Abstract: The present disclosure relates to a perfusion system (300) that comprises a housing (311) containing a head unit (310), a cannister (340), a pressurization component (344), and a cannula (360). The head unit comprises an oxygenator (312) and a perfusion pump, wherein the perfusion pump may comprise a pump chamber (320) with an inlet valve (322) and an outlet valve (324), and a diaphragm (328). The system (300) can be connected to an oxygen source, such as an oxygen concentrator, and can be used to circulate perfusate fluid through a target tissue (390) or organ in the cannister to provide oxygen to the tissue. The oxygen source can provide gas to a pressure regulator, which can provide a constant gas pressure against the cannister pressurization component, which can e.g. be a diaphragm or a balloon element, in order to control and maintain cannister pressure at a preset value.

Abstract: A perfusion system includes a perfusate source and a perfusion distributor coupled to the perfusate source and configured to convey oxygen containing perfusate from the perfusate source to tissue and exhaust carbon dioxide generated by the tissue. A carbon dioxide sensor is coupled to sense the carbon dioxide generated by the tissue, which can then be used to provide a measure of tissue viability.

Abstract: The present disclosure includes a perfusion system (300) for preservation of an organ or vascular tissue outside the body, and associated methods. The system can include a first fluid reservoir (308), a second fluid reservoir (307), and a perfusion circuit. The perfusion circuit can include a first perfusion pathway to couple the first fluid reservoir to tissue (314), and a second perfusion pathway to couple the second fluid reservoir to the tissue. A first set of conditions can cause fluid contained in the first fluid reservoir to flow in a first antegrade direction from the first fluid reservoir through the tissue to the second fluid reservoir. A second set conditions can cause the perfusate fluid contained in the second fluid reservoir to flow in a second antegrade direction from the second fluid reservoir through the tissue to the first fluid reservoir.

Abstract: The present disclosure includes a system to preserve tissue and associated methods. The system can include a portable oxygen source to provide oxygen and apply a pressure gradient to a flow of the oxygen, an organ preservation system having an inlet to fluidly couple to vasculature of the tissue, and an oxygen line to fluidly couple the portable oxygen source to the organ preservation system at the inlet, wherein the portable oxygen source is to apply the pressure gradient to pump fluid containing the oxygen through the organ preservation system.

Abstract: Methods for producing crosslinked tissue matrices, crosslinked tissue matrices produced by such methods, as well as tissue products comprising such tissue matrices are disclosed. The methods comprise (1) dehydrating a collagen-containing tissue matrix to form a dehydrated collagen-containing tissue matrix; and (2) irradiating the dehydrated collagen-containing tissue matrix such that at least a portion of the dehydrated collagen-containing tissue matrix is crosslinked.

Abstract: The present disclosure provides devices for treating deep or tunneling wounds, such as fistulas. The device can include a regenerative tissue matrix that can be tailored to a variety of different wound shapes and sizes, and can be secured in place to help regenerate tissue within the wound.

Abstract: The present disclosure provides systems and methods for transfer of tissue or other materials such as adipose tissue. The systems and methods can include a vessel and a syringe to facilitate transfer of tissue between one or more vessels and tissue implantation devices.

Abstract: The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.

Abstract: Devices and methods for processing animal or human tissue are provided. The devices may include a rod having a central axis and configured to simultaneously rotate around the central axis and move along the central axis. The device can further include a group of blades which are attached to the rod and positioned proximate the rigid support surface.

Abstract: Methods for producing crosslinked tissue matrices, crosslinked tissue matrices produced by such methods, as well as tissue products comprising such tissue matrices are disclosed. The methods comprise (1) dehydrating a collagen-containing tissue matrix to form a dehydrated collagen-containing tissue matrix; and (2) irradiating the dehydrated collagen-containing tissue matrix such that at least a portion of the dehydrated collagen-containing tissue matrix is crosslinked.

Abstract: Devices, systems, and methods for tissue transfer are disclosed that can allow control of transfer speed. The devices use positive and negative pressure to advance a plunger (322) into or out of a body (311) of the device. A pressure regulator may be used to control the applied pressure. Maintaining transfer speed within acceptable ranges and/or controlling pressure or shear forces on tissues can improve the viability of certain types of tissue.

Abstract: Devices, methods of producing devices, and methods of treating an anatomic defect are provided. The devices and methods can include a flexible sheet of acellular tissue matrix and one or more elongated synthetic elements. The one or more synthetic elements may extend through the flexible sheet such that the one or more synthetic elements extend substantially parallel to a first top surface and a second bottom surface within one or more portions of the flexible sheet, and may be exposed on one or more portions of the first top surface of the device.

Abstract: The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.

Abstract: The present disclosure provides tissue products produced from adipose tissues, as well as methods for producing such tissue products. The tissue products can include acellular tissue matrices produced in multiple layers for treatment of a breast.

Abstract: The present disclosure provides systems and methods for transfer of tissue or other materials such as adipose tissue. The systems and methods can include a vessel and a syringe to facilitate transfer of tissue between one or more vessels and tissue implantation devices.

Abstract: Devices and methods for removal of animal hair are provided. The devices and methods can include one or more rotating bodies that form pinch regions for mechanical removal of animal hair.

Abstract: The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices that have been treated in select areas to increase the compressive modulus of the matrix in the selected area while maintaining the ability to support cell growth and tissue regeneration. In addition, the tissue products can include collagen-containing materials that support tissue ingrowth along with a framework of collagenous or polymeric materials such that the combination has a desired compressive or tensile modulus and/or strength while maintaining the ability to support cell growth and tissue regeneration.

Abstract: Devices and methods for removal of animal hair are provided. The devices and methods can include one or more rotating bodies that form pinch regions for mechanical removal of animal hair.

Abstract: Devices and methods for removal of animal hair are provided. The devices and methods can include one or more rotating bodies that form pinch regions for mechanical removal of animal hair.

Abstract: Devices and methods for removal of animal hair are provided. The devices and methods can include one or more rotating bodies that form pinch regions for mechanical removal of animal hair.