Patents by Inventor Isao Kii

Isao Kii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF SEARCHING FOR SPECIFIC-BINDING FUNCTIONAL SUBSTANCES, SPECIFIC-BINDING FUNCTIONAL SUBSTANCE SEARCH SYSTEM, SPECIFIC-BINDING FUNCTIONAL SUBSTANCE SEARCH METHOD, AND PROGRAM
    Publication number: 20240013855
    Abstract: Destabilize a protein at least partially, provide the destabilized protein in a presence of a candidate functional substance, induce its restabilization, and determine the effect of a presence of the candidate functional substance in influencing a function of the protein, in order to search for functional substances that selectively bind to a non-native state of the protein and influence the function of the protein.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 11, 2024
    Inventors: Isao KII, Gaku FURUIE, Koji UMEZAWA
  • COMPOSITION HAVING COMPOUND ACCELERATING PHOSPHORYLATION OF AMPK AS EFFECTIVE COMPONENT
    Publication number: 20180290979
    Abstract: Provided is a composition that can be used for an organ preservation solution or perfusate. Alternatively, provided is a composition for prolonging the survival of normal cells and/or a composition for inhibiting the survival of cancer cells. In one or more embodiments, a composition containing, as an active component, a compound that enhances phosphorylation of AMPK (AMP-activated protein kinase). Said composition is one that can prolong the survival of cells (especially, normal cells). Furthermore, said composition is one that can inhibit the survival of cancer cells.
    Type: Application
    Filed: April 28, 2016
    Publication date: October 11, 2018
    Applicant: Kyoto University
    Inventors: Masatoshi HAGIWARA, Masayasu TOYOMOTO, Isao KII, Takamitsu HOSOYA, Suguru YOSHIDA
  • Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor
    Patent number: 10017524
    Abstract: The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the pharmaceutical composition, or a method for preventing, improving, inhibiting the development of, and/or treating neuropsychological disorders or malignant tumors with the use of the compound and the pharmaceutical composition.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: July 10, 2018
    Assignees: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, KINOPHARMA, INC.
    Inventors: Masatoshi Hagiwara, Hiroshi Onogi, Isao Kii, Takamitsu Hosoya, Yuto Sumida
  • COMPOUND AND PHARMACEUTICAL COMPOSITION FOR NEUROPSYCHOLOGICAL DISORDER OR MALIGNANT TUMOR
    Publication number: 20170355715
    Abstract: The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the pharmaceutical composition, or a method for preventing, improving, inhibiting the development of, and/or treating neuropsychological disorders or malignant tumors with the use of the compound and the pharmaceutical composition.
    Type: Application
    Filed: July 26, 2017
    Publication date: December 14, 2017
    Applicants: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, KINOPHARMA, INC.
    Inventors: Masatoshi HAGIWARA, Hiroshi ONOGI, Isao KII, Takamitsu HOSOYA, Yuto SUMIDA
  • Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor
    Patent number: 9745323
    Abstract: The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the pharmaceutical composition, or a method for preventing, improving, inhibiting the development of, and/or treating neuropsychological disorders or malignant tumors with the use of the compound and the pharmaceutical composition.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: August 29, 2017
    Assignees: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, KINOPHARMA, INC.
    Inventors: Masatoshi Hagiwara, Hiroshi Onogi, Isao Kii, Takamitsu Hosoya, Yuto Sumida
  • Cyclic compound, method for producing cyclic compound, and method for modifying biological molecule
    Patent number: 9422294
    Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: August 23, 2016
    Assignee: JNC CORPORATION
    Inventors: Takamitsu Hosoya, Isao Kii, Suguru Yoshida, Takeshi Matsushita
  • COMPOUND AND PHARMACEUTICAL COMPOSITION FOR NEUROPSYCHOLOGICAL DISORDER OR MALIGNANT TUMOR
    Publication number: 20150225421
    Abstract: The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the pharmaceutical composition, or a method for preventing, improving, inhibiting the development of, and/or treating neuropsychological disorders or malignant tumors with the use of the compound and the pharmaceutical composition.
    Type: Application
    Filed: July 30, 2013
    Publication date: August 13, 2015
    Applicants: KYOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, KINOPHARMA, INC.
    Inventors: Masatoshi Hagiwara, Hiroshi Onogi, Isao Kii, Takamitsu Hosoya, Yuto Sumida
  • CYCLIC COMPOUND, METHOD FOR PRODUCING CYCLIC COMPOUND, AND METHOD FOR MODIFYING BIOLOGICAL MOLECULE
    Publication number: 20140364594
    Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.
    Type: Application
    Filed: July 23, 2014
    Publication date: December 11, 2014
    Inventors: Takamitsu HOSOYA, Isao KII, Suguru YOSHIDA, Takeshi MATSUSHITA
  • Cyclic compound, method for producing cyclic compound, and method for modifying biological molecule
    Patent number: 8901312
    Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: December 2, 2014
    Assignee: JNC Corporation
    Inventors: Takamitsu Hosoya, Isao Kii, Suguru Yoshida, Takeshi Matsushita
  • CYCLIC COMPOUND, METHOD FOR PRODUCING CYCLIC COMPOUND, AND METHOD FOR MODIFYING BIOLOGICAL MOLECULE
    Publication number: 20130011901
    Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.
    Type: Application
    Filed: March 9, 2011
    Publication date: January 10, 2013
    Applicant: JNC CORPORATION
    Inventors: Takamitsu Hosoya, Isao Kii, Suguru Yoshida, Takeshi Matsushita