Patents by Inventor Ivan K. Dimov
Ivan K. Dimov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240075471Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: August 4, 2023Publication date: March 7, 2024Applicant: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 11759779Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: September 12, 2022Date of Patent: September 19, 2023Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20230173486Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: September 12, 2022Publication date: June 8, 2023Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20230166261Abstract: Described are systems and methods for particle sorting. An array may comprise a substrate with a first surface and a second surface opposite to the first surface. The substrate may comprise a plurality of pores defining lumens extending from the first surface to the second surface. The plurality of pores can be configured to receive a sample solution comprising a plurality of particles. The array may further comprise a surface material provided at or adjacent to the first or second surfaces. The surface material may comprise a plurality of materials that are configured to modify a wetting behavior of the sample solution or the plurality of particles at or adjacent to said first or second surfaces, such that one of the first or second surfaces is hydrophilic, and the other of the first or second surfaces is hydrophobic.Type: ApplicationFiled: September 1, 2022Publication date: June 1, 2023Inventors: Qiong PAN, Colm HUNT, Ivan K. DIMOV
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Patent number: 11471885Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: June 16, 2020Date of Patent: October 18, 2022Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20220250074Abstract: Methods and devices for creating monolayer arrays of cells or particles are described which may be used for high-throughput cell sorting and analysis, or other particle sorting applications. A cell loading system is described, the system comprising a porous mesh having a plurality of openings arranged in a random or repeating pattern across a surface. The porous mesh is used for preparing a layer of target particles, e.g., cells, distributed and spaced apart in a two-dimensional configuration on or within the mesh. Each of the plurality of openings in the mesh is configured to receive and permit a target particle to pass through when a fluid containing the target particles is dispensed on the surface of the mesh.Type: ApplicationFiled: March 8, 2022Publication date: August 11, 2022Inventors: Qiong PAN, Syed HUSAIN, Lagnajeet PRADHAN, Efrat HAREL, Ivan K. DIMOV, Colm HUNT, Wesley DONG
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Publication number: 20210339246Abstract: Described are platforms, systems, media, and methods for maintaining a database of items associated with one or more skill requirements and a visit duration; maintaining a database of experts associated with one or more skill proficiencies, a location, and a schedule; receiving a request from a consumer for delivery by an expert of one or more items in the database to a consumer address; identifying experts in the database having skill proficiencies matching the skill requirements of the one or more items and available in a timeslot for the visit duration of the one or more items; presenting timeslots for which one or more experts are identified to the consumer and allowing the consumer to select a timeslot; and selecting an expert from among the identified experts in the selected timeslot based on shortest travel time; provided that utilization of the selected expert exceeds a predetermined utilization threshold.Type: ApplicationFiled: February 24, 2021Publication date: November 4, 2021Inventors: Qiong PAN, Ivan K. DIMOV, Nathaniel FERNHOFF, Lagnajeet PRADHAN, Colm HUNT, Aren Argisht NAZARIAN, Catherine Chih-Tzu YIN
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Publication number: 20210263061Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.Type: ApplicationFiled: September 28, 2020Publication date: August 26, 2021Inventors: Ivan K. Dimov, Thomas M. Baer
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Publication number: 20210244763Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: ApplicationFiled: November 6, 2020Publication date: August 12, 2021Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Publication number: 20210016277Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: June 16, 2020Publication date: January 21, 2021Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 10857183Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: April 18, 2019Date of Patent: December 8, 2020Assignee: ORCA BIOSYSTEMS, INC.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Patent number: 10788506Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.Type: GrantFiled: April 19, 2017Date of Patent: September 29, 2020Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ivan K. Dimov, Thomas M. Baer
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Patent number: 10722885Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: May 29, 2019Date of Patent: July 28, 2020Assignee: ORCA BIOSYSTEMS, INC.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20200061612Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: May 29, 2019Publication date: February 27, 2020Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20190298773Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: ApplicationFiled: April 18, 2019Publication date: October 3, 2019Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Patent number: 10350595Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: July 24, 2018Date of Patent: July 16, 2019Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 10300090Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: March 15, 2018Date of Patent: May 28, 2019Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Publication number: 20180353960Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: July 24, 2018Publication date: December 13, 2018Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20180264039Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: ApplicationFiled: March 15, 2018Publication date: September 20, 2018Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Publication number: 20170292915Abstract: A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.Type: ApplicationFiled: April 19, 2017Publication date: October 12, 2017Inventors: Ivan K. Dimov, Thomas M. Baer