Patents by Inventor Istvan Miskolczi

Istvan Miskolczi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents
    Patent number: 8987263
    Abstract: Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C12-C24 alkyl or C10-C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: March 24, 2015
    Inventors: Meir Shinitzky, Irun R. Cohen, Raanan Margalit, Yaacov Herzig, Jeffrey Sterling, Gyorgy Toth, Istvan Miskolczi, Ferenc Rantal, Tivadar Tamas
  • Propargylated aminoindans, processes for preparation, and uses thereof
    Patent number: 8609719
    Abstract: A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: December 17, 2013
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Technion Research and Development Foundation Ltd.
    Inventors: Victor Piryatinsky, Bronka Cohen, David Lerner, Dalia Pinkert, Istvan Miskolczi, Yaacov Herzig, Hugo Gottlieb, Marta Weinstock-Rosin
  • Enantiomers of amino-phenyl-acetic acid octadec-9-(Z) enyl ester, their salts and their uses
    Patent number: 7964751
    Abstract: Disclosed are enantiomers of amino-phenyl-acetic acid octadec-9-(Z)-enyl ester, and salts thereof, including pharmaceutical compositions, uses and a process for the manufacture thereof.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: June 21, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yaacov Herzig, Jeffrey Sterling, Vladimir Ioffe, Yuriy Raizi, Istvan Miskolczi, Andras Zekany
  • PROPARGYLATED AMINOINDANS, PROCESSES FOR PREPARATION, AND USES THEREOF
    Publication number: 20100093848
    Abstract: A method for treating an individual who has been identified as having Alzheimer's disease by administering orally to the individual a therapeutically effective amount of ladostigil or a pharmaceutically active salt thereof, wherein the therapeutically effective amount is 70 mg per day, 140 mg per day, or 200 mg per day. Also, a unit dosage form of ladostigil or a pharmaceutically active salt thereof in an amount of 50 mg, 70 mg, 80 mg or 100 mg.
    Type: Application
    Filed: October 20, 2009
    Publication date: April 15, 2010
    Inventors: Victor Piryatinsky, Bronka Cohen, David Lerner, Dalia Pinkert, Istvan Miskolczi, Yaacov Herzig, Hugo Gottlieb, Marta Weinstock-Rosin
  • Propargylated aminoindans, processes for preparation, and uses thereof
    Patent number: 7625946
    Abstract: This invention provides compounds having the structure: wherein R1 is methyl and R2 is H, or R1 is ethyl and R2 is hydroxymethyl; R3 is H or propargyl; and R4 is either H or t-butyloxycarbonyl; or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: December 1, 2009
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Victor Piryatinsky, Bronka Cohen, David Lerner, Dalia Pinkert, Istvan Miskolczi, Yaacov Herzig, Hugo Gottlieb
  • Enantiomers of amino-phenyl-acetic acid octadec-9-(z) enyl ester, their salts and their uses
    Publication number: 20080221209
    Abstract: Disclosed are enantiomers of amino-phenyl-acetic acid octadec-9-(Z)-enyl ester, and salts thereof, including pharmaceutical compositions, uses and a process for the manufacture thereof.
    Type: Application
    Filed: February 25, 2008
    Publication date: September 11, 2008
    Inventors: Yaacov Herzig, Jeffrey Sterling, Vladimir Ioffe, Yuriy Raizi, Istvan Miskolczi, Andras Zekany
  • Propargylated aminoindans, processes for preparation, and uses thereof
    Publication number: 20070203232
    Abstract: This invention provides compounds having the structure: wherein R1 is methyl and R2 is H, or R1 is ethyl and R2 is hydroxymethyl; R3 is H or propargyl; and R4 is either H or t-butyloxycarbonyl; or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
    Type: Application
    Filed: February 23, 2007
    Publication date: August 30, 2007
    Inventors: Victor Piryatinsky, Bronka Cohen, David Lerner, Dalia Pinkert, Istvan Miskolczi, Yaacov Herzig, Hugo Gottlieb
  • Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents
    Publication number: 20060173053
    Abstract: Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C12-C24 alkyl or C10-C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.
    Type: Application
    Filed: December 19, 2005
    Publication date: August 3, 2006
    Inventors: Meir Shinitzky, Irun Cohen, Raanan Margalit, Yaacov Herzig, Jeffrey Sterling, Gyorgy Toth, Istvan Miskolczi, Ferenc Rantal, Tivadar Tamas