Abstract: A co-aptive surgical instrument has a pair of opposite facing co-aptive surfaces for grasping tissue. The co-aptive surfaces are formed with a matrix layer which is preferably of a metal such as nickel with a plurality of hard crystalline particles which are preferably a diamond grit which is captured in the matrix. To insure sufficient capture of the particles in the matrix so as to avoid loss of particles while at the same time providing the maximum possible protrusion of the particles and maximum coverage of the surface by such particles, the particles are oriented in juxtaposition to evenly cover the surface and the matrix is made to have a depth which is at least fifty percent of the average diameter of the particles.

Abstract: A composition for enhancing vascular perfusion and reperfusion in disease states, both in man and animals comprising an aqueous solution having a slightly acidic pH, and suitable for intravenous use and containing glucose, insulin and Magnesium dipotassium ethylene diamine tetraacetic acid (MgK.sub.2 EDTA).