Abstract: Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions.

Abstract: Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions.

Abstract: A system and method for characterizing tissues of a subject using multi-parametric imaging are provided. In some aspects, the method includes receiving a set of multi-parametric magnetic resonance (“MR”) images acquired from a subject using an MR imaging system, and selecting at least one region of interest (“ROI”) in the subject using one or more images in the set of multi-parametric MR images. The method also includes performing a texture analysis on corresponding ROIs in the set of multi-parametric MR images to generate a set of texture features, and applying a classification scheme, using the set of texture features, to characterize tissues in the ROI. The method further includes generating a report indicative of characterized tissues in the ROI.

Abstract: Methods that implement image-guided tissue analysis, MRI-based computational modeling, and imaging informatics to analyze the diversity and dynamics of molecularly-distinct subpopulations and the evolving competitive landscapes in human glioblastoma multiforme (“GBM”) are provided. Machine learning models are constructed based on multiparametric MRI data and molecular data (e.g., CNV, exome, gene expression). Models can also be built based on specific biological factors, such as sex and age. Inputting MRI data into the trained predictive models generates maps that depict spatial patterns of molecular markers, which can be used to quantify and co-localize regions molecularly distinct subpopulations in tumors and other regions, such as the non-enhancing parenchyma, or brain around tumor (“BAT”) regions.

Abstract: A system and method for characterizing tissues of a subject using multi-parametric imaging are provided. In some aspects, the method includes receiving a set of multi-parametric magnetic resonance (“MR”) images acquired from a subject using an MR imaging system, and selecting at least one region of interest (“ROI”) in the subject using one or more images in the set of multi-parametric MR images. The method also includes performing a texture analysis on corresponding ROIs in the set of multi-parametric MR images to generate a set of texture features, and applying a classification scheme, using the set of texture features, to characterize tissues in the ROI. The method further includes generating a report indicative of characterized tissues in the ROI.

Abstract: The present invention relates to a method for filtering time-varying MR signal data prior to image reconstruction. A one-dimensional FT is applied to the time-varying MR signal data along each frequency-encode line of k space. The phase p of each complex pair (R,I) of the FT transformed data is calculated to create a phase profile for each frequency-encode line. This process is repeated for all time points of the time-varying MR signal data. The time course of each point within the phase profile is then transformed into Stockwell domain producing ST spectra. Frequency component magnitudes indicative of an artifact are determined and replaced with a predetermined frequency component magnitude. Each of the ST spectra is then collapsed into a one-dimensional function. New real and imaginary values (R?,I?) of the complex Fourier data are calculated based on the collapsed ST spectra which are transformed using one-dimensional inverse Fourier transformation for producing filtered time-varying MR signal data.

Abstract: The present invention relates to a method for visualizing ST data based on principal component analysis. ST data indicative of a plurality of local S spectra, each local S spectrum corresponding to an image point of an image of an object are received. In a first step principal component axes of each local S spectrum are determined. This step is followed by the determination of a collapsed local S spectrum by projecting a magnitude of the local S spectrum onto at least one of its principal component axes, thus reducing the dimensionality of the S spectrum. After determining a weight function capable of distinguishing frequency components within a frequency band a texture map for display is generated by calculating a scalar value from each principal component of the collapsed S spectrum using the weight function and assigning the scalar value to a corresponding position with respect to the image.

Abstract: The present invention relates to a method and system for distributed computing an S transform dataset of multidimensional image data of an object. The multidimensional image data are fast Fourier transformed into Fourier domain producing a Fourier spectrum. The respective Fourier frequencies are then partitioned into a plurality of portions of frequencies for simultaneously processing. Processing of each of the plurality of portions of the Fourier frequencies is assigned to a respective processor of a plurality of processors. The Fourier spectrum of multidimensional image data and each of the plurality of portions of the Fourier frequencies is transmitted to the respective processor. The portions of the Fourier frequencies are then simultaneously processed in order to produce the S transform dataset. The S transform data are then collected and stored.

Abstract: The present invention relates to a method for filtering time-varying MR signal data prior to image reconstruction. A one-dimensional FT is applied to the time-varying MR signal data along each frequency-encode line of k space. The phase p of each complex pair (R, I) of the FT transformed data is calculated to create a phase profile for each frequency-encode line. This process is repeated for all time points of the time-varying MR signal data. The time course of each point within the phase profile is then transformed into Stockwell domain producing ST spectra. Frequency component magnitudes indicative of an artifact are determined and replaced with a predetermined frequency component magnitude. Each of the ST spectra is then collapsed into a one-dimensional function. New real and imaginary values (R?, I?) of the complex Fourier data are calculated based on the collapsed ST spectra which are transformed using one-dimensional inverse Fourier transformation for producing filtered time-varying MR signal data.

Abstract: The present invention relates to a method and system for enhancing resolution of a magnetic resonance image of an object. The method combines information from a plurality of low-resolution images with a Field Of View shifted by a distance less than a pixel width to create a synthesized image having substantially improved image quality. Information from the low-resolution images is merged and application of an aperture function enhances the SNR of the synthesized image resulting in synthesized images having a substantially higher spatial resolution as well as a substantially increased SNR. The method and system for enhancing resolution of a magnetic resonance image is highly beneficial for a MRI practitioner by substantially improving image quality, thus facilitating diagnostic methods such as texture analysis and disease specific tissue segmentation.

Abstract: The present invention relates to a method for processing magnetic resonance signal data. magnetic resonance signal data in dependence upon a magnetic resonance signal time series are received. The magnetic resonance signal data are then transformed into a time-frequency Stockwell domain using a localizing time window having a frequency dependent window width in order to provide multi-resolution in the time-frequency domain. The Stockwell transformed magnetic resonance signal data are then processed in the Stockwell domain, for example, filtered based on time-frequency information of the Stockwell transformed magnetic resonance signal data. The processed Stockwell transformed magnetic resonance signal data are then transformed into Fourier domain by summing the Stockwell transformed magnetic resonance signal data over time indices of the Stockwell domain. In a further step the Fourier transformed magnetic resonance signal data are then transformed into time domain using inverse Fourier transformation.

Abstract: The present invention relates to a method and system for enhancing resolution of a magnetic resonance image of an object. The method combines information from a plurality of low-resolution images with a Field Of View shifted by a distance less than a pixel width to create a synthesized image having substantially improved image quality. Information from the low-resolution images is merged and application of an aperture function enhances the SNR of the synthesized image resulting in synthesized images having a substantially higher spatial resolution as well as a substantially increased SNR. The method and system for enhancing resolution of a magnetic resonance image is highly beneficial for a MRI practitioner by substantially improving image quality, thus facilitating diagnostic methods such as texture analysis and disease specific tissue segmentation.

Abstract: The present invention relates to a method and system for distributed computing an S transform dataset of multidimensional image data of an object. The multidimensional image data are fast Fourier transformed into Fourier domain producing a Fourier spectrum. The respective Fourier frequencies are then partitioned into a plurality of portions of frequencies for simultaneously processing. Processing of each of the plurality of portions of the Fourier frequencies is assigned to a respective processor of a plurality of processors. The Fourier spectrum of multidimensional image data and each of the plurality of portions of the Fourier frequencies is transmitted to the respective processor. The portions of the Fourier frequencies are then simultaneously processed in order to produce the S transform dataset. The S transform data are then collected and stored.

Abstract: The present invention relates to a method for visualizing ST data based on principal component analysis. ST data indicative of a plurality of local S spectra, each local S spectrum corresponding to an image point of an image of an object are received. In a first step principal component axes of each local S spectrum are determined. This step is followed by the determination of a collapsed local S spectrum by projecting a magnitude of the local S spectrum onto at least one of its principal component axes, thus reducing the dimensionality of the S spectrum. After determining a weight function capable of distinguishing frequency components within a frequency band a texture map for display is generated by calculating a scalar value from each principal component of the collapsed S spectrum using the weight function and assigning the scalar value to a corresponding position with respect to the image.

Abstract: The present invention relates to a method for processing magnetic resonance signal data. magnetic resonance signal data in dependence upon a magnetic resonance signal time series are received. The magnetic resonance signal data are then transformed into a time-frequency Stockwell domain using a localizing time window having a frequency dependent window width in order to provide multi-resolution in the time-frequency domain. The Stockwell transformed magnetic resonance signal data are then processed in the Stockwell domain, for example, filtered based on time-frequency information of the Stockwell transformed magnetic resonance signal data. The processed Stockwell transformed magnetic resonance signal data are then transformed into Fourier domain by summing the Stockwell transformed magnetic resonance signal data over time indices of the Stockwell domain. In a further step the Fourier transformed magnetic resonance signal data are then transformed into time domain using inverse Fourier transformation.

Abstract: The present invention relates to a method for filtering time-varying MR signal data prior to image reconstruction. A one-dimensional FT is applied to the time-varying MR signal data along each frequency-encode line of k space. The phase p of each complex pair (R, I) of the FT transformed data is calculated to create a phase profile for each frequency-encode line. This process is repeated for all time points of the time-varying MR signal data. The time course of each point within the phase profile is then transformed into Stockwell domain producing ST spectra. Frequency component magnitudes indicative of an artifact are determined and replaced with a predetermined frequency component magnitude. Each of the ST spectra is then collapsed into a one-dimensional function.