Patents by Inventor Isao Yonekubo
Isao Yonekubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240027480Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: September 27, 2023Publication date: January 25, 2024Inventors: Susumu OSAWA, Shinya SUGIMOTO, Isao YONEKUBO
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Patent number: 11808776Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: GrantFiled: April 28, 2020Date of Patent: November 7, 2023Assignee: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11808777Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: GrantFiled: April 28, 2020Date of Patent: November 7, 2023Assignee: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11661622Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.Type: GrantFiled: June 26, 2019Date of Patent: May 30, 2023Assignee: FUJIFILM CorporationInventors: Hikaru Urano, Haruyasu Nakatsugawa, Tatsuya Ishizaka, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11442070Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are capable of performing measurement of a plurality of target components to be analyzed with high accuracies in a case where hemolysis occurs in a case of measuring an amount of target components to be analyzed in a small volume of a blood sample.Type: GrantFiled: June 27, 2019Date of Patent: September 13, 2022Assignee: FUJIFILM CorporationInventors: Kota Fukui, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11179081Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.Type: GrantFiled: June 26, 2019Date of Patent: November 23, 2021Assignee: FUJIFILM CorporationInventors: Hikaru Urano, Haruyasu Nakatsugawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11166659Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.Type: GrantFiled: June 27, 2019Date of Patent: November 9, 2021Assignee: FUJIFILM CorporationInventors: Hikaru Urano, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20200319215Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: April 28, 2020Publication date: October 8, 2020Applicant: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20200319216Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: April 28, 2020Publication date: October 8, 2020Applicant: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Patent number: 10712354Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: GrantFiled: July 6, 2015Date of Patent: July 14, 2020Assignee: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20190320961Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.Type: ApplicationFiled: June 26, 2019Publication date: October 24, 2019Applicant: FUJIFILM CorporationInventors: Hikaru URANO, Haruyasu NAKATSUGAWA, Shinya SUGIMOTO, Isao YONEKUBO
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Publication number: 20190313958Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.Type: ApplicationFiled: June 27, 2019Publication date: October 17, 2019Applicant: FUJIFILM CorporationInventors: Hikaru URANO, Shinya SUGIMOTO, Isao YONEKUBO
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Publication number: 20190317112Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are capable of performing measurement of a plurality of target components to be analyzed with high accuracies in a case where hemolysis occurs in a case of measuring an amount of target components to be analyzed in a small volume of a blood sample.Type: ApplicationFiled: June 27, 2019Publication date: October 17, 2019Applicant: FUJIFILM CorporationInventors: Kota FUKUI, Shinya SUGIMOTO, Isao YONEKUBO
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Publication number: 20190316175Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.Type: ApplicationFiled: June 26, 2019Publication date: October 17, 2019Applicant: FUJIFILM CorporationInventors: Hikaru URANO, Haruyasu NAKATSUGAWA, Tatsuya ISHIZAKA, Shinya SUGIMOTO, Isao YONEKUBO
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Patent number: 10241012Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.Type: GrantFiled: June 12, 2014Date of Patent: March 26, 2019Assignee: Leisure, Inc.Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa
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Publication number: 20170205433Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.Type: ApplicationFiled: July 6, 2015Publication date: July 20, 2017Applicant: Leisure, Inc.Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
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Publication number: 20170131189Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.Type: ApplicationFiled: June 12, 2014Publication date: May 11, 2017Applicant: Leisure, Inc.Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa