Patents by Inventor J. Peter Klein

J. Peter Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LPAAT-BETA INHIBITORS AND USES THEREOF
    Publication number: 20100189726
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.
    Type: Application
    Filed: September 29, 2009
    Publication date: July 29, 2010
    Applicant: Cell Therapeutics, Inc.
    Inventors: Lynn BONHAM, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung, Baoqing Gong, John Tulinsky
  • Aryl triazines as LPAAT-? inhibitors and uses thereof
    Patent number: 7618968
    Abstract: The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: November 17, 2009
    Assignee: Cell Therapeutics, Inc.
    Inventors: Rama Bhatt, Baoqing Gong, Feng Hong, Scott A Jenkins, J Peter Klein, Anil M Kumar, John Tulinsky
  • LPAAT-? inhibitors and uses thereof
    Patent number: 7608620
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 27, 2009
    Assignee: Cell Therapeutics, Inc.
    Inventors: Lynn Bonham, Baoqing Gong, Robert E Finney, David M Hollenback, J Peter Klein, David W Leung, Scott A Shaffer, Norina M Tang, John Tulinsky, Thayer H White
  • PYRIMIDINES AND USES THEREOF
    Publication number: 20090099183
    Abstract: The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor-cells.
    Type: Application
    Filed: August 19, 2008
    Publication date: April 16, 2009
    Applicant: Cell Therapeutics, Inc.
    Inventors: Rama BHATT, Baoqing GONG, Feng HONG, Scott A. JENKINS, J. Peter KLEIN, Cory T. KOHM, John TULINSKY
  • Pyrimidines and uses thereof
    Patent number: 7419984
    Abstract: The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor-cells.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: September 2, 2008
    Assignee: Cell Therapeutics, Inc.
    Inventors: Rama Bhatt, Baoqing Gong, Feng Hong, Scott A Jenkins, J Peter Klein, Cory T Kohm, John Tulinsky
  • Manufacture of polyglutamate-therapeutic agent conjugates
    Patent number: 7399860
    Abstract: The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates prepared by these processes.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: July 15, 2008
    Assignee: Cell Therapeutics Inc.
    Inventors: Anil M. Kumar, J. Peter Klein, Rama Bhatt, Edward Vawter
  • Aryl triazines as LPAAT-? inhibitors and uses thereof
    Patent number: 7291616
    Abstract: The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: November 6, 2007
    Assignee: Cell Therapeutics, Inc.
    Inventors: Rama Bhatt, Baoqing Gong, Feng Hong, Scott A. Jenkins, J. Peter Klein, Anil M. Kumar, John Tulinsky
  • Uses of tricyclic compounds
    Patent number: 7247630
    Abstract: Novel tricyclic compounds are disclosed having the general structure of Formulas I or II: were R1, R2 and R3 are defined in the written description of the invention. The compounds are useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by intracellular cytokine signaling.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: July 24, 2007
    Assignee: Cell Therapeutics, Inc.
    Inventors: Baoqing Gong, J. Peter Klein, Michael Coon
  • Pyridines and uses thereof
    Patent number: 7208507
    Abstract: The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: April 24, 2007
    Assignee: Cell Therapeutics, Inc.
    Inventors: Feng Hong, J Peter Klein
  • LPAAT-? inhibitors and uses thereof
    Patent number: 7199238
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: April 3, 2007
    Assignee: Cell Therapuetics, Inc.
    Inventors: Lynn Bonham, Baoqing Gong, Robert E Finney, David M Hollenback, J. Peter Klein, David W Leung, Scott A Shaffer, Norina M Tang, John Tulinsky, Thayer H White
  • Polyglutamic acid-camptothecin conjugates and methods of preparation
    Patent number: 7173041
    Abstract: The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: February 6, 2007
    Assignee: Cell Therapeutics Inc.
    Inventors: Rama Bhatt, Peter de Vries, J. Peter Klein, John Tulinsky, Robert A. Lewis, Jack W. Singer
  • Polyglutamic acid-camptothecin conjugates and methods of preparation
    Patent number: 7153864
    Abstract: The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: December 26, 2006
    Assignee: Cell Therapeutics Inc.
    Inventors: Rama Bhatt, Peter de Vries, J. Peter Klein, John Tulinsky, Robert A. Lewis, Jack W. Singer
  • LPAAT-? inhibitors and uses thereof
    Patent number: 7064125
    Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 20, 2006
    Assignee: Cell Therapeutics, Inc.
    Inventors: Baoqing Gong, John Tulinsky, Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
  • Compounds having selective hydrolytic potentials
    Patent number: 7053096
    Abstract: Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: May 30, 2006
    Assignee: Cell Therapeutics Inc.
    Inventors: David Porubek, Anil M. Kumar, Charles R. Bredl, J. Peter Klein
  • Therapeutic compounds for inhibiting interleukin-12 signals and method for using same
    Patent number: 6878715
    Abstract: Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 (“IL-12”) intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N, N(R3) and S.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: April 12, 2005
    Assignee: Cell Therapeutics, Inc.
    Inventors: J. Peter Klein, Stephen J. Klaus, Anil M. Kumar, Baoqing Gong
  • Pyridines and uses thereof
    Patent number: 6875781
    Abstract: The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: April 5, 2005
    Assignee: Cell Therapeutics, Inc.
    Inventors: Feng Hong, J. Peter Klein
  • Pyridopyrimidine compounds and their uses
    Patent number: 6825180
    Abstract: Novel pyridopyrimidine-based compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: November 30, 2004
    Assignee: Cell Therapeutics, Inc.
    Inventors: Marc J. McKennon, J. Peter Klein, Michael Coon
  • Compounds having selective hydrolytic potentials
    Publication number: 20040229836
    Abstract: Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems.
    Type: Application
    Filed: May 5, 2004
    Publication date: November 18, 2004
    Applicant: CELL THERAPEUTICS, INC.
    Inventors: David Porubek, Anil M. Kumar, Charles R. Bredl, J. Peter Klein
  • Pyrimidines and uses thereof
    Publication number: 20040204386
    Abstract: The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity and/or proliferation of cells such as tumor-cells.
    Type: Application
    Filed: September 24, 2003
    Publication date: October 14, 2004
    Applicant: Cell Therapeutics, Inc.
    Inventors: Rama Bhatt, Baoqing Gong, Feng Hong, Scott A. Jenkins, J. Peter Klein, Cory T. Kohm, John Tulinsky
  • Pyridines and uses thereof
    Publication number: 20040198728
    Abstract: The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity and/or proliferation of cells such as tumor cells.
    Type: Application
    Filed: September 22, 2003
    Publication date: October 7, 2004
    Applicant: Cell Therapeutics, Inc.
    Inventors: Feng Hong, J. Peter Klein