Patents by Inventor J. Richard Gyory
J. Richard Gyory has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8368285Abstract: Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.Type: GrantFiled: December 16, 2011Date of Patent: February 5, 2013Assignees: Massachusette Institute of Technology, SpringLeaf TherapeuticsInventors: Yet-Ming Chiang, Timothy E. Chin, Michael J. Cima, J. Richard Gyory
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Patent number: 8337457Abstract: In one embodiment, an apparatus comprises a reservoir for containing a fluid, a first actuator, a transfer structure, and a second actuator. The first actuator is configured to exert a first force on the reservoir when moved from a first configuration to a second configuration such that a first volume of fluid within the reservoir is communicated out of the reservoir. The transfer structure is disposed between the first actuator and the reservoir and has a surface configured to engage the reservoir such that the first force exerted by the first actuator is distributed across a surface of the reservoir engaged by the transfer structure. The second actuator is configured to exert a second force on the reservoir when the second actuator is moved from a first configuration to a second configuration such that a second volume of fluid within the reservoir is communicated out of the fluid reservoir.Type: GrantFiled: May 5, 2011Date of Patent: December 25, 2012Assignee: SpringLeaf Therapeutics, Inc.Inventors: Glenn R. Booma, Alessandro Pizzochero, J. Richard Gyory
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Patent number: 8224435Abstract: This invention relates to an electrotransport device, which incorporates a flexible conductive element within the reservoir housing of the device, which permits electrical communication from within the housing to outside of the housing without the use of opening, which require various methods of sealing the opening against leaks and moisture.Type: GrantFiled: March 30, 2004Date of Patent: July 17, 2012Assignee: Alza CorporationInventor: J. Richard Gyory
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Publication number: 20120175998Abstract: Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.Type: ApplicationFiled: December 16, 2011Publication date: July 12, 2012Applicants: SpringLeaf Therapeutics, Massachusetts Institute of TechnologyInventors: Yet-Ming Chiang, Timothy E. Chin, Michael J. Cima, J. Richard Gyory
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Publication number: 20110275996Abstract: Devices and methods for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir containing a fluid and a fluid communicator in fluid communication with the reservoir. An actuator is coupled to the reservoir and configured to displace and exert a force on the reservoir for a time period upon actuation such that fluid within the reservoir is communicated through the fluid communicator. An amplification mechanism is coupled to the actuator. The amplification mechanism is configured to increase at least one of the force, the displacement, or the time period the force is exerted by the actuator on the reservoir. In some embodiments, a transfer structure is disposed between the amplification mechanism and the reservoir. The transfer structure is configured to contact the reservoir upon actuation of the actuator. In some embodiments, the actuator can be an electrochemical actuator.Type: ApplicationFiled: May 6, 2011Publication date: November 10, 2011Applicant: SPRINGLEAF THERAPEUTICS, INC.Inventors: J. Richard Gyory, Alessandro Pizzochero
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Publication number: 20110275995Abstract: Devices and methods for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir configured to contain a fluid, a first actuator coupled to the reservoir, a second actuator coupled to the first actuator, and an adaptor at least partially disposed between the first actuator and the second actuator. The first actuator and the second actuator are configured to collectively exert a force on the reservoir such that at least a portion of the fluid within the reservoir is communicated out of the reservoir. The adaptor is configured to couple the first actuator and the second actuator.Type: ApplicationFiled: May 5, 2011Publication date: November 10, 2011Applicant: SPRINGLEAF THERAPEUTICS, INC.Inventors: J. Richard Gyory, Alessandro Pizzochero
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Publication number: 20110275997Abstract: Devices, methods, and kits for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, an apparatus comprises a reservoir for containing a fluid, a first actuator, a transfer structure, and a second actuator. The first actuator has a first configuration and a second configuration and is configured to exert a first force on the reservoir when moved from its first configuration to its second configuration such that a first volume of fluid within the reservoir is communicated out of the fluid reservoir. The transfer structure is disposed between the first actuator and the reservoir and has a surface configured to engage the reservoir such that the first force exerted by the first actuator is distributed across a surface of the reservoir engaged by the transfer structure.Type: ApplicationFiled: May 5, 2011Publication date: November 10, 2011Applicant: SPRINGLEAF THERAPEUTICS, INC.Inventors: Glenn R. Booma, Alessandro Pizzochero, J. Richard Gyory
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Publication number: 20110275998Abstract: Devices and methods for delivering a fluid to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir for containing a fluid and a fluid communicator in fluid communication with the reservoir. An electrochemical actuator is coupled to the reservoir and configured to exert a force on the reservoir upon actuation such that fluid within the reservoir is communicated through the fluid communicator. The actuator includes a first end that is constrained and a second end that is not constrained. The actuator is configured to bend at a location along a length of the actuator when actuated such that the second end of the actuator is displaced in a direction toward the fluid reservoir. The actuator can be an electrochemical actuator. The apparatus can further include a transfer structure disposed between the actuator and the reservoir configured to contact the reservoir upon actuation of the actuator.Type: ApplicationFiled: May 6, 2011Publication date: November 10, 2011Applicant: SPRINGLEAF THERAPEUTICS, INC.Inventors: J. Richard Gyory, Daniel Hamilton, Alessandro Pizzochero, Jon Taylor
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Publication number: 20110098676Abstract: A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The electrochemical actuator is operative to cause fluid to be delivered from the fluid source into the fluid communicator.Type: ApplicationFiled: October 27, 2010Publication date: April 28, 2011Inventors: Yet-Ming Chiang, Michael J. Cima, J. Richard Gyory, Glenn R. Booma
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Patent number: 7844326Abstract: This invention relates to an electrotransport device, which incorporates a conductive element within the reservoir housing of the device, which permits electrical communication from within the housing to outside of the housing without the use of opening, which require various methods of sealing the openings against leaks and moisture.Type: GrantFiled: December 20, 2002Date of Patent: November 30, 2010Assignee: Alza CorporationInventors: Wanda Faye Dent, J. Richard Gyory, Michael Joseph Grace
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Patent number: 7828771Abstract: A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The electrochemical actuator is operative to cause fluid to be delivered from the fluid source into the fluid communicator.Type: GrantFiled: July 28, 2008Date of Patent: November 9, 2010Assignee: Entra Pharmaceuticals, Inc.Inventors: Yet-Ming Chiang, Michael J. Cima, J. Richard Gyory, Glenn R. Booma
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Patent number: 7763455Abstract: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.Type: GrantFiled: May 13, 2004Date of Patent: July 27, 2010Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael Cima, Wendy Pryce-Lewis, Javier Gonzalez-Zugasti, J. Richard Gyory, Anthony Lemmo, Julie Monagle
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Publication number: 20090028824Abstract: A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The electrochemical actuator is operative to cause fluid to be delivered from the fluid source into the fluid communicator.Type: ApplicationFiled: July 28, 2008Publication date: January 29, 2009Applicant: ENTRA PHARMACEUTICALS, INC.Inventors: Yet-Ming Chiang, Michael J. Cima, J. Richard Gyory, Glenn R. Booma
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Patent number: 7449342Abstract: The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.Type: GrantFiled: November 3, 2003Date of Patent: November 11, 2008Assignee: Transform Pharmaceuticals, Inc.Inventors: Nathan Kane, Michael Cima, Javier Gonzalez-Zugasti, Jeanie Cherng, Anthony Lemmo, J. Richard Gyory
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Patent number: 7449307Abstract: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.Type: GrantFiled: October 27, 2003Date of Patent: November 11, 2008Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael Cima, Wendy Pryce Lewis, Javier Gonzalez-Zugasti, J. Richard Gyory, Anthony V. Lemmo, Julie Monagle
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Publication number: 20080253935Abstract: The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.Type: ApplicationFiled: June 20, 2008Publication date: October 16, 2008Inventors: Nathan Kane, Michael Cima, Javier Gonzalez-Zugasti, Jeanie Cherng, Anthony Lemmo, J. Richard Gyory, Wendy Pryce-Lewis, Hongming Chen
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Patent number: 7172859Abstract: The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.Type: GrantFiled: February 20, 2003Date of Patent: February 6, 2007Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael J. Cima, Hongming Chen, J. Richard Gyory
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Patent number: 7087035Abstract: A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.Type: GrantFiled: December 8, 2000Date of Patent: August 8, 2006Assignee: Alza CorporationInventors: Joseph C. Trautman, Michel J. N. Cormier, Kellee Eng, Wei-Qi Lin, Hyunok L. Kim, Sara L. Sendelbeck, Armand P. Neukermans, Bruce P. Edwards, Wai-Loong Lim, Andrew I. Poutiatine, J. Richard Gyory
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Patent number: 6908760Abstract: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in-situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.Type: GrantFiled: May 16, 2003Date of Patent: June 21, 2005Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael Cima, Wendy Pryce Lewis, Javier Gonzalez-Zugasti, J Richard Gyory, Anthony V. Lemmo, Julie Monagle
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Patent number: 6852526Abstract: The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a surface of the second member. Each sample surface is substantially the same size as each opening. The transdermal assay apparatus also includes a magnetic clamp configured to clamp a tissue specimen between the sample surface and the opening. The magnetic clamp preferably includes a magnet having a strength that is selected based on the clamping force required between the first member and the second member. The invention also provides a method for using a transdermal assay apparatus.Type: GrantFiled: October 28, 2002Date of Patent: February 8, 2005Assignee: Transform Pharmaceuticals, Inc.Inventors: Michael J. Cima, Hongming Chen, J. Richard Gyory