Patents by Inventor Isao Yonekubo

Isao Yonekubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240027480
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: September 27, 2023
    Publication date: January 25, 2024
    Inventors: Susumu OSAWA, Shinya SUGIMOTO, Isao YONEKUBO
  • Patent number: 11808776
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 7, 2023
    Assignee: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11808777
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 7, 2023
    Assignee: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11661622
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: May 30, 2023
    Assignee: FUJIFILM Corporation
    Inventors: Hikaru Urano, Haruyasu Nakatsugawa, Tatsuya Ishizaka, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11442070
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are capable of performing measurement of a plurality of target components to be analyzed with high accuracies in a case where hemolysis occurs in a case of measuring an amount of target components to be analyzed in a small volume of a blood sample.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: September 13, 2022
    Assignee: FUJIFILM Corporation
    Inventors: Kota Fukui, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11179081
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: November 23, 2021
    Assignee: FUJIFILM Corporation
    Inventors: Hikaru Urano, Haruyasu Nakatsugawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 11166659
    Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: November 9, 2021
    Assignee: FUJIFILM Corporation
    Inventors: Hikaru Urano, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20200319215
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: April 28, 2020
    Publication date: October 8, 2020
    Applicant: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20200319216
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: April 28, 2020
    Publication date: October 8, 2020
    Applicant: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Patent number: 10712354
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: July 14, 2020
    Assignee: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20190320961
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 24, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Hikaru URANO, Haruyasu NAKATSUGAWA, Shinya SUGIMOTO, Isao YONEKUBO
  • Publication number: 20190313958
    Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Hikaru URANO, Shinya SUGIMOTO, Isao YONEKUBO
  • Publication number: 20190317112
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are capable of performing measurement of a plurality of target components to be analyzed with high accuracies in a case where hemolysis occurs in a case of measuring an amount of target components to be analyzed in a small volume of a blood sample.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Kota FUKUI, Shinya SUGIMOTO, Isao YONEKUBO
  • Publication number: 20190316175
    Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Hikaru URANO, Haruyasu NAKATSUGAWA, Tatsuya ISHIZAKA, Shinya SUGIMOTO, Isao YONEKUBO
  • Patent number: 10241012
    Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: March 26, 2019
    Assignee: Leisure, Inc.
    Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa
  • Publication number: 20170205433
    Abstract: There is provided a method of analyzing a biological sample component that allows easy and accurate quantification and counting of any of a plasma component and a blood cell component in a trace and unknown amount of a whole blood sample collected from a finger, for example. The method of the present invention is a method of analyzing a biological sample component in a trace amount of blood, comprising analyzing a diluent buffer into which the blood has been mixed and an internal standard substance and/or an external standard substance contained in the diluent buffer, calculating a dilution ratio, and analyzing a biological component in a plasma or serum component in the blood.
    Type: Application
    Filed: July 6, 2015
    Publication date: July 20, 2017
    Applicant: Leisure, Inc.
    Inventors: Susumu Osawa, Shinya Sugimoto, Isao Yonekubo
  • Publication number: 20170131189
    Abstract: A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 ?L) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component. The present inventors found that it is possible to separate diluted plasma from diluted blood cells using a polymer gelling agent for plasma separation by means of putting a polymer gel for plasma separation in the container with a blood dilution buffer. In such case, diluted blood cells are transferred to the lower portion of the polymer gelling agent and dilute plasma is transferred to the upper portion of the same. Assay of the biological blood components using a minute amount of blood can be utilized for early detection of health status, diseases, and presymptomatic states.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 11, 2017
    Applicant: Leisure, Inc.
    Inventors: Shinya Sugimoto, Isao Yonekubo, Masato Kawaguchi, Susumu Osawa