Patents by Inventor Israel CHARO

Israel CHARO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reducing tumor burden by administering CCR1 antagonists in combination with PD-1 inhibitors or PD-L1 inhibitors
    Patent number: 10568870
    Abstract: The present invention provides methods for reducing tumor burden, tumor growth, tumor progression, and/or metastasis in a subject suffering from a solid tumor cancer such as triple negative breast cancer. The methods include administering to a subject in need thereof a therapeutically effective amount of a PD-L1 inhibitor or a PD-1 inhibitor in combination with a small molecule chemokine receptor antagonist that blocks CCR1.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: February 25, 2020
    Assignee: ChemoCentryx, Inc.
    Inventors: Israel Charo, Heiyoun Jung, Thomas J. Schall, Penglie Zhang
  • METHODS OF TREATING PANCREATIC CANCER
    Publication number: 20190350911
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Application
    Filed: July 31, 2019
    Publication date: November 21, 2019
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • Methods of treating pancreatic cancer
    Patent number: 10398685
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: September 3, 2019
    Assignee: ChemoCentryx, Inc.
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • METHODS OF TREATING PANCREATIC CANCER
    Publication number: 20190167650
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • Method of treating pancreatic cancer
    Patent number: 10251888
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: April 9, 2019
    Assignee: ChemoCentryx, Inc.
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • Method of treating pancreatic cancer
    Patent number: 10195188
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: February 5, 2019
    Assignee: ChemoCentryx, Inc.
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • METHOD OF TREATING PANCREATIC CANCER
    Publication number: 20170368043
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Application
    Filed: September 1, 2017
    Publication date: December 28, 2017
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • METHOD OF TREATING PANCREATIC CANCER
    Publication number: 20170354657
    Abstract: The present disclosure describes methods of treating pancreatic cancer and limiting over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients comprising administering compounds and pharmaceutical combinations as described herein.
    Type: Application
    Filed: June 13, 2017
    Publication date: December 14, 2017
    Inventors: Petrus Bekker, Shichang Miao, Israel Charo, Tom Schall
  • METHOD OF TREATING LIVER FIBROSIS
    Publication number: 20170348293
    Abstract: A method of treating liver fibrosis with CCR2 antagonists is provided. The liver fibrosis may be associated with non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), emerging cirrhosis, non-cirrhotic hepatic fibrosis, type 2 diabetes mellitus (T2DM) or metabolic syndrome (MS).
    Type: Application
    Filed: June 2, 2017
    Publication date: December 7, 2017
    Inventors: Zhenhua Miao, Israel Charo
  • REDUCING TUMOR BURDEN BY ADMINISTERING CCR1 ANTAGONISTS IN COMBINATION WITH PD-1 INHIBITORS OR PD-L1 INHIBITORS
    Publication number: 20170290808
    Abstract: The present invention provides methods for reducing tumor burden, tumor growth, tumor progression, and/or metastasis in a subject suffering from a solid tumor cancer such as triple negative breast cancer. The methods include administering to a subject in need thereof a therapeutically effective amount of a PD-L1 inhibitor or a PD-1 inhibitor in combination with a small molecule chemokine receptor antagonist that blocks CCR1.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 12, 2017
    Inventors: Israel CHARO, Heiyoun JUNG, Thomas J. SCHALL, Penglie ZHANG