Abstract: Spherical porous fine particles of a cross-linked polymer can be obtained in the continuous phase by subjecting a mixture of a monovinyl aromatic compound and a polyvinyl aromatic compound to aqueous suspension polymerization in the presence of a paraffin wax with use of an initiator. This product is very suitable as a filler for gel permeation chromatography. Ion exchange groups can be introduced into the obtained polymer and a column filler suitable for ion exchange chromatography of amino acids, substances related to nucleic acids, proteins and the like is thus obtained.