Patents by Inventor Ivo L. Jirkovsky
Ivo L. Jirkovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7276611Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of ?-lactamase inhibitors.Type: GrantFiled: May 12, 2004Date of Patent: October 2, 2007Assignee: Wyeth Holdings CorporationInventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
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Publication number: 20040242874Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification 1Type: ApplicationFiled: May 12, 2004Publication date: December 2, 2004Applicant: Wyeth Holdings CorporationInventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
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Patent number: 5389672Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl) methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.Type: GrantFiled: February 16, 1994Date of Patent: February 14, 1995Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 5389673Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl) methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.Type: GrantFiled: February 16, 1994Date of Patent: February 14, 1995Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 5389671Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl) methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.Type: GrantFiled: February 16, 1994Date of Patent: February 14, 1995Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 5314913Abstract: The present invention relates to novel 4- or 5-(substituted sulfonyl)methyl-3(2H)-furanones having the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl containing 1 to 6 branched or straight chain carbon atoms, phenyl, or halogen substituted phenyl; or R.sup.1 and R.sup.2 are joined by 5 to 7 carbon atoms;R.sup.3 and R.sup.4 are independently hydrogen, alkyl containing 1 to 6 branched or straight chain carbon atoms or R.sup.3 and R.sup.4 are joined by 4 to 6 carbon atoms;R.sup.Type: GrantFiled: December 8, 1992Date of Patent: May 24, 1994Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 5236941Abstract: 5-(2-Hydroxy-1-phenyl (or-1-naphthalenyl)ethylidene) and 5-(2-oxo-1-phenyl (or 1-naphthalenyl)ethylidene)-2,4-thiazolidinediones and derivatives thereof are useful in lowering blood glucose levels in a hyperglycemic laboratory animal model and are thus useful in the treatment of diabetes mellitus.Type: GrantFiled: June 30, 1992Date of Patent: August 17, 1993Assignee: American Home Products CorporationInventors: Arie Zask, Ivo L. Jirkovsky
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Patent number: 5118675Abstract: The compounds of the formula: ##STR1## in which Q is the quinoxaline nucleus; m is one of the integers 0, 1 or 2; n is one of the integers 1,2 or 3; or a pharmaceutically acceptable salt, alkyl ester or ##STR2## where R.sup.3 and R.sup.4 are, independently, hydrogen, nitro, halo or methoxy, are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.Type: GrantFiled: February 15, 1991Date of Patent: June 2, 1992Assignee: American Home Products CorporationInventors: Ivo L. Jirkovsky, Reinhardt B. Baudy, Lynne P. Greenblatt
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Patent number: 5026725Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.Type: GrantFiled: February 23, 1990Date of Patent: June 25, 1991Assignee: American Home Products CorporationInventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
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Patent number: 5017601Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkythio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.Type: GrantFiled: August 23, 1990Date of Patent: May 21, 1991Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 5010102Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substiuents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.Type: GrantFiled: August 23, 1990Date of Patent: April 23, 1991Assignee: American Home Products Corp.Inventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 5001126Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.Type: GrantFiled: August 23, 1990Date of Patent: March 19, 1991Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 4966905Abstract: A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.Type: GrantFiled: December 12, 1989Date of Patent: October 30, 1990Assignee: American Home Products CorporationInventors: Steven W. Felman, Ivo L. Jirkovsky, Kevin A. Memoli
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Patent number: 4916241Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.Type: GrantFiled: June 6, 1988Date of Patent: April 10, 1990Assignee: American Home Products CorporationInventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
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Patent number: 4778812Abstract: Herein is disclosed 2,3-dihydro-9-methyl-1H-pyrrolo[1,2-a]indol-1-amines and derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives, and pharmaceutical compositions. The derivatives are chemically novel agents with antihypoxic, cerebroactive, and cognition activating properties.Type: GrantFiled: June 12, 1987Date of Patent: October 18, 1988Assignee: American Home Products CorporationInventor: Ivo L. Jirkovsky
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Patent number: 4492697Abstract: The invention discloses novel 4H-imidazo[2,3-c]pyrido[2,3-e][1,4]oxazine derivatives, processes for their preparation, pharmaceutical compositions thereof and methods for using the compounds. The compounds of this invention are useful in the treatment of anaphylactic reactions and allergic conditions in a mammal.Type: GrantFiled: August 16, 1983Date of Patent: January 8, 1985Assignee: Ayerst, McKenna & Harrison, Inc.Inventors: Jean A. Gauthier, Ivo L. Jirkovsky
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Patent number: 4409224Abstract: Pyrimido[1,6-a]indole derivatives characterized by having a substituted ethyl group at position 5 and optionally being further substituted at various positions on the pyrimido[1,6-a]indole nucleus are disclosed. The foregoing compounds are useful as antihypertensive agents in a mammal. Methods for their preparation also are disclosed.Type: GrantFiled: July 13, 1981Date of Patent: October 11, 1983Assignee: American Home Products Corp.Inventor: Ivo L. Jirkovsky
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Patent number: 4355031Abstract: Pyrazinoisoindolone derivatives of the formula ##STR1## wherein R.sup.1 is lower alkyl, phenyl, diphenylmethyl, pyridinyl, pyrimidinyl, pyrazinyl or pyrazinyl substituted with a lower alkyl, lower alkoxy or halo; and R.sup.2 is hydrogen, lower alkyl or di(lower)alkylamino(lower)alkyl are useful as antihypertensive agents.Type: GrantFiled: May 11, 1981Date of Patent: October 19, 1982Assignee: American Home Products Corp.Inventors: Christopher A. Demerson, Ivo L. Jirkovsky
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Patent number: 4351942Abstract: A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.Type: GrantFiled: January 7, 1980Date of Patent: September 28, 1982Assignee: American Home Products Corp.Inventors: Thomas A. Dobson, Leslie G. Humber, Christopher A. Demerson, Ivo L. Jirkovsky
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Patent number: 4307234Abstract: Pyrimido[1,6-a]indole derivatives characterized by having a substituted ethyl group at position 5 and optionally being further substituted at various positions on the pyrimido[1,6-a]indole nucleus are disclosed. The foregoing compounds are useful as antihypertensive agents in a mammal. Methods for their preparation also are disclosed.Type: GrantFiled: September 11, 1978Date of Patent: December 22, 1981Assignee: American Home Products Corp.Inventor: Ivo L. Jirkovsky