Patents by Inventor J. B. Williams
J. B. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10214774Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: May 2, 2014Date of Patent: February 26, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Peter Williams, Daniel J. B. Williams, Linda Bloom, Thomas J. Taylor
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Patent number: 10208341Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: May 2, 2014Date of Patent: February 19, 2019Assignee: Life Technologies CorporationInventors: Peter Williams, Daniel J. B. Williams, Linda Bloom, Thomas J. Taylor
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Patent number: 9705870Abstract: A system and method for exchanging identity information and for correlating protected data across independent data systems connected through a network is disclosed. The system contains connectors in communication with protected data systems which house the protected data. Edge servers in communication with the connectors store correlation data sets that correlate protected data records using permanent tokens generated by the connectors. Root servers in communication with the edge servers store identity correlations generated by the root servers and propagated to the edge servers. Data identifiers used in the protected data system are correlated with distinct data identifiers used in the edge and root servers. The correlations are propagated throughout the edge servers so that each data system can transfer data to another data system without using the protected data identifiers.Type: GrantFiled: October 24, 2014Date of Patent: July 11, 2017Assignee: Verato, Inc.Inventors: J. B. Williams, Dennis Tackett, Dennis Rizzi
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Patent number: 9621357Abstract: A system and method for managing consent for an enterprise to, for example, provide access to controlled data to another enterprise wherein the controlled data can be in the form of subject data records. The system includes a consent management module operative to associate a plurality of control levels with a subject data record and process a consent request requesting access to the controlled data. Access is determined based on the control levels associated with a subject of the controlled data, a requesting operator, and/or the controlled data itself, A control level data set comprising the control levels for use in controlling access to the controlled data and/or subject data records is stored in a database.Type: GrantFiled: October 16, 2014Date of Patent: April 11, 2017Assignee: VERATO, INC.Inventors: J. B. Williams, Tara Figley
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Patent number: 9458500Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: June 8, 2013Date of Patent: October 4, 2016Assignee: Life Technologies CorporationInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20160119341Abstract: A system and method for exchanging identity information and for correlating protected data across independent data systems connected through a network is disclosed. The system contains connectors in communication with protected data systems which house the protected data. Edge servers in communication with the connectors store correlation data sets that correlate protected data records using permanent tokens generated by the connectors. Root servers in communication with the edge servers store identity correlations generated by the root servers and propagated to the edge servers. Data identifiers used in the protected data system are correlated with distinct data identifiers used in the edge and root servers. The correlations are propagated throughout the edge servers so that each data system can transfer data to another data system without using the protected data identifiers.Type: ApplicationFiled: October 24, 2014Publication date: April 28, 2016Applicant: ARAXID PRIME, INC.Inventors: J. B. Williams, Dennis Tackett, Dennis Rizzi
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Patent number: 9096898Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: December 16, 2010Date of Patent: August 4, 2015Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20140342365Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: May 2, 2014Publication date: November 20, 2014Applicant: Life Technologies CorporationInventors: Peter Williams, Daniel J.B. Williams, Linda Bloom, Thomas J. Taylor
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Publication number: 20140335509Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: May 2, 2014Publication date: November 13, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Peter Williams, Daniel J.B. Williams, Linda Bloom, Thomas J. Taylor
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Publication number: 20130295560Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: June 8, 2013Publication date: November 7, 2013Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20130288235Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: May 14, 2013Publication date: October 31, 2013Inventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20120258449Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: February 29, 2012Publication date: October 11, 2012Applicant: ARIZONA BOARD OF REGENTSInventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
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Patent number: 8263364Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: January 18, 2011Date of Patent: September 11, 2012Assignee: Arizona Board of RegentsInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
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Patent number: 8263365Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: January 18, 2011Date of Patent: September 11, 2012Assignee: Arizona Board of RegentsInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
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Patent number: 8216514Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: GrantFiled: June 8, 2011Date of Patent: July 10, 2012Assignee: Arizona Board of RegentsInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20120015353Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: June 8, 2011Publication date: January 19, 2012Applicant: HELICOS BIOSCIENCES CORPORATIONInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20110294115Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: May 3, 2011Publication date: December 1, 2011Applicant: ARIZONA BOARD OF REGENTSInventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20110183322Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: January 18, 2011Publication date: July 28, 2011Applicant: ARIZONA BOARD OF REGENTSInventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20110183321Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: December 16, 2010Publication date: July 28, 2011Applicant: ARIZONA BOARD OF REGENTSInventors: Peter Williams, Thomas J. Taylor, Daniel J.B. Williams, Ian Gould, Mark A. Hayes
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Publication number: 20110183323Abstract: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.Type: ApplicationFiled: January 18, 2011Publication date: July 28, 2011Applicant: ARIZONA BOARD OF REGENTSInventors: Peter Williams, Thomas J. Taylor, Daniel J. B. Williams, Ian Gould, Mark A. Hayes