Abstract: Disclosed herein are methods for treating hyperparathyroidism, osteoporosis, or cancer cachexia, or inhibiting abnormally increased white adipose tissue browning, or decreasing the risk of a kidney stone in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a negative allosteric modulator of parathyroid hormone (PTH) type 1 receptor (PTHR) signaling.

Abstract: Disclosed herein are methods of identifying a compound for treating or preventing an infection with an infectious microbe, such as a coronavirus, in a subject in need thereof. Also disclosed herein are compounds and compositions identified by said methods, and methods of use thereof.

Abstract: Provided herein are methods of treating a COVID-19 infection in a subject, comprising administering to the subject an effective amount of a composition that reduces the superantigen character of SARS-CoV-2 Spike protein. In some embodiments, the compositions are mimetic peptides of the superantigen region. In some embodiments, the compositions are humanized antibodies, such as humanized mAb 6D3, that bind to the superantigen region.

Abstract: Provided herein are methods of treating a COVID-19 infection in a subject, comprising administering to the subject an effective amount of a composition that reduces the superantigen character of SARS-CoV-2 Spike protein. In some embodiments, the compositions are mimetic peptides of the superantigen region. In some embodiments, the compositions are humanized antibodies, such as humanized mAb 6D3, that bind to the superantigen region.

Abstract: The present invention involves the synthesis of a series of amylose (starch) derivatives with various degrees of substitution and amylose/amylopectin ratios. These chains are chemically crosslinked and then mechanically deformed (stretched) to produce a biodegradable and mechanically superior material. Specifically, the process consists of chemically modifying starch into starch derivatives such as starch ethers, starch esters and starch carbamates. The polymers have a percentage degree of substitution of from about 35% to about 95% (degree of substitution is from about 1.05 to about 2.85) and preferably have a percentage degree of substitution of from about 65% to about 90% (degree of substitution is from about 1.95 to about 2.70). The starch derivatives are crosslinked to obtain crosslinked chains and processed into sheets, films, fibers, threads or other articles as known in the art.

Abstract: The present invention involves the synthesis of a series of amylose (starch) derivatives with various degrees of substitution and amylose/amylopectin ratios. These chains are chemically crosslinked and then mechanically deformed (stretched) to produce a biodegradable and mechanically superior material. Specifically, the process consists of chemically modifying starch into starch derivatives such as starch ethers, starch esters and starch carbamates. The polymers have a percentage degree of substitution of from about 35% to about 95% (degree of substitution is from about 1.05 to about 2.85) and preferably have a percentage degree of substitution of from about 65% to about 90% (degree of substitution is from about 1.95 to about 2.70). The starch derivatives are crosslinked to obtain crosslinked chains and processed into sheets, films, fibers, threads or other articles as known in the art.