Patents by Inventor Isao Karube

Isao Karube has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090257917
    Abstract: It is intended to provide a sensor chip which has a small size and is easily produced and capable of determining quantities of at least two components of multiple samples rapidly, conveniently, and correctly as well as to provide a production method capable of producing the sensor chip easily and with high productivity. A sensor chip includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, multiple reaction portions disposed between the substrate and the cover layer, multiple detection units exposed in the hollow reaction portions, and a sample inlet communicated with the hollow reaction portions and a method for producing the sensor chip.
    Type: Application
    Filed: October 16, 2006
    Publication date: October 15, 2009
    Inventors: Hideaki Nakamura, Masao Gotoh, Tomoko Ishikawa, Isao Karube, Toshifumi Hosoya, Shingo Kaimori, Moriyasu Ichino
  • Publication number: 20090152127
    Abstract: Provided are a biosensor chip measurement machine that can obtain accurate measurement results within a short period of time by employing only a tiny amount as a sample, and a measurement method therefor. A biosensor measurement machine 20 includes a power source 21, which is connected to a voltage regulator 22, a measurement instrument 23, and a controller 24 for supplying power. When a biosensor chip 1 is connected to the biosensor measurement machine 20 and a voltage is applied, the measurement instrument begins the measurement of a current value for a biosensor. When a measured current value or a measured charge value is greater than a reference value, the measurement is ended in accordance with an instruction issued by the controller 24, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.
    Type: Application
    Filed: September 8, 2006
    Publication date: June 18, 2009
    Applicants: SUMITOMO ELECTRIC INDUSTRIES, LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE
    Inventors: Shingo Kaimori, Toshifumi Hosoya, Moriyasu Ichino, Takahiko Kitamura, Isao Karube, Masao Gotoh, Hideaki Nakamura, Tomoko Ishikawa
  • Publication number: 20090124876
    Abstract: There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein the puncture needle is able to be kept hygienic without the need of a protective cover or the like for the puncture needle. There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein a soft material is attached to the front end of the puncture needle so that the front end of the puncture needle is protected.
    Type: Application
    Filed: June 27, 2006
    Publication date: May 14, 2009
    Inventors: Hideaki Nakamura, Masao Gotoh, Isao Karube
  • Publication number: 20090123335
    Abstract: It is intended to provide a sensor chip that enables detection of a deterioration state of a reagent applied on a reaction portion when measuring a concentration of a measurement object substance and a sensor system that enables a correct measurement by using the sensor chip for detecting the reagent deterioration state. A sensor chip including two substrates opposed to each other, a spacer layer sandwiched between the substrates, a multiple reaction portions provided in the spacer layer, and detection electrode units disposed on surfaces of the substrates facing to the spacer layer and exposed to the reaction portions, wherein an identical reagent A is applied on two or more of the reaction portions, and another reagent B that reacts with the reagent A is applied on at least one of the two reaction portions and a sensor system including the sensor chip and a measurement unit for comparing current values from the two or more reaction portions on which the identical reagent A is applied.
    Type: Application
    Filed: October 25, 2006
    Publication date: May 14, 2009
    Inventors: Hideaki Nakamura, Masao Gotoh, Tomoko Ishikawa, Isao Karube, Toshifumi Hosoya, Shingo Kaimori, Moriyasu Ichino
  • Publication number: 20090093695
    Abstract: There is provided a biosensor (which is integrated with a needle) with a high precision where an assembling is easy and reproducibility of the prepared biosensor (integrated with a needle) is good. There is provided with a biosensor comprising: two sheets of electrically insulating substrates connected by a connecting part, and an electrode and a spacer formed on one of or both of the two sheets of electrically insulating substrates, wherein the two sheets of the electrically insulating substrates are folded along the connecting part, and the electrode and the spacer are positioned between the electrically insulating substrates.
    Type: Application
    Filed: June 27, 2006
    Publication date: April 9, 2009
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventors: Hideaki Nakamura, Masao Gotoh, Isao Karube
  • Patent number: 7514002
    Abstract: A method for removing phosphorus is provided in which eutrophic water as a treatment target is supplied to fly ash thereby removing phosphorus contained in the eutrophic water. The fly ash includes about 3% or more calcium oxide as a component. Alternatively, the fly ash consists of a double-structure embedding fine particles in a cavity of a hollow-particle structure having a hole in a part of the surface. Alternatively, the fly ash includes about 3% or more calcium oxide as a component and consisting of a double structure embedding fine particles in a cavity of a hollow-particle structure having a hole in a part of the surface.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: April 7, 2009
    Assignee: Hokuriku Electric Power Company
    Inventors: Keiichi Betsumori, Takashi Matsubara, Hiroshi Saiki, Isao Karube
  • Publication number: 20090050986
    Abstract: A method for fabricating a sensor chip having a substrate, a cover layer, a spacer layer interposed between the substrate and the cover layer, and a hollow reaction section provided in the spacer layer, the method comprising the steps of: affixing two or more adhesive or bonding tapes onto a sheet where a plurality of substrates are to be formed or onto a plurality of substrates, to thus form a spacer layer; and forming a hollow reaction section from one or a plurality of gaps between the tapes, whereby volumetric variations or positional displacements of the hollow reaction section can be reduced. A sensor chip which can be fabricated by this method.
    Type: Application
    Filed: January 23, 2006
    Publication date: February 26, 2009
    Inventors: Shingo Kaimori, Toshifumi Hosoya, Moriyasu Ichino, Hideaki Nakamura, Masao Gotoh, Fumiyo Kurusu, Tomoko Ishikawa, Isao Karube
  • Publication number: 20090053105
    Abstract: There is provided a sensor chip including: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer, in which a reaction is performed between a sample and a reagent applied thereinto; a sensing member constructed of an electrode which is exposed to the hollow reaction portion; and a sample inlet for conducting the sample to the hollow reaction portion, wherein entire portions of the base plate and the cover layer, which are located opposite to the sensing member provided with the hollow reaction portion, are made transparent.
    Type: Application
    Filed: January 23, 2006
    Publication date: February 26, 2009
    Inventors: Toshifumi Hosoya, Shingo Kaimori, Moriyasu Ichino, Hideaki Nakamura, Masao Gotoh, Fumiyo Kurusu, Tomoko Ishikawa, Isao Karube
  • Publication number: 20090020420
    Abstract: It is intended to provide a biosensor chip capable of rapid and correct measurement, including a reaction chamber that enables a measurement of a very small amount of a measurement sample and has a small capacity and potassium ferricyanide having a very small crystal particle size disposed in the reaction chamber. In a biosensor chip 1, electrodes 3 and 4 are disposed on the lower substrate 2, and lower spacer 5 (7 and 8) is adhered on the electrodes 3 and 4. An upper spacer 11 (12 and 13) is adhered to an upper substrate 15, and a lower spacer 5 is attached to the upper spacer 11 by and adhesive agent 10. A lower groove 9 is formed between long and short lower spacers 7 and 8, and an upper groove 14 is formed between long and short spacers 12 and 13, so that a reaction chamber 17 is formed by the upper and lower grooves 9 and 14. A capacity of the reaction chamber is 0.
    Type: Application
    Filed: October 16, 2006
    Publication date: January 22, 2009
    Applicant: SUMITOMO ELECTRIC INDUSTRIES., LTD.
    Inventors: Takahiko Kitamura, Toshifumi Hosoya, Shingo Kaimori, Moriyasu Ichino, Hideaki Nakamura, Isao Karube, Masao Gotoh, Tomoko Ishikawa
  • Publication number: 20080267292
    Abstract: The present invention relates to a method of and an apparatus for recording motion picture with higher compression efficiency. The method comprising the steps of: performing block-based motion search for an input picture to calculate a motion vector of each block; setting up blocks having a similar motion vector as a similar motion area, the similar motion vector included in calculated motion vectors; calculating a representative motion vector by use of a motion vector provided by each block included in the set similar motion area; selecting which of the calculated representative motion vector or the motion vector provided by each block is to be used, for each block; and generating encoded data by use of the motion vector selected based on the result of the selection and a prediction picture of each block generated using the motion vector.
    Type: Application
    Filed: April 23, 2008
    Publication date: October 30, 2008
    Inventors: Hiroaki ITO, Tomokazu Murakami, Isao Karube, Masashi Takahashi, Yuto Komatasu
  • Publication number: 20080248457
    Abstract: Provided are a sensor chip and a manufacturing method of this sensor chip, that includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, and a hollow reaction section between the substrate and the cover layer, wherein warping due to changes in the environmental temperature and humidity does not occur. A sensor chip is provided including: a substrate; a cover layer; a spacer layer sandwiched between the substrate and the cover layer; a hollow reaction section provided between the substrate and the cover layer; and a detection section provided in the hollow reaction section, wherein the substrate and the cover layer are made of the same material and have the same thickness, and a material and a shape of the spacer layer are symmetrical with respect to a plane which is parallel to the substrate and located at equal distances from the substrate and from the cover layer, and a manufacturing method of the sensor chip is provided.
    Type: Application
    Filed: June 21, 2005
    Publication date: October 9, 2008
    Inventors: Toshifumi Hosoya, Shingo Kaimori, Moriyasu Ichino, Isao Karube, Masao Gotoh, Hideaki Nakamura, Fumiyo Kurusu, Tomoko Ishikawa
  • Publication number: 20080220517
    Abstract: A technique for controlling membrane denaturation reactions other than physical shear force was developed. For example, the present invention provides, a method for causing membrane disruption at a specific site by reacting a stimulus such as light with a compound that is activated by the stimulus, where the reaction occurs on a membrane such as a biomembrane. It also provides a membrane structure such as cells in which a specific site has been disrupted, which are obtained by the present method. Introduction of substances such as genes also became possible by using this membrane structure. Further provided is a membrane-destroying member for disrupting a membrane at a specific site. Thus, the present invention enabled, for example, easy membrane penetration using components constituting microelectrodes, micromanipulators, and microinjectors, which were conventionally hardly usable in penetrating cell membranes.
    Type: Application
    Filed: August 28, 2007
    Publication date: September 11, 2008
    Applicant: TOUDAI TLO, LTD.
    Inventors: Isao Karube, Takashi Saitoh
  • Publication number: 20080194988
    Abstract: There is provided a biosensor unified with a needle in which, since its constitution is simple, its assembling is easy in spite of having strength, collecting of body fluid sample can be conducted surely without waste, a puncturing needle is not polluted by a reagent layer, carrying is easy due to its simple package and hygiene can be maintained even after use. There is also provided a biosensor unified with a needle in which an assembling is easy without deteriorating its strength and collecting a body fluid sample can be surely conducted without waste where a puncturing needle is not polluted with a reagent layer.
    Type: Application
    Filed: March 1, 2006
    Publication date: August 14, 2008
    Applicant: National Institute Of Advanced Industrial Science And Technology
    Inventors: Hideaki Nakamura, Masao Gotoh, Isao Karube
  • Publication number: 20080129280
    Abstract: A coupled member made of a plurality of sensor chips is featured by that adjacent sensor chips are coupled to each other under cuttable condition; the respective sensor chips can be cut and piece-separated from the coupled member in a higher efficiency; and even after the sensor chips are piece-separated, these sensor chips can be readily and quickly stored in containers thereof; and furthermore, the sensor chips can be easily checked and failure chips can be readily removed.
    Type: Application
    Filed: January 23, 2006
    Publication date: June 5, 2008
    Inventors: Shingo Kaimori, Toshifumi Hosoya, Moriyasu Ichino, Hideaki Nakamura, Masao Gotoh, Fumiyo Kurusu, Tomoko Ishikawa, Isao Karube
  • Publication number: 20080112486
    Abstract: The calculation processing amount of encoding processing is reduced while suppressing a decrease in encoding efficiency. An encoding method includes the steps of generating predicted image data from an image of a predetermined reference frame; generating differential image data from a difference between the predicted image data and image data of one frame of the input image data; performing discrete cosine transformation processing and quantization processing for the differential image data for generating encoded image data; performing variable-length encoding processing for the encoded image data for generating an encoded stream; and performing reference frame update determination processing in which a correlation between the image of the reference frame and the image of the one frame is determined for deciding whether or not the one frame is to be used as a new reference frame.
    Type: Application
    Filed: November 8, 2007
    Publication date: May 15, 2008
    Inventors: Masashi Takahashi, Tomokazu Murakami, Hiroaki Ito, Isao Karube
  • Publication number: 20080095398
    Abstract: An object detection method which rapidly detects one or more objects existing in an image includes: a primary search step which judges whether an object exists at a predetermined interval by using a simple judgment device requiring a small number of calculation amounts; a range estimation step which estimates a range where an object actually exists from a spatial relationship obtained as a result of the primary search; a secondary search step which performs an object judgment process by using a secondary judgment device capable of performing more detailed judgment than the object judgment device used in the primary search; an object position estimation step which estimates a position where the similarity is maximum in a certain object existing range as an object existing position; and a final search step which judges a final object position.
    Type: Application
    Filed: April 25, 2007
    Publication date: April 24, 2008
    Inventors: Tomoaki Yoshinaga, Shigeki Nagaya, Isao Karube
  • Publication number: 20070286284
    Abstract: The present invention provides an image coding apparatus and an image coding method for reducing arithmetic processing while keeping a high compression ratio. A coding process necessary for the bi-prediction motion search can be effectively reduced by determining a block size for a bi-prediction motion search or a center position for a motion search on the basis of a result of a motion search of a unidirectional prediction. Further, a compression ratio can be also kept as high as possible, because the block size or the center position are obtained on the basis of the result of the motion search of the unidirectional prediction.
    Type: Application
    Filed: March 23, 2007
    Publication date: December 13, 2007
    Inventors: Hiroaki Ito, Tomokazu Murakami, Isao Karube, Taku Nakamura, Yusuke Yatabe
  • Patent number: 7303867
    Abstract: A method for detecting nucleic acids wherein the binding activity of a nucleic acid aptamer, which is formed by the hybridization of a target nucleotide sequence and a probe, is detected using the binding with a ligand as an index has been provided. Utilizing a structure such as the three-way junction, whose binding activity significantly changes depending on a mismatch of a single nucleotide, as the nucleic acid aptamer SNP can be detected.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: December 4, 2007
    Assignee: Katayanagi Institute
    Inventors: Isao Karube, Teru Kato
  • Publication number: 20070160298
    Abstract: The present invention provides a technique capable performing encoding with a high image quality and a low bit rate. An image encoder according to the present inventions includes: an image separation unit for separating a skeleton image and a texture image from an inputted image; a skeleton image encoding unit for encoding the skeleton image separated; a texture image encoding unit for encoding the texture image separated; a parameter adjustment unit for adjusting a parameter used in encoding processing of the skeleton image and the texture image; a parameter encoding unit for encoding the parameter; and a code multiplexing unit for multiplexing the skeleton image, the texture image, and the parameter which have been encoded.
    Type: Application
    Filed: July 13, 2006
    Publication date: July 12, 2007
    Inventors: Tomokazu Murakami, Hiroaki Ito, Isao Karube, Masashi Takahashi
  • Patent number: D548347
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: August 7, 2007
    Assignees: Sumitomo Electric Industries, Ltd., National Institute of Advanced Industrial Science and Technology
    Inventors: Moriyasu Ichino, Toshifumi Hosoya, Kazuhiro Kuwa, Nobuyuki Matsumura, Isao Karube, Masao Gotoh, Hideaki Nakamura, Tomoko Ishikawa