Patents by Inventor Ivan R. Correia

Ivan R. Correia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral Inactivation During Purification of Antibodies
    Publication number: 20150344564
    Abstract: Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.
    Type: Application
    Filed: August 17, 2015
    Publication date: December 3, 2015
    Inventors: Robert K. Hickman, Ivan R. Correia
  • Viral inactivation during purification of antibodies cross reference to related applications
    Patent number: 9109010
    Abstract: Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: August 18, 2015
    Assignee: AbbVie Inc.
    Inventors: Robert K. Hickman, Ivan R. Correia
  • STABLE ANTIBODY COMPOSITIONS AND METHODS OF STABILIZING SAME
    Publication number: 20100172862
    Abstract: The invention provides compositions and methods for inhibiting fractionation of immunoglobulins comprising a lambda light chain based on the observation that iron, in the presence of histidine, results in increased fragmentation of a recombinant fully human IgG molecule containing a lambda light chain due to cleavage in the hinge region. The invention further provides an aqueous pharmaceutical formulation comprising an antibody, or antigen-binding portion thereof, that binds the p40 subunit of IL-12/IL-23 and a buffer system comprising histidine, wherein the formulation has enhanced stability, including enhanced resistance to fragmentation.
    Type: Application
    Filed: November 24, 2009
    Publication date: July 8, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Ivan R. Correia, Czeslaw H. Radziejewski, Wolfgang Fraunhofer, Nicholas W. Warne, Angela Kantor
  • VIRAL INACTIVATION DURING PURIFICATION OF ANTIBODIES CROSS REFERENCE TO RELATED APPLICATIONS
    Publication number: 20100136025
    Abstract: Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.
    Type: Application
    Filed: October 20, 2009
    Publication date: June 3, 2010
    Inventors: Robert K. Hickman, Ivan R. Correia