Patents by Inventor J. Bruce German

J. Bruce German has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240010693
    Abstract: An antibacterial polypeptide and methods of use are described.
    Type: Application
    Filed: November 10, 2021
    Publication date: January 11, 2024
    Inventors: Ishita M. SHAH, J. Bruce GERMAN, David A. MILLS, Carlito B. LEBRILLA
  • Publication number: 20230190777
    Abstract: Methods and compositions for use of human milk oligosaccharides for prevention and treatment of airway viral infections are provided.
    Type: Application
    Filed: June 2, 2021
    Publication date: June 22, 2023
    Inventors: Ishita M. SHAH, David A. MILLS, J. Bruce GERMAN, Xi CHEN
  • Patent number: 11633461
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: April 25, 2023
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Publication number: 20220325305
    Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.
    Type: Application
    Filed: June 22, 2022
    Publication date: October 13, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyria Boundy-Mills, Luis Antonio Garay Almada, Irnayuli Rosaleida Sitepu, J. Bruce German, Tomas Cajka, Oliver Fiehn
  • Publication number: 20220280581
    Abstract: The combination of specific immunoglobulins plus activated Bifidobacteria strains or other beneficial bacteria is described with the designed efficacy to colonize unstable microbiome communities in humans or other animals, restoring the keystone Bifidobacteria strains or other beneficial bacteria to compositional and functional importance in the intestine and improve overall health and reduce pathogenic infections in the host. Secretory immunoglobulin A (SIgA), when bound via specific glycans to select commensal bacteria grown on human milk oligosaccharides (HMOs), enhances the colonization potential of commensals through protection from intestinal digestion, enhancing attachment, and dampening host immune response.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 8, 2022
    Inventors: Vanessa DUNNE-CASTAGNA, David MILLS, J. Bruce GERMAN
  • Patent number: 11401539
    Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 2, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyria Boundy-Mills, Luis Antonio Garay Almada, Irnayuli Rosaleida Sitepu, J. Bruce German, Tomas Cajka, Oliver Fiehn
  • Publication number: 20220160799
    Abstract: Provided are compositions and methods for treating, ameliorating and preventing various infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor, where exemplary compositions are products of manufacture, a food, a drink, a nutraceutical, a dietary supplement, a formulation, a pharmaceutical or a pharmaceutical preparation comprising at least one or several of: a plurality of isolated, or substantially purified bacteriophages or prophages, or bacteriophage subunits, a milk, a milk product, milk lipid, milk fat globule (MFG) macromolecule, a milk mucin, a milk glycolipid, a milk free glycan, a milk mucin-like glycoprotein, a milk protein, a milk sugar or lactose, a milk fat or butterfat, a milk vitamin.
    Type: Application
    Filed: December 2, 2021
    Publication date: May 26, 2022
    Inventors: Forest ROHWER, Jeremy J. BARR, J. Bruce GERMAN
  • Patent number: 11260089
    Abstract: Provided are compositions and methods for treating, ameliorating and preventing various infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor, where exemplary compositions are products of manufacture, a food, a drink, a nutraceutical, a dietary supplement, a formulation, a pharmaceutical or a pharmaceutical preparation comprising at least one or several of a plurality of isolated, or substantially purified bacteriophages or prophages, or bacteriophage subunits, a milk, a milk product, milk lipid, milk fat globule (MFG) macromolecule, a milk mucin, a milk glycolipid, a milk free glycan, a milk mucin-like glycoprotein, a milk protein, a milk sugar or lactose, a milk fat or butterfat, a milk vitamin.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: March 1, 2022
    Assignees: SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, THE REGENTS OF THE UNIVERSITY OE CALIFORNIA
    Inventors: Forest Rohwer, Jeremy J. Barr, J. Bruce German
  • Publication number: 20210308235
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: April 16, 2021
    Publication date: October 7, 2021
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Patent number: 11000576
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Garlito B. Lebrilla, David A. Mills
  • Patent number: 10918653
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 16, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Publication number: 20200345818
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: May 11, 2020
    Publication date: November 5, 2020
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Patent number: 10688160
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: June 23, 2020
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Patent number: 10639357
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: May 5, 2020
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Publication number: 20200078384
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Application
    Filed: October 29, 2019
    Publication date: March 12, 2020
    Inventors: J. Bruce GERMAN, David MILLS, Carlito B. LEBRILLA, Daniela BARILE, Riccardo LoCASCIO
  • Publication number: 20200030418
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: September 3, 2019
    Publication date: January 30, 2020
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Publication number: 20190381150
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Application
    Filed: September 3, 2019
    Publication date: December 19, 2019
    Inventors: Daniel GARRIDO, J. Bruce GERMAN, Carlito B. LEBRILLA, David A. MILLS
  • Publication number: 20190350950
    Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
    Type: Application
    Filed: February 12, 2019
    Publication date: November 21, 2019
    Inventors: J. Bruce GERMAN, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
  • Patent number: 10471134
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: November 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • Publication number: 20190119707
    Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 25, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyria Boundy-Mills, Luis Antonio Garay Almada, Irnayuli Rosaleida Sitepu, J. Bruce German, Tomas Cajka, Oliver Fiehn