Patents by Inventor Jacek Michal Zielonka

Jacek Michal Zielonka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mito-honokiol compounds and methods of synthesis and use thereof
    Patent number: 11897910
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 13, 2024
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • Mito-magnolol compounds and methods of synthesis and use thereof
    Patent number: 11612610
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 28, 2023
    Assignees: Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Mito-Magnolol Compounds and Methods of Synthesis and Use Thereof
    Publication number: 20220211727
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Application
    Filed: August 9, 2021
    Publication date: July 7, 2022
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Modified mito-metformin compounds and methods of synthesis and use thereof
    Patent number: 11274114
    Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: March 15, 2022
    Assignees: The Medical College of Wisconsin, Inc., AIX-Marseille Universite, Iowa State University Research Foundation, Inc.
    Inventors: Balaraman Kalyanaramn, Micael J. Hardy, Marcos Lopez, Olivier Ouari, Jacek Michal Zielonka
  • Targeting Redox-Active Pyridinium Cations to Mitochondria to Inhibit Proliferation of Drug-Resistant Cancer Cells
    Publication number: 20210395280
    Abstract: The present invention provides novel mito-pyridinium compounds, prodrugs and the uses thereof for the treatment of cancer, particularly drug resistant cancer.
    Type: Application
    Filed: November 1, 2019
    Publication date: December 23, 2021
    Inventors: Jacek Michal Zielonka, Adam Bartlomiej Sikora, Balaraman Kalyanaraman
  • Mito-magnolol compounds and methods of synthesis and use thereof
    Patent number: 11083739
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: August 10, 2021
    Assignees: THE MEDICAL COLLEGE OF WISCONSIN, INC., AIX-MARSEILLE UNIVERSITE
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • Mito-Honokiol Compounds and Methods of Synthesis and Use Thereof
    Publication number: 20210070787
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 11, 2021
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • Mito-honokiol compounds and methods of synthesis and use thereof
    Patent number: 10836782
    Abstract: The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment of cancer.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 17, 2020
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Micael J. Hardy, Oliver Ouari, Ming You
  • MITO-MAGNOLOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20200222433
    Abstract: The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.
    Type: Application
    Filed: December 13, 2019
    Publication date: July 16, 2020
    Applicants: THE MEDICAL COLLEGE OF WISCONSIN, INC., AIX-MARSEILLE UNIVERSITE
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael Joël Hardy, Olivier Ouari
  • MODIFIED MITO-METFORMIN COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20170275313
    Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
    Type: Application
    Filed: August 13, 2015
    Publication date: September 28, 2017
    Inventors: Balaraman Kalyanaramn, Micael J. Hardy, Marcos Lopez, Olivier Ouari, Jacek Michal Zielonka