Patents by Inventor Iwao Ohtsu

Iwao Ohtsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability
    Patent number: 9611461
    Abstract: L-cysteine can be produced inexpensively and efficiently by using a bacterium belonging to the family Enterobacteriaceae modified to reduce activity of O-acetylserine sulfhydrylase B thereof, the bacterium being modified so that the C terminal region of its thiosulfate-binding protein is deleted, and the bacterium having an increased ability to produce L-cysteine in the presence of a sulfate.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 4, 2017
    Assignee: National University Corporation Nara Institute of Science and Technology
    Inventors: Iwao Ohtsu, Takeshi Nakatani, Ai Tamakoshi, Sayo Takahashi, Hiroshi Takagi
  • ENTEROBACTERIACEAE BACTERIA EXHIBITING INCREASED L-CYSTEINE PRODUCING ABILITY
    Publication number: 20160272952
    Abstract: L-cysteine can be produced inexpensively and efficiently by using a bacterium belonging to the family Enterobacteriaceae modified to reduce activity of O-acetylserine sulfhydrylase B thereof, the bacterium being modified so that the C terminal region of its thiosulfate-binding protein is deleted, and the bacterium having an increased ability to produce L-cysteine in the presence of a sulfate.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 22, 2016
    Applicant: National University Corporation Nara Institute of Science and Technology
    Inventors: Iwao Ohtsu, Takeshi Nakatani, Ali Tamakoshi, Sayo Takahashi, Hiroshi Takagi
  • L-cysteine-producing bacterium and a method for producing L-cysteine
    Patent number: 8293506
    Abstract: The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine and has been modified to increase the activity of the protein encoded by the dsbA gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof can be collected from the medium.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: October 23, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Gen Nonaka, Hiroshi Takagi, Iwao Ohtsu, Natthawut Wiriyathanawudhiwong, Takeshi Nakatani
  • L-cysteine-producing bacterium and a method for producing L-cysteine
    Patent number: 8278075
    Abstract: L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2, (b) a protein comprising the amino acid sequence of SEQ ID NO: 2, but wherein one or several amino acid residues are substituted, deleted, inserted or added, increase of which activity in the bacterium improves the ability of the bacterium to produce L-cysteine.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: October 2, 2012
    Assignees: Ajinomoto Co., Inc., National University Corporation Nara Institute of Science and Technology
    Inventors: Gen Nonaka, Hiroshi Takagi, Iwao Ohtsu
  • L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE
    Publication number: 20110033902
    Abstract: L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2, (b) a protein comprising the amino acid sequence of SEQ ID NO: 2, but wherein one or several amino acid residues are substituted, deleted, inserted or added, increase of which activity in the bacterium improves the ability of the bacterium to produce L-cysteine.
    Type: Application
    Filed: August 18, 2010
    Publication date: February 10, 2011
    Inventors: Gen Nonaka, Hiroshi Takagi, Iwao Ohtsu
  • L-CYSTEINE-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING L-CYSTEINE
    Publication number: 20100216196
    Abstract: The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine and has been modified to increase the activity of the protein encoded by the dsbA gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof can be collected from the medium.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 26, 2010
    Inventors: Gen Nonaka, Hiroshi Takagi, Iwao Ohtsu, Natthawut Wiriyathanawudhiwong, Takeshi Nakatani