Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.

Abstract: Light controlled switching modules are provide. In embodiments, a light controlled switching module includes: a housing; a light controlled semiconductor switch mounted to the housing, the light controlled semiconductor switch including a semiconductor body; at least one light source mounted to the housing in a spaced relationship from the light controlled semiconductor switch and positioned to direct light emitted from the at least one light source toward the semiconductor body; and first and second electrodes mounted to the housing and connected to the light controlled semiconductor switch, wherein the first and second electrodes are configured to have variable resistance between the first and the second electrode.

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.

Abstract: An engine friction monitor uses commanded torque and measured torque to provide a prognostic feature to identify failure modes of an engine that causes the engine from delivering the commanded torque.

Abstract: A latching arrangement by which a tray arrangement is releasably held in one or more positions relative to a chassis is at least partially actuated by a cable guide extending forwardly from the tray arrangement. In some example latching arrangements, the cable guide is pivoted relative to the tray arrangement to release a stop member from the chassis. In other example latching arrangements, the cable guide is slid relative to the tray arrangement to release the stop member. Certain types of latching arrangements have a second stop member that is separately actuated by a different part (e.g., an actuation leg) of the latching arrangement.

Abstract: The invention provides a transgenic corn event MON 95379, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON 95379. The invention also provides polynucleotides specific for event MON 95379 and methods for using and detecting event MON 95379 as well as plants, plant cells, seeds, plant pails, progeny plants, and commodity products comprising event MON 95379.

Abstract: Whenever an avionics computer system receives a flight plan, the avionics computer system performs rules-based conformity checks with respect to a predefine set of rules/thresholds. The rules may be general aviation best practices (no rate of elevation change beyond some threshold, no single change in direction beyond some threshold, etc.) or specific to the aircraft (no violation of an operational ceiling, no violation of some defined fuel reserve, etc.). Violations of the rules and criteria are communicated to crew members via visual indicia of such violations, including the relative severity.

Abstract: A zero turning radius mower park brake system includes a pair of steering levers attached to steering arm brackets that are pivotable forward and reverse on a first axis for rotating a pair of traction drive wheels in forward or reverse, and pivotable outwardly on a second axis while in a neutral position. A wire cable connects each steering arm bracket to a park brake. The wire cable retracts sufficiently to actuate the park brake when the steering arm bracket is pivoted outwardly on the second axis, but does not actuate the park brake when the steering arm bracket it pivoted forward or reverse. At least one spring provides a force urging the park brake into engagement when the steering arm pawls to park brake engaged position.

Abstract: Organometallic radiation resist compositions are described based on tin ions with alkyl ligands. Some of the compositions have branched alkyl ligands to provide for improved patterning contrast while maintaining a high degree of solution stability. Blends of compounds with distinct alkyl ligands can provide further improvement in the patterning. High resolution patterning with a half-pitch of no more than 25 nm can be achieved with a line width roughness of no more than about 4.5 nm. Synthesis techniques have been developed that allow for the formation of alkyl tin oxide hydroxide compositions with very low metal contamination.

Abstract: The beverage brewing device, which is configured for use with a beverage brewer having an inlet probe for dispensing water and an outlet probe, includes a body defining a brew chamber configured to contain a dry beverage medium and at least one outlet probe receptacle extending upwardly from a bottom surface of the body. The outlet probe receptacle is sized and configured to receive an outlet probe of a beverage brewer. A lid is removably securable to the body and is engageable with the body to selectively enclose a top opening of the body. An inlet probe opening is defined in the lid for receiving an inlet probe of the beverage brewer. At least one filter is defined within in the body, wherein the filter is configured to retain a dry beverage medium within the brew chamber while allowing a brewed beverage to pass through the brew chamber.

Abstract: The spinal cord stimulation device of this invention is configured for implantation into a patient so as to traverse the dura mater that surrounds the spinal cord. Placing the device in this location provides direct contact between the electrode and the cerebrospinal fluid (CSF), in close proximity to the spinal cord. The device has an intradural portion and an extradural portion that compresses and seals the dural membrane between them, securing the device in position and preventing leakage of CSF. The position of the device may be stabilized in relation to the spinal cord by way of a laminoplasty plate, bridging between the device and a vertebra. The device is electronically powered by an implanted pulse generator that produces a spectrum of signals to interrupt or otherwise attenuate transmission of pain mediating neural signals through the spinal cord.

Abstract: Methods and systems are provided for locking assemblies of a pair of bridge plates placed between adjacent railcars. In one example, a bridge plate assembly may include a locking assembly with a guide tube shifted to a side from a center of a bridge plate and a pivot pin coupled to the guide tube protruding out of a left side or a right side of the bridge plate.

Abstract: The present disclosure is directed to a computer-assisted or autonomous driving (CA/AD) vehicle with a controller to control one or more light emitters to produce a light pattern that uniquely identify the vehicle. It may also be directed to a system to receive image data from one or more video cameras located in a location vicinity of the CA/AD vehicle emitting a pattern of light, and to analyze the received image data to determine a physical location of the vehicle.

Abstract: Photocatalysts and methods of making and using the same are disclosed. The photocatalyst includes a TIO2 ultra-nanoparticle having a single Fe, Co, Mn, Cr, or W atom positioned as an engineered defect within the particle and a single metal catalyst atom bound proximal to the single Fe, Co, Mn, Cr, or W atom. The method of making the photocatalyst includes generating a plurality of ultra-nano TIO2 particles, each having a single Fe, Co, Mn, Cr, or W atom positioned as an engineered defect within the particle. The method further includes photodepositing a single metal catalyst atom proximal to the single Fe, Co, Mn, Cr, or W atom for at least a portion of the ultra-nano TIO2 particles, thereby creating the disclosed photocatalyst. The single metal catalyst atom is in a positive oxidation state and can be Pt, Pd, Ir, Ru, Rh, Os, Re, Au, Ni, Zn, or Cu.

Abstract: A system for protecting cards may include, but is not limited to: a sleeve portion including: a first sleeve panel; a second sleeve panel, and a sleeve perimeter portion, wherein the sleeve perimeter portion retains the first sleeve panel and the second sleeve panel in a spaced-apart configuration defining a sleeve slot; and a cap portion configured to be removably coupled to the card sleeve so as to at least partially cover the sleeve slot.

Abstract: An optical film includes a structured film and a light control film formed on the structured film. The structured film includes a substrate and a plurality of polymeric microstructures formed on a major surface of the substrate. Each microstructure includes an optical facet and a sidewall meeting the optical facet at a ridge of the microstructure. The light control film includes an optically transparent material disposed on and covering the plurality of polymeric microstructures, and a plurality of optically absorptive louvers formed in the optically transparent material opposite the structured film. The louvers extend along a longitudinal direction and are spaced apart along an orthogonal transverse direction. The louvers have an average depth D into the optically transparent material and have an average width W in the transverse direction. D/W can be greater than 2. The optical film is integrally formed.

Abstract: In some examples, a system includes an article of personal protective equipment (PPE) having at least one sensor configured to generate a stream of usage data; and an analytical stream processing component comprising: a communication component that receives the stream of usage data; a memory configured to store at least a portion of the stream of usage data and at least one model for detecting a safety event signature, wherein the at least one model is trained based as least in part on a set of usage data generated by one or more other articles of PPE of a same type as the article of PPE; and one or more computer processors configured to: detect the safety event signature in the stream of usage data based on processing the stream of usage data with the model, and generate an output in response to detecting the safety event signature.

Abstract: In various embodiments, crowd sourcing techniques are provided to determine beacon altitudes that may then be used in 3D positioning of UE. Some techniques may crowd source beacon altitudes based on global navigation satellite system (GNSS) position fixes obtained by UE. Other techniques may crowd source beacon altitudes based on uncalibrated pressure measurements obtained by UE. Still other techniques may combine beacon altitude crowd-sourcing and pressure sensor calibration on UE. Such techniques may make inferences based on line of sight (LOS) between UE and beacons, determined using signal strength, connection status, and/or timing measurement. The techniques may be implemented separately, or as part of a combined system that determines beacon altitudes in diverse manners. Once beacon altitudes are known, that may be used to determine 3D positions of the UE (e.g., by trilateration, multilateration or other positioning techniques).

Abstract: Annotations for a map of a worksite are generated by a controller. The controller receives georeferenced crop state data and georeferenced agricultural characteristic data, collectively referred to as agronomy data. The georeferenced crop state data and georeferenced agricultural characteristic data are analyzed by the controller to determine relationships therebetween. The controller generates the annotations based on the determined relationships. The controller generates explanations, which are type of annotation, based on determined relationships between current agronomy data and historical agronomy data.

Abstract: An optical film has a major surface including a plurality of microstructures. Each microstructure includes an optical facet and a sidewall meeting the optical facet at a ridge of the microstructure. The optical facet and the sidewall define an oblique angle therebetween. For each microstructure in at least a majority of the microstructures, an optically absorptive layer is disposed on the sidewall. The optical film can include a polymeric layer having a microstructured surface at least partially coated with an inorganic optically transparent layer. The optically absorptive layer can an average thickness t where 100 nm<t<1 micrometer. A first layer can be disposed between the sidewall and the optically absorptive layer where the first layer has a lower extinction coefficient than the optically absorptive layer.