Abstract: The present invention relates to a herbicide delivery method and a product for delivery to a plant wherein the plant has a generally hollow stem. A particular example of such a plant is Japanese knotweed. The present invention relates to a method of administering a herbicide to a plant comprising the steps of providing an opening in the stem of a plant wherein the stem comprises a tubular portion having a cavity therein and inserting a consumable delivery means comprising at least a herbicide into the opening in the stem of the plant. The herbicide may be provided in a consumable capsule.

Abstract: A strain of Francisella species in which gene FTT1564, or homologue thereof, has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Other embodiments of the invention describe strains which comprise a further genetic mutation wherein additional genes are also inactivated. Pharmaceutical compositions comprising said strains, together with methods of preventing and treating tularemia infection, which utilise such strains, are also described and claimed.