Patents by Inventor Ivan Kompis

Ivan Kompis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotic combination
    Patent number: 5721242
    Abstract: Pharmaceutical preparations containing an antibacterially-active synergistic combination of epiroprim and dapsone are useful in the treatment or control of infections caused by mycobacteria, Actinomycetes and toxoplasmosis pathogens.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 24, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Rudolf Then
  • Amino substituted pyrimido[1,6-2]benzimidazoles
    Patent number: 5283248
    Abstract: The present invention relates to novel substituted pyrimidobenzimidazole derivatives of the formula ##STR1## wherein the substituents are as described in the specification, and pharmaceutically acceptable salts thereof.The products have an inhibitory action on the DNA-gyrase activity in bacteria. They can accordingly be used for the prevention or control of bacterial infections.
    Type: Grant
    Filed: June 25, 1992
    Date of Patent: February 1, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christian Hubschwerlen, Ivan Kompis, Jean-Luc Specklin
  • Quinoline derivatives
    Patent number: 4977265
    Abstract: Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, X, Y, Z and n are as hereinafter described, and salts thereof, prepared starting from corresponding tricyclic compounds, are described. The compounds I and some of the said tricyclic compounds have antibacterial activity, and are therefore useful as antibacterial agents.
    Type: Grant
    Filed: May 15, 1990
    Date of Patent: December 11, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rita Locher, Ivan Kompis, Ekkehard Weiss, Pierre-Charles Wyss
  • Quinoline derivatives
    Patent number: 4946847
    Abstract: Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, X, Y, Z and n are as hereinafter described, and salts thereof, prepared starting from corresponding tricyclic compounds, are described. The compounds I and some of the said tricyclic compounds have antibacterial activity, and are therefore useful as antibacterial agents.
    Type: Grant
    Filed: November 21, 1988
    Date of Patent: August 7, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rita Locher, Ivan Kompis, Ekkehard Weiss, Pierre-Charles Wyss
  • Process for the methyl-4-(dimethylamino)-3,5-dimethoxybenzoate
    Patent number: 4908470
    Abstract: Methyl 4-dimethylamino-3,5-dimethoxybenzoate, an intermediate in the preparation of the antibacterially active aditoprim, is obtained from 4-amino-3,5-dibromobenzoic acid by replacement of the bromine atoms by methoxy groups and subsequent methylation.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: March 13, 1990
    Assignee: Hoffman-La Roche Inc.
    Inventors: Alfredo Guerrato, Martin Karpf, Hanny K. Berger, Ivan Kompis, Markus Schlageter
  • Quinoline derivatives
    Patent number: 4806541
    Abstract: Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, X, Y, Z and n are as herein described, and salts thereof, are described. The compounds of formula III have antibacterial activity, and are therefore useful as antibacterial agents.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: February 21, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rita Locher, Ivan Kompis, Ekkehard Weiss, Pierre-Charles Wyss
  • 2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyrimidine and antibacterial composition thereof
    Patent number: 4792557
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: December 20, 1988
    Assignee: Hoffman-La Roche Inc.
    Inventors: Ivan Kompis, G/e/ rald Rey-Bellet, Guido Zanetti
  • Pyrimidine derivatives for treating malaria
    Patent number: 4774249
    Abstract: The pyrimidine derivatives of formula I ##STR1## wherein R.sup.1 is naphthyl, substituted naphthyl or substituted phenyl; R.sup.2 is hydrogen or lower alkoxy; and A is an optionally present ethylene or 1,3-propylene, and wherein the diaminopyridine group has the exo-configuration when A is present, are described. These compounds are useful as antibacterial agents, antimalarial agents and antitumor agents, and can be used in combination with sulfonamides in the control of bacterial infections.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: September 27, 1988
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Rita Locher, Hans Maag
  • Intermediates for the preparation of substituted 2-phenyl-1,3-dioxolanes
    Patent number: 4720546
    Abstract: The compounds of the formula ##STR1## wherein one of the symbols Q and Q' is the group --CH.dbd. and the other is the group --CH.dbd. or --N.dbd., R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or halogen and n is the integer 0, 1 or 2, and their pharmaceutically acceptable acid addition salts, which have valuable antimycotic properties and can be used for the control of infections caused by pathogenic fungi, are described.
    Type: Grant
    Filed: November 4, 1986
    Date of Patent: January 19, 1988
    Assignee: Hoffman-La Roche Inc.
    Inventors: Ivan Kompis, Ekkehard Weiss
  • Intermediates for benzylpyrimidines
    Patent number: 4659818
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: April 21, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • Substituted 2-phenyl-1,3-dioxolanes
    Patent number: 4640918
    Abstract: The compounds of the formula ##STR1## wherein one of the symbols Q and Q' is the group --CH.dbd. and the other is the group --CH.dbd. or --N.dbd., R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or halogen and n is the integer 0, 1 or 2,and their pharmaceutically acceptable acid addition salts, which have valuable antimycotic properties and can be used for the control of infections caused by pathogenic fungi, are described.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: February 3, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Ekkehard Weiss
  • Process for the preparation of aqueous solutions of potentiated sulfonamides
    Patent number: 4599416
    Abstract: Aqueous solutions of antibacterially active sulfonamides and sulfonamide potentiators, which are suitable for parenteral administration and which contain no organic solvent, are prepared by reacting a sulfonamide RH with an aldehyde R.sup.1 CHO to give a compound of the formula R.sup.1 CH(R).sub.2 and dissolving said compound in water together with the sulfonamide potentiator.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Ivan Kompis
  • 2,4-diamino-[4-piperidinyl]pyrimidines useful as antibacterial agents, antimalarial agents, antitumors agents
    Patent number: 4590270
    Abstract: The pyrimidine derivatives of formula I ##STR1## wherein R.sup.1 is naphthyl, substituted naphthyl or substituted phenyl; R.sup.2 is hydrogen or lower alkoxy; and A is an optionally present ethylene or 1,3-propylene, and wherein the diaminopyridine group has the exo-configuration when A is present,are described. These compounds are useful as antibacterial agents, antimalarial agents and antitumor agents, and can be used in combination with sulfonamides in the control of bacterial infections.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: May 20, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Rita Locher, Hans Maag
  • Pharmaceutical compositions
    Patent number: 4532245
    Abstract: Pharmaceutical compositions of sulfonamide and sulfonamide-potentiator are disclosed. These compositions, which are suitable for injection administration, comprise an aldehyde in addition to the sulfonamide and its potentiator.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: July 30, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Ivan Kompis
  • 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
    Patent number: 4515948
    Abstract: 2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
    Type: Grant
    Filed: June 30, 1981
    Date of Patent: May 7, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • Benzaldehyde compounds
    Patent number: 4254286
    Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-6 -alkyl, R.sup.3 is C.sub.1-3 -alkyl and R.sup.4 is methylene or C.sub.2-4 -alkylidene and physiologically compatible acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.In yet another aspect, the invention relates to intermediates for the preparation of the compounds of formula I.
    Type: Grant
    Filed: October 22, 1979
    Date of Patent: March 3, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Alexander E. Wick
  • Benzylpyrimidines
    Patent number: 4251454
    Abstract: Benzylpyrimidines of the formula ##STR1##wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter described, are prepared. The benzylpyrimidines are useful as potentiators of the activity of the sulfonamides.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: February 17, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Gerald Rey-Bellet, Guido Zanetti
  • Benzylpyrimidine derivatives
    Patent number: 4203980
    Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-6 -alkyl, R.sup.3 isC.sub.1-3 -alkyl and R.sup.4 is methylene or C.sub.2-4 -alkylideneand physiologically compatible acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.
    Type: Grant
    Filed: April 26, 1978
    Date of Patent: May 20, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Alexander E. Wick
  • Benzylpyrimidines
    Patent number: 4191758
    Abstract: Benzylpyrimidines of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are C.sub.1-3 -alkyl, and R.sup.3 and R.sup.4, independently, are hydrogen or methyl,and physiologically acceptable acid addition salts thereof, are described. The compounds of formula I are useful as antibacterial agents and as potentiators of sulfonamides.
    Type: Grant
    Filed: April 26, 1978
    Date of Patent: March 4, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Alexander E. Wick
  • Preparation of 2,4-diamino-5-(4-amino-3,5-substituted-benzyl)-pyrimidines
    Patent number: 4137411
    Abstract: A benzylpyrimidines of the formula ##STR1## wherein r.sup.1 and R.sup.2 independently are C.sub.1-3 -alkyl or C.sub.1-3 -alkoxy, and R is hydrogen or lower alkyl, is treated with hydroxylamine or a salt thereof in polyphosphoric acid or alternatively, when R is hydrogen, is treated with sodium azide in polyphosphoric acid, to yield the corresponding 4-amino benzylpyrimidine.
    Type: Grant
    Filed: February 1, 1978
    Date of Patent: January 30, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ivan Kompis, Alexander E. Wick