Patents by Inventor Ivan M. Borrello

Ivan M. Borrello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF ACTIVATED T-CELLS TO ENHANCE ANTI-TUMOR ACTIVITY OF BISPECIFIC ANTIBODIES OR BITES
    Publication number: 20240091257
    Abstract: Provided herein are methods of treatment including methods of treating cancer and methods of enhancing an anti-tumoral activity of a bispecific T-cell engager (BiTE) or of a bispecific antibody. The methods disclosed herein include activating T-cells and contacting activated T-cells with BiTEs or bispecific antibodies for administration to a subject.
    Type: Application
    Filed: December 10, 2021
    Publication date: March 21, 2024
    Inventors: Ivan M. Borrello, Amy Thomas, Eric L. Smith
  • MARROW INFILTRATING LYMPHOCYTES (MILS) AS A SOURCE OF T-CELLS FOR CHIMERIC ANTIGEN RECEPTOR (CAR) THEREAPY
    Publication number: 20230210990
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a MIL obtained from bone marrow comprising a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Application
    Filed: November 30, 2022
    Publication date: July 6, 2023
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Drew M. Pardoll, Valentina Hoyos Velez
  • MARROW INFILTRATING LYMPHOCYTES (MILS) AS A SOURCE OF T-CELLS FOR CHIMERIC ANTIGEN RECEPTOR (CAR) THEREAPY
    Publication number: 20230016031
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Application
    Filed: September 15, 2022
    Publication date: January 19, 2023
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Drew M. Pardoll, Valentina Hoyos Velez
  • ACTIVATION OF MARROW INFILTRATING LYMPHOCYTES IN HYPOXIC ALTERNATING WITH NORMOXIC CONDITIONS
    Publication number: 20230000919
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: July 14, 2022
    Publication date: January 5, 2023
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Marrow infiltrating lymphocytes (MILs) as a source of T-cells for chimeric antigen receptor (CAR) therapy
    Patent number: 11478548
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: October 25, 2022
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Drew M. Pardoll, Valentina Hoyos Velez
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 11406666
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: August 9, 2022
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • ACTIVATION OF MARROW INFILTRATING LYMPHOCYTES IN HYPOXIC ALTERNATING WITH NORMOXIC CONDITIONS
    Publication number: 20220016172
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 20, 2022
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 11160830
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: November 2, 2021
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Use of Post-Transplant Cyclophosphamide Treated Allogenic Marrow Infiltrating Lymphocytes to Augment Anti-Tumor Immunity
    Publication number: 20200171089
    Abstract: The present invention relates to the field of cancer therapy. More specifically, the present invention provides methods and compositions useful for augmenting anti-tumor immunity. In one embodiment, a method for treating or preventing post-allogeneic transplant relapse in a subject who has received post-transplant cyclophosphamide treatment comprises the steps of (a) obtaining a bone marrow sample from the subject; (b) expanding the marrow infiltrating lymphocytes (MILs) present in the sample; and (c) administering the MILs to the subject. In a specific embodiment, the method significantly reduces the likelihood of developing GVHD.
    Type: Application
    Filed: December 30, 2019
    Publication date: June 4, 2020
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Ivan M. Borrello, Kimberly A. Noonan, Leonido Luznik
  • Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions
    Publication number: 20190350982
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: July 30, 2019
    Publication date: November 21, 2019
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions
    Publication number: 20190298768
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: December 3, 2018
    Publication date: October 3, 2019
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 10406178
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: September 10, 2019
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 10172887
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: January 8, 2019
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Marrow Infiltrating Lymphocytes (MILS) as a Source of T-Cells for Chimeric Antigen Receptor (CAR) Thereapy
    Publication number: 20180200367
    Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 19, 2018
    Inventors: Ivan M. Borrello, Susan Lee, Kimberly A. Noonan, Drew M. Pardoll
  • IMMUNE CHECKPOINT CHIMERIC ANTIGEN RECEPTORS THERAPY
    Publication number: 20180185434
    Abstract: In some aspects, the embodiments relate to compositions and methods related to chimeric transmembrane proteins. The chimeric transmembrane proteins may comprise the extracellular domain of an inhibitory receptor, and an intracellular signaling domain that can activate an immune response.
    Type: Application
    Filed: June 29, 2016
    Publication date: July 5, 2018
    Inventors: Ivan M. Borrello, Susan Lee, Kimberly A. Noonan, Drew M. Pardoll
  • Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions
    Publication number: 20170266232
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 21, 2017
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions
    Publication number: 20170258838
    Abstract: In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 14, 2017
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • PDE INHIBITORS IN IMMUNOTHERAPY
    Publication number: 20170224691
    Abstract: The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject.
    Type: Application
    Filed: September 19, 2016
    Publication date: August 10, 2017
    Inventors: Ivan M. Borrello, Paolo Serafini, Kimberly A. Noonan, Vincenzo Bronte
  • Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
    Patent number: 9687510
    Abstract: Various embodiments of the invention relate to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. Some embodiments relate to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. Some embodiments relate to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: June 27, 2017
    Assignee: The Johns Hopkins University
    Inventors: Ivan M. Borrello, Kimberly A. Noonan
  • ACTIVATION OF MARROW INFILTRATING LYMPHOCYTES IN HYPOXIC ALTERNATING WITH NORMOXIC CONDITIONS
    Publication number: 20160331781
    Abstract: Various embodiments of the invention relate to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. Some embodiments relate to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. Some embodiments relate to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
    Type: Application
    Filed: September 4, 2015
    Publication date: November 17, 2016
    Inventors: Ivan M. Borrello, Kimberly A. Noonan