Abstract: The present invention concerns the combination of dehydroepiandrosterone (DHEA) and at least one aromatase inhibitor and the use of such a combination to produce a medicament for treating relative and/or absolute androgen deficiency in men. Selective aromatase inhibitors such as atamestan, formestan, pentrozol, aramidex, fadrozol, CGS 20267 and/or vorozol, are preferred for producing the medicament according to the invention.

Abstract: Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is changed, by administering preferably transdermally the estrogen and the progestogen contained in separate extrudable pharmaceutical compositions from a dispenser which contains means, preferably adjustable only by the attending physician or dispensing pharmacist, for varying the volume of either or both of the respective compositions which is dispensed as a single dose from the dispenser in response to a defined digital dispensing manipulation of the dispenser thereby facilitating optimal compliance to a combination of HRT with individually adjusted dosages of the estrogen and progestogen.

Abstract: The invention relates to pharmaceutical combination preparations that comprise aromatase inhibitors and substances with estrogenic action as well as their use for a selective estrogen replacement therapy (SERT), especially in the case of menopausal symptoms and the manifestations accompanying them. As substances with estrogenic action, estrogens, optionally also in combination with gestagens, are preferably used. The combination preparations according to the invention are preferably used in the case of menopausal symptoms, especially for treatment and prevention of postmenopausal osteoporosis and breast cancer as well as in other long-term sequelae that can be caused by estrogen deficiency.