Patents by Inventor Istvan J. Enyedy

Istvan J. Enyedy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF BOTULINUM NEUROTOXINS
    Publication number: 20190256471
    Abstract: The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum, as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 22, 2019
    Applicant: THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AR
    Inventors: VIRGINIA I. ROXAS-DUNCAN, LEONARD A. SMITH, NIZAMETTIN GUL, JOHN H. CARDELLINA, II, REBECCA C. VIEIRA, SUSAN M. ENSEL, DAVID C.H. YANG, ISTVAN J. ENYEDY, SIVANESAN DAKSHANAMURTHY, SALIMUDDIN SHAH
  • Small molecule inhibitors of botulinum neurotoxins
    Patent number: 10301265
    Abstract: The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum, as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: May 28, 2019
    Inventors: Virginia I. Roxas-Duncan, Leonard A. Smith, Nizamettin Gul, John H. Cardellina, II, Rebecca C. Vieira, Susan M. Ensel, David C. H. Yang, Istvan J. Enyedy, Sivanesan Dakshanamurthy, Salimuddin Shah
  • SMALL MOLECULE INHIBITORS OF BOTULINUM NEUROTOXINS
    Publication number: 20110294848
    Abstract: The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum, as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 1, 2011
    Inventors: Virginia I. Roxas-Duncan, Leonard A. Smith, Nizamettin Gul, John H. Cardellina, II, Rebecca C. Vieira, Susan M. Ensel, David C.H. Yang, Istvan J. Enyedy, Sivanesan Darkshanamurthy, Salimuddin Shah
  • Small molecule inhibitors targeted at Bcl-2
    Patent number: 7354928
    Abstract: The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bind to a pocket in Bcl-2/Bcl-XL that block the anti-apoptotic function of these proteins in cancer cells and tumor tissues exhibiting Bcl-2 protein overexpression. In preferred embodiments, the small molecules of the present invention are active at the BH3 binding pocket of Bcl-2 family proteins (e.g., Bcl-2, Bcl-XL, and Mcl-1). The compositions and methods of the present invention are useful therapeutics for cancerous diseases either alone or in combination with chemotherapeutic or other drugs.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: April 8, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Dajun Yang, Istvan J. Enyedy
  • Small molecule inhibitors targeted at Bcl-2
    Patent number: 6703382
    Abstract: A method for promotion of cell death in tumor cells using tricylo-dibenzo-diazocine-dioxides that bind to a pocket of Bcl-2 and block the Bcl-2 anti-apoptotic function. A method of use of a compound of the general structural Formula (I) for use in treatment of cancer: wherein X and Y, and R and R1, and R2, R3, R4 and R5, and A and A1, have any of the values defined in the specification.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: March 9, 2004
    Assignee: Georgetown University Medical Center
    Inventors: Shaomeng Wang, Dajun Yang, Istvan J. Enyedy
  • Small molecule inhibitors targeted at Bcl-2
    Publication number: 20020137732
    Abstract: A method for promotion of cell death in tumor cells using tricylo-dibenzo-diazocine-dioxides that bind to a pocket of Bcl-2 and block the Bcl-2 anti-apoptotic function.
    Type: Application
    Filed: August 16, 2001
    Publication date: September 26, 2002
    Inventors: Shaomeng Wang, Dajun Yang, Istvan J. Enyedy