Patents by Inventor Isis del Carmen Torrens Madrazo

Isis del Carmen Torrens Madrazo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell penetrating peptides and its use fused to biomolecules with therapeutic action
    Patent number: 8673313
    Abstract: The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: March 18, 2014
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Isis del Carmen Torrens Madrazo, Maribel Guerra Vallespi, Milaid Granadillo Rodriguez, Osvaldo Reyes Acosta, Boris Ernesto Acevedo Castro
  • Immunomodulatory and anti-tumour peptides
    Patent number: 8283324
    Abstract: The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: October 9, 2012
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Maribel Guerra Vallespi, Isis del Carmen Torréns Madrazo, Osvaldo Reyes Acosta, Hilda Elisa Garay Pérez, Gerardo Enrique Guillén Nieto, Boris Ernesto Acevedo Castro, Raimundo Ubieta Gómez
  • Streptokinase mutants
    Patent number: 6413759
    Abstract: The present invention is related to the field of biotechnology and genetic engineering techniques, particularly to a method for obtaining mutants obtain from streptokinase, to the molecules obtained from this method, as well as the expression vectors and microorganisms for recombinant obtaining. The object of the present invention is to achieve streptokinase mutants from modifications of skc-2 gene coding for streptokinase SKC-2 (Heberkinase®), such that the obtained mutants conserve their capacity for plasminogen activator complex formation having reduced antigenicity, that could constitute preferred alternatives to native streptokinase for thrombolytic therapy. The molecules obtained from present invention can be used in the treatment of disorders as myocardial infarct, pulmonary thromboembolism, surgical complications and other cases of thrombosis.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: July 2, 2002
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Isis del Carmen Torrens Madrazo, Jose de la Fuente Garcia, Ariana Garcia Ojalvo, Alina Seralena Menendez, Elder Pupo Escalona, Julio Raul Fernandez Masso, Martha de Jesus Gonzalez Griego
  • Streptokinase mutants
    Patent number: 6309873
    Abstract: The present invention is related to the field of biotechnology and genetic engineering techniques, particularly to a method for obtaining mutants obtain from streptokinase, to the molecules obtained from this method, as well as the expression vectors and microorganisms for recombinant obtaining. The object of the present invention is to achieve streptokinase mutants from modifications of skc-2 gene coding for streptokinase SKC-2 (Heberkinase®), such that the obtained mutants conserve their capacity for plasminogen activator complex formation having reduced antigenicity, that could constitute preferred alternatives to native streptokinase for thrombolytic therapy. The molecules obtained from present invention can be used in the treatment of disorders as myocardial infarct, pulmonary thromboembolism, surgical complications and other cases of thrombosis.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: October 30, 2001
    Assignee: Centro de Ingenieria Genetica y Biotechnologia
    Inventors: Isis del Carmen Torrens Madrazo, Jose de la Fuente Garcia, Ariana Garcia Ojalvo, Alina Seralena Menendez, Elder Pupo Escalona, Julio Raul Fernandez Masso, Martha de Jesus Gonzalez Griego